Effects of Irradiation on the [Methyl-3H]Choline Uptake in the Human Prostate Cancer Cell Lines LNCaP and PC3

Holzapfel, Klaus; Müller, Sebastian; Seidl, Christof; Grosu, Anca‐Ligia; Schwaiger, Markus; Senekowitsch–Schmidtke, Reingard

doi:10.1007/s00066-008-1799-1

Cited by 10 publications

(3 citation statements)

References 38 publications

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“…The role of radical-dose radiation therapy (RT) has been established in the management of nonmetastatic prostate cancer [1,13]. It has been shown that there is a improvement in both biochemical and clinical local control when doses > 76 Gy are delivered [23,26,27]. This makes it necessary to establish a reliable way to control the toxicity to the organs at risk (OARs) and, in particular, rectal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

et al. 2009

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“…Regarding RT, Holzapfel et al have studied the effect of 6 Gy of radiation on PC3 and LNCaP cells, in vitro ( 64 ). Radiation-induced effects were variable with a transient increase in radiotracer uptake in androgen-independent PC3 cells but a decrease in androgen-dependent LNCaP cells.…”

Section: Overview Of Pathways Traced By Pet Imagingmentioning

confidence: 99%

Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring

Challapalli¹,

Aboagye

2016

Front. Oncol.

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Cancer cells do reprogram their energy metabolism to enable several functions, such as generation of biomass including membrane biosynthesis, and overcoming bioenergetic and redox stress. In this article, we review both established and evolving radioprobes developed in association with positron emission tomography (PET) to detect tumor cell metabolism and effect of treatment. Measurement of enhanced tumor cell glycolysis using 2-deoxy-2-[18F]fluoro-D-glucose is well established in the clinic. Analogs of choline, including [11C]choline and various fluorinated derivatives are being tested in several cancer types clinically with PET. In addition to these, there is an evolving array of metabolic tracers for measuring intracellular transport of glutamine and other amino acids or for measuring glycogenesis, as well as probes used as surrogates for fatty acid synthesis or precursors for fatty acid oxidation. In addition to providing us with opportunities for examining the complex regulation of reprogramed energy metabolism in living subjects, the PET methods open up opportunities for monitoring pharmacological activity of new therapies that directly or indirectly inhibit tumor cell metabolism.

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“…En este estudio, hemos aplicado la monitorización celular en tiempo real basada en la impedancia para evaluar el potencial de la combinación de enzalutamida y radioterapia en dos líneas celulares de cáncer de próstata humano (células LNCaP, sensibles a Enzalutamida y células PC-3, resistentes a Enzalutamida). Estas dos líneas celulares se usan ampliamente en la evaluación preclínica de los tratamientos para el cáncer de próstata (224,225).…”

Section: Discussionunclassified

Enzalutamida como radiopotenciador de líneas celulares de cáncer de próstata

Aguirre¹

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En este trabajo evaluamos el papel de enzalutamida como potenciador de la radioterapia en líneas celulares de cáncer de próstata, sirviendo como experimento de apoyo de investigación básica para investigación clínica. En este proyecto, proponemos estudiar este tratamiento combinado en dos líneas celulares humanas de cáncer de próstata representativas, LNCaP y PC3. Los objetivos concretos son los siguientes: analizar el efecto del tratamiento con enzalutamida antes de la radioterapia sobre la proliferación de células tumorales prostáticas evaluando si existe un efecto sinérgico entre ambas; comprobar el grado de apoptosis conseguido tras la combinación del tratamiento; y abordar el potencial de la tecnología de monitorización en tiempo real (RTCA) para probar si el régimen terapéutico combinatorio de radioterapia con enzalutamida en las líneas celulares de cáncer de próstata puede justificar su aplicación de esta combinación en pacientes con cáncer de próstata localizado.

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Effects of Irradiation on the [Methyl-3H]Choline Uptake in the Human Prostate Cancer Cell Lines LNCaP and PC3

Cited by 10 publications

References 38 publications

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring

Enzalutamida como radiopotenciador de líneas celulares de cáncer de próstata

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