Effects of linalool and eugenol on the survival of Leishmania ( L .) infantum chagasi within macrophages

Dutra, Fernando L.; Oliveira, Maurício M.; Santos, Reinaldo Sousa Dos; Silva, Wagner Seixas; Alviano, Daniela Sales; Vieira, Danielle P.; Lopes, Angela H.

doi:10.1016/j.actatropica