Effects of ID‐alG^™ on Weight Management and Body Fat Mass in High‐Fat‐Fed Rats

Abstract

Seaweed extract of Ascophyllum nodosum, ID-alG™, was evaluated for its chronic effects on weight management in high-fat-fed Sprague-Dawley rats. ID-alG™ was orally administered daily during 9 weeks at doses of 40 and 400 mg/kg/day with fat-enriched diet (FED) in comparison with two control groups consuming standard diet (negative control) or FED (positive control) and orally treated with vehicle. Body weight, percentage of body fat mass and lipid parameters were measured. After 9 weeks, the oral administration of ID-alG™ at both doses decreased significantly the mean body weight gains (MBWG) of rats submitted to the FED in comparison to the positive control (-6.8% and -11.8%). ID-alG™ at both doses improved significantly the MBWG of rats and decreased significantly the percentage of body fat mass of rats (-9.8% and -19.0%), in comparison to the positive control. In the same way, the triglyceride blood level was also significantly improved for the dose of 400 mg/kg/day (-30.6% vs. +49.9% for the positive control); and the dose of 40 mg/kg/day just lead to a trend. Moreover, in both controls and ID-alG™-treated groups, total cholesterol, LDL and HDL blood levels were not modified. The seaweed extract of Ascophyllum nodosum, ID-alG™, demonstrated beneficial effects on weight management of rats submitted to a high-fat diet.

Water Soluble Vitamin E Administration in Wistar Rats with Non-alcoholic Fatty Liver Disease

“…No significant differences in HDL-C were observed at the end of the study between the 3 experimental groups. This finding is similar to other studies [40]. However, contradictory results have also been reported where HF feeding significantly decreased HDL-C levels [41].…”

Anti-Obesity Effects of Macroalgae

“…Terpend et al [27] carried out a study in female Sprague-Dawley rats distributed in four experimental groups: ND group (fed a normal diet), HFD group (fed a high-fat diet) and two additional groups fed the same high-fat diet and supplemented by gavage with 40 mg/kg/day or 400 mg/kg/d of ID-alG™, a seaweed extract obtained from Ascophyllum nodosum in which grape extract is used as carrier. The experimental period length was of 8 weeks.…”

Evaluation of the satiating properties of a nutraceutical product containing Garcinia cambogia and Ascophyllum nodosum extracts in healthy volunteers

“…A novel compound present in LIS is ID-alG, an ingredient obtained from the thallus of the brown alga Ascophyllum nodosum using Vitis vinifera grape extract as a carrier (<5%). 9 According to Terpend et al, ID-alG is rich in polyphenols, capable of inhibiting intestinal a-amylase and lipase enzymes that could lead to a reduction in glucose and fat absorption rate. Meanwhile, to our knowledge, there are no published studies that have evaluated the potential satiating properties of ID-alG in humans, the reported inhibition in a-amylase activity looks promising, considering that a reduction in glucose absorption ratio might prolong glucose delivery from the intestine and, hence, delay glucopaenia-related hunger signals.…”

“…According to results from a study carried out in high fat fed rats, ID-alG (a seaweed extract rich in polyphenols derived from phloroglucinol) has inhibitory properties of digestive enzymes such as lipase and a-amylase, capable of reducing fat and carbohydrate absorption rates from the diet. 9 Moreover, it has Food & Function PAPER been reported that consuming Ascophyllum nodosum enriched bread reduces energy intake in obese subjects, 10 suggesting that consumption of this seaweed isolate might also lead to a reduction in energy intake by modulating feelings of hunger and satiety, although the effects of its non-ber extracts have not been evaluated.…”