Effects of<i>Bifidobacterium animalis</i>administered during lactation on allergic and autoimmune responses in rodents

Ezendam, Janine; Klerk, Arja de; Gremmer, Eric R.; Loveren, Henk Van

doi:10.1111/j.1365-2249.2008.03788.x

Cited by 106 publications

(71 citation statements)

References 34 publications

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“…9 Bifidobacterium Actinobacteria Increased Bifidobacterium associated with IBD, 32 but administration of some Bifidobacterium spp. and other probiotic bacteria associated with EAE amelioration; 33,34 how increased Bifidobacterium identified in some studies of the gut microbiome in MS relates to disease activity is unclear.…”

Section: Akkermansia Verrucomicrobiamentioning

confidence: 99%

Breaking down the gut microbiome composition in multiple sclerosis

et al. 2016

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Background:The gut microbiome, which consists of a highly diverse ecologic community of microorganisms, has increasingly been studied regarding its role in multiple sclerosis (MS) immunopathogenesis. This review critically examines the literature investigating the gut microbiome in MS. Methods: A comprehensive search was performed of PubMed databases and ECTRIMS meeting abstracts for literature relating to the gut microbiome in MS. Controlled studies examining the gut microbiome in patients with MS were included for review. Results: Identified studies were predominantly case-control in their design and consistently found differences in the gut microbiome of MS patients compared to controls. We examine plausible mechanistic links between these differences and MS immunopathogenesis, and discuss the therapeutic implications of these findings. Conclusions: Review of the available literature reveals potential immunopathogenic links between the gut microbiome and MS, identifies avenues for therapeutic advancement, and emphasizes the need for further systematic study in this emerging field.

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Section: Akkermansia Verrucomicrobiamentioning

confidence: 99%

Breaking down the gut microbiome composition in multiple sclerosis

et al. 2016

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“…Segmented filamentous bacteria have been positively correlated with EAE (29). In contrast, B. fragilis, Bifidobacterium sp., and some strains of Lactobacillus negatively correlate with EAE (69)(70)(71)(72). Evidence is now also emerging for a role by commensal microbiota in the etiology of human MS. Faecalibacterium (phylum Firmicutes) has been found in low abundance in untreated MS patients, and this was reversed by glatimer acetate (GA) treatment (73).…”

Section: Gut Microbiota In Tnfr2mentioning

confidence: 99%

TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease

Miller

Bonn

Franklin

et al. 2015

The Journal of Immunology

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TNF-α antagonists provide benefit to patients with inflammatory autoimmune disorders such as Crohn’s disease, rheumatoid arthritis, and ankylosing spondylitis. However, TNF antagonism unexplainably exacerbates CNS autoimmunity, including multiple sclerosis and neuromyelitis optica. The underlying mechanisms remain enigmatic. We demonstrate that TNFR2 deficiency results in female-biased spontaneous autoimmune CNS demyelination in myelin oligodendrocyte glycoprotein–specific 2D2 TCR transgenic mice. Disease in TNFR2−/− 2D2 mice was associated with CNS infiltration of T and B cells as well as increased production of myelin oligodendrocyte glycoprotein–specific IL-17, IFN-γ, and IgG2b. Attenuated disease in TNF−/− 2D2 mice relative to TNFR2−/− 2D2 mice identified distinctive roles for TNFR1 and TNFR2. Oral antibiotic treatment eliminated spontaneous autoimmunity in TNFR2−/− 2D2 mice to suggest role for gut microbiota. Illumina sequencing of fecal 16S rRNA identified a distinct microbiota profile in male TNFR2−/− 2D2 that was associated with disease protection. Akkermansia muciniphila, Sutterella sp., Oscillospira sp., Bacteroides acidifaciens, and Anaeroplasma sp. were selectively more abundant in male TNFR2−/− 2D2 mice. In contrast, Bacteroides sp., Bacteroides uniformis, and Parabacteroides sp. were more abundant in affected female TNFR2−/− 2D2 mice, suggesting a role in disease causation. Overall, TNFR2 blockade appears to disrupt commensal bacteria–host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice. Under this paradigm, microbes likely contribute to an individual’s response to anti-TNF therapy. This model provides a foundation for host immune–microbiota-directed measures for the prevention and treatment of CNS-demyelinating autoimmune disorders.

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“…Furthermore, treatment with oral antibiotics also reduce significantly the severity of EAE (30,31). The experimental evidence gathered using animal model studies indicate the effects of the microbiota in the regulation of EAE in animals (24,(26)(27)(28)(32)(33)(34)(35)(36). Furthermore, gut microbes, such as B. fragilis and Lactobacillus rhamnosus have been shown to interact with neurons in the enteric nervous system (ENS) directly and affect their function (37).…”

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confidence: 99%

The chicken or the egg dilemma: intestinal dysbiosis in multiple sclerosis

2017

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Comment on: Jangi S, Gandhi R, Cox LM, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun 2016;7:12015.Abstract: Recent findings suggest that the intestinal microbiota of patients suffering from relapsing remitting multiple sclerosis (MS) shows changes on the relative abundances of archaeal and bacterial genera. Although the richness and overall structure of the microbiota may be similar compared to the intestinal microbiota of healthy controls, elevated and reduced frequencies suggest a dysbiotic microbiota in MS. Over the past decade experimental evidence obtained in murine models of the disease highlighted the important relevance of the microbiota in the regulation of the immune system and in the severity of the disease. More recent findings on peripheral immune cells derived from human MS patients support the initial observations that changes in the microbiota may affect immunological pathways that could exacerbate disease. However, important questions remain to be answered. For instance, it is unclear whether dysbiosis precedes disease or, if in the contrary, an autoimmune disease such as MS can lead to gut dysbiosis. In this brief discussion, we speculate about this later possibility based on findings observed in murine models of disease. Further human studies are needed to answer the dilemma and determine specific immunomodulatory pathways that could have an impact on the therapeutic approaches to treat MS.

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Effects ofBifidobacterium animalisadministered during lactation on allergic and autoimmune responses in rodents

Cited by 106 publications

References 34 publications

Breaking down the gut microbiome composition in multiple sclerosis

Breaking down the gut microbiome composition in multiple sclerosis

TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease

The chicken or the egg dilemma: intestinal dysbiosis in multiple sclerosis

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