Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury

Ye, Feng; Yang, Qinghua; Xu, Jiancheng; Qian, Guisheng; Liu, You-Sheng

doi:10.1016/j.yexmp.2008.09.002

Cited by 22 publications

(19 citation statements)

References 36 publications

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“…Additionally, we found that HMGB-1 was negatively correlated with serum albumin levels and was positively related with TG, TC, LDL, and 24-h urinary proteins (Table 3), suggesting a positive relationship between HMGB-1 expression and renal dysfunction. This is consistent with the results of previous studies, which reported that acute renal injuries significantly elevated HMGB-1 levels, but these levels can be improved by anti-inflammation treatment with glutamine (Feng et al, 2008). Thus, the HMGB-1 induced inflammatory response may be an important mechanism underlying the pathogenesis and progression of PNS.…”

Section: Discussionsupporting

confidence: 92%

Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance

Wang¹,

Qu²,

Xi³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the expression levels of high-mobility group box protein 1 (HMGB-1), CXC chemokine ligand 16 (CXCL16), microRNA (miRNA)-30a and transforming growth factor b1 (TGF-b1) in primary nephritic syndrome (PNS) patients and the clinical significance of this expression. A total of 56 patients with PNS were included in the PNS group, while 50 healthy subjects formed the normal control group. Serum levels of HMGB-1, CXCL16, miRNA-30a, and urinary TGF-b1 concentrations were quantified along with other biochemical indices, including serum albumin, triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein (LDL), high-density lipoprotein, and urinary proteins. The correlation between levels of HMGB-1, CXCL16, miRNA-30a, and TGF-b1 and biochemical indexes was further analyzed. PNS group patients had significantly higher levels of HMGB-1, CXCL16, miRNA30a, and TGF-b1 compared to the control group (P < 0.05). PNS patients also had higher 24-h urinary protein, TG, TC, and LDL levels but lower serum albumin compared to subjects in the control group (P < 0.05). Serum HMGB-1, CXCL16, miRNA-30a, and urinary TGF-b1 levels were all negatively correlated with serum albumin levels, but were positively correlated with TG, TC, LDL, and 24-h urinary protein (P < 0.05 in all cases). Additionally, a positive correlation existed among serum HMGB-1, CXCL16, miRNA-30a, and urinary TGF-b1 levels (P < 0.01). HMGB-1, CXCL16, miRNA-30a, and urinary TGF-b1 were highly expressed in PNS patients and may play important roles in the pathogenesis and development of PNS.

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Section: Discussionsupporting

confidence: 92%

Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance

Wang¹,

Qu²,

Xi³

et al. 2015

Genet. Mol. Res.

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show abstract

“…The cell pellet was resuspended, and viable cells were counted using trypan blue dye exclusion. The sediment was used for counting neutrophil numbers after Giemsa staining according to the method described by Feng et al (2008).…”

Section: Balf Analysismentioning

confidence: 99%

Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats

Zhang

Zhou

Dai

et al. 2015

Experimental and Molecular Pathology

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“…Annexin V-positive cells were considered viable apoptotic cells (early apoptotic cells), propidium iodine (PI)-positive cells were defined as necrotic cells, and Annexin V and PI double positive cells were defined as non-viable apoptotic cells (late apoptotic cells). Because PMNs were absent from the BALF of the control group, we replaced BALF with peripheral blood in the analysis of the control group according to Feng et al [16] .…”

Section: Pmn Apoptosis By Ao/eb Staining and Fcmmentioning

confidence: 99%

“…Preparation of rat lymphocyte separating medium The separating medium was prepared according to the method described by Feng et al [16] . Solution A (9% Ficoll solution): 3.4 parts normal saline was added to 1 part 40% Ficoll and mixed thoroughly.…”

Section: Pmn Apoptosis By Ao/eb Staining and Fcmmentioning

confidence: 99%

“…The delay in apoptosis may lead to the prolonged release of PMN products and direct tissue injury, which then participate in the development of ALI [15] . Therefore, the inhibition of PMN apoptosis leads to inflammation and lung tissue damage, whereas the enhancement of PMN apoptosis may reduce lung inflammation and damage [16] . We speculated that the enhancement of PMN apoptosis might be responsible for the inhibition of PMN infiltration in the lung, thereby mediating the protective effect of SO 2 .…”

Section: Introductionmentioning

confidence: 99%

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Sulfur dioxide attenuates LPS-induced acute lung injury via enhancing polymorphonuclear neutrophil apoptosis

Huang

Liu

et al. 2012

Acta Pharmacol Sin

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Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury

Cited by 22 publications

References 36 publications

Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance

Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance

Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats

Sulfur dioxide attenuates LPS-induced acute lung injury via enhancing polymorphonuclear neutrophil apoptosis

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