Effects of <i>DGAT1</i> and <i>GHR</i> on milk yield and milk composition in the Chinese dairy population

Sun, Dongxiao; Jia, Jingdun; Ma, Yuan; Zhang, Y.; Wang, Y.; Yu, Ying

doi:10.1111/j.1365-2052.2009.01945.x

Cited by 42 publications

(32 citation statements)

References 11 publications

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“…This result is consistent with those of previous studies of different breeds, including UK Holsteins (Banos et al, 2008), German Holsteins (Kaupe et al, 2004), Polish Holsteins (Nowacka-Woszuk et al, 2008), and Chinese Holsteins (Sun et al, 2009).…”

Section: Alleles Genotypes and Composite Genotype Frequencysupporting

confidence: 93%

“…However, the GH gene showed no significant effect on any and was not included in the analysis. According to previous studies (Ikonen et al, 2001;Boettcher et al, 2004;Comin et al, 2008;Sun et al, 2009), inconsistent effects, both positive and negative, have been detected depending on the breed or line of dairy cattle. If the studies were conducted using different breeds or lines of dairy cattle, different genetic structures and epistasis effects may have been observed.…”

Section: Effects Of a Single Gene On Milk Production And Milk Composimentioning

confidence: 99%

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Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

2015

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ABSTRACT. The objectives of this study were to determine the effects of a single gene and composite genotype of the casein gene family, including the beta-lactoglobulin gene (beta-LGB), acyl-CoA: diacylglycerol acyltransferase 1 gene (DGAT1), growth hormone gene (GH), and luteinizing hormone receptor gene (LHR) on milk yield, milk composition, the percentage of fat, protein, solids-not-fat, and total solid in crossbred Holsteins. A total of 231 crossbred Holstein cows were examined for the study. The genotype of the beta-casein gene was analyzed by allele-specific polymerase chain reaction, while the alpha-S1, alpha-S2, kappa-casein, DGAT1, beta-LGB, and GH genes were analyzed using a polymerase chain reaction-restriction fragment length polymorphism assay. The association between genes and milk yield and milk composition was analyzed. Three pairs of genes, for which significant associations were detected, were beta + kappacasein, DGAT1 + beta-casein, and GH + beta-LGB. In the single-gene model, most loci are significantly associated with traits. A significant 2561-2571 (2015) association between the composite genotype and the traits was detected in all composite genotypes. GH + beta-LGB appears to be the most suitable variants for improving milk production and percentage of milk protein. Overall, the effects of the composite genotype and single gene were different. A physical or functional relationship between genes is necessary for investigating gene markers.

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Section: Alleles Genotypes and Composite Genotype Frequencysupporting

confidence: 93%

Section: Effects Of a Single Gene On Milk Production And Milk Composimentioning

confidence: 99%

Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

2015

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“…According to the results, milk fat in the milk from the cattle with high allele frequency is meaningfully higher than the milk from the cattle with the low allele frequency. Sun et al [13] have pointed out that the "K" allele of the DGAT1 gene increases the fat concentration of the milk but reduces the milk productivity. However, our findings in milk productivity parameter are not in parallel with Sun et al's findings.…”

Section: Discussionmentioning

confidence: 99%

Comparision of DGAT1 K232A Polymorphism and its Effects on some Milk Quality Parameters in Holstein and Native Black Race Cattles

