Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

Abstract

In this study, we explored the effect of Lactobacillus plantarum FZU3013-fermented Laminaria japonica (LPLJ) supplementation to prevent hyperlipidaemia in rats fed with a high-fat diet (HFD). The results indicate that LPLJ supplementation improved serum and hepatic biochemical indicators (p < 0.05), elevated short-chain fatty acid levels, reduced HFD-induced accumulation of lipid droplets in the liver, modulated the relative abundance of some microbial phylotypes, and reduced hyperlipidaemia in HFD-fed rats by adjusting the aminoacyl-tRNA, phenylalanine, tyrosine, and tryptophan biosynthetic pathways, as well as the phenylalanine, D-glutamine and D-glutamate, and glutathione metabolic pathways. Additionally, hepatic mRNA levels of the genes involved in lipid metabolism and bile acid homeostasis were significantly reduced by LPLJ intervention (p < 0.05). These results suggest that LPLJ has a positive effect on modulating lipid metabolism and has the potential to be a functional food that can help prevent hyperlipidaemia.

From Function to Metabolome: Metabolomic Analysis Reveals the Effect of Probiotic Fermentation on the Chemical Compositions and Biological Activities of Perilla frutescens Leaves

“…The results showed that probiotic fermentation had obvious implications for the chemical components and functional activities of PFL, and it showed an overall trend of rising first and then falling. This might be attributed to the metabolism effect of microorganisms, and similar results were also reported in other studies ( 27 , 48 , 49 ). As is well known, for plants, fruits, or vegetables, their phytochemical concentrations and biological activities during the fermentation process are generally affected by the fermentation substrate, strains, and fermentation time ( 50 ).…”

“…It is known that microorganisms during the fermentation process could release various enzymes that could disrupt the major components of the plant cell wall, such as cellulose, hemicellulose, pectin, lignin, and protein, and promote the transformation of nutrients and hydrolysis of biological macromolecules, as well as increase the content of bioactive substances ( 49 ). On the other hand, organic matter and protein in PFL provide a partial CN source for microbial fermentation.…”

The Mechanisms of the Potential Probiotic Lactiplantibacillus plantarum against Cardiovascular Disease and the Recent Developments in its Fermented Foods

“…plantarum WW could regulate intestinal flora and lower cholesterol levels. Hu, Zheng, et al [ 128 ] found that Lb. plantarum FZU3013 -fermented Laminaria japonica could affect the expression of genes involved in lipid metabolism and bile acid homeostasis in rats.…”

The efficacy and safety of Laminaria japonica for metabolic syndrome

“…bioactive compounds, such as proteins, iodine, vitamins, and polysaccharides, has shown efficacy in the prevention and treatment of lifestyle-related diseases, including hyperlipidemia, [10] obesity, [11] cancer, [12] and others. [13] In the present study protocol, we will systematically review randomized controlled clinical and experimental studies to summarize the current evidence on the efficacy and safety of LJP for the treatment of metabolic syndrome.…”

“… [7] The brown seaweed Laminaria japonica (LJP), also known as kelp, sea tangle, kombu or kunbu in Japanese and Dashima in Korea, is a traditional medicine and food in Asia because of its pharmacological and biochemical properties. [ 8 , 9 ] LJP containing various bioactive compounds, such as proteins, iodine, vitamins, and polysaccharides, has shown efficacy in the prevention and treatment of lifestyle-related diseases, including hyperlipidemia, [10] obesity, [11] cancer, [12] and others. [13] …”