Cerit¹,

Dümen²,

Sezgin³

2014

Kafkas Univ Vet Fak Derg

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SummaryIn this study, effects of DGAT1 K232 polymorphism and the allele frequency differences of "K" (alanine variant) and "L" (lysine variant) on some cattle milk qualities and some microbiological parameters which pose a risk on consumer health were investigated. For this purpose, 2 years old 50 cattles were used as material (25 Holstein race and 25 Native Black race). Blood samples were collected for determining the allele frequencies of DGAT1 gene. Then, during the experimental period (1 month) the milk of the cattles were collected once a week and the milk samples has been explored for some important foodborne pathogens (Total Aerobic Bacteria, Coliforms, Escherichia coli, Listeria monocytogenes and Staphylococcus aureus) and milk quality parameters (pH, fat, density and acidity). According to the findings, it has been identified that DGAT1 gene frequency differences were significantly effective on some the parameters of milk qualities and the growth of coliforms, Esherichia coli and Staphylococcus aureus. Keywords: DGAT1 gene, Milk quality, Polymorphism, Cattle, Foodborne pathogens Holstein ve Yerli Kara Sığır Irklarında DGAT1 K232a Poliformizminin ve Bunların Bazı Süt Kalite Parametrelerine Etkisinin Araştırılması ÖzetBu çalışmada, farklı ırk sığırlarda DGAT1 K232 polimorfizmi araştırılmış ve DGAT1 geninde bulunan "K" (alanin varyantı) ve "L" (lizin vasryantı) allel frekans farklılıklarının sığırların bazı süt kalite (süt verimi, sütte yağ oranı, pH vb.) parametrelerine ve tüketici sağlığı açısından risk teşkil eden önemli bazı gıda kaynaklı patojenlere etkisi incelenmiştir. Bu amaçla 2 yaşlı, 50 adet sığır (25 adet Holstein ırkı, 25 adet ise Yerlikara ırkı) materyal olarak kullanılmıştır. Sığırlardan kan örnekleri alınarak DGAT1 geni allel frekansları belirlenmiş ve daha sonraki dönemde ise haftada 1 kez olmak üzere 1 ay boyunca aynı sığırlardan süt örnekleri toplanmış ve toplanan süt örnekleri bazı önemli gıda kaynaklı mikrobiyolojik parametreler (toplam mezofilik erobik bakteri, koliformlar, Escherichia coli, Listeria monocytogenes ve Staphylococcus aureus olmak üzere) ve süt kalite parametreleri (pH, süt yağı, sütün yoğunluğu ve sütün asiditesi olmak üzere) açısından incelenmiştir. Elde edilen bulgulara göre DGAT1 geni allel frekans farklılıklarının, tüm süt kalite parametreleri ve mikrobiyolojik parametrelerden koliformlar, Esherichia coli ve Staphylococcus aureus üremelerinin üzerine istatistik açıdan belirgin derecede etkili olduğu tespit edilmiştir.

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“…The missense p.Phe279Tyr mutation is one of the most promising markers to improve protein content and milk yield (Sun et al, 2009). Other studies reported the effect of this polymorphism on feed intake, feed conversion, and traits related to energy balance (Banos et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Genetic markers of body composition and carcass quality in grazing Brangus steers

Baeza¹,

Corva²,

Soria³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. The somatotropic axis is a major regulatory pathway of energy metabolism during postnatal growth in mammals. Genes involved in this pathway influence many economically important traits. The association of selected SNPs in these genes with carcass traits was examined in grazing Brangus steers. These traits included final live weight, ultrasound backfat thickness (UBFT), rib-eye area, kidney fat weight, hot carcass weight, and intramuscular fat percentage (%IMF). Genomic DNA (N = 246) was genotyped for a panel of 15 tag SNPs located in the growth hormone receptor (GHR), insulin-like growth factor I, insulin-like growth factor-binding protein 6, pro-melanin- Genetic markers of carcass traits in grazing Brangus steers concentrating hormone, suppressor of cytokine signaling 2, and signal transducer and activator of transcription 6 (STAT6) genes. Allelic and haplotype frequencies were compared with those of a sample of European breeds (N = 177 steers). Two tag SNPs in the GHR affected %IMF; one of them (ss86273136) was also strongly associated with UBFT (P < 0.003). The frequency of the most favorable GHR haplotype for %IMF was lower in Brangus steers. Moreover, the haplotype carrying two unfavorable alleles was present at a frequency of 31% in this group. Four tag SNPs on STAT6 had a significant effect on UBFT. One of these, SNP ss115492467, was also associated with %IMF. The STAT6 haplotype, including all the alleles favoring UBFT, was the most abundant variant (34%) in the European cattle, while it had a frequency of 14% in the Brangus steers. The four less favorable variants (absent in the European cattle) were found at a frequency of 38% in the Brangus steers. These results support the association of GHR and STAT6 SNP with carcass traits in composite breeds, such as Brangus, under grazing conditions.

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Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population

Cited by 42 publications

References 11 publications

Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

Comparision of DGAT1 K232A Polymorphism and its Effects on some Milk Quality Parameters in Holstein and Native Black Race Cattles

Genetic markers of body composition and carcass quality in grazing Brangus steers

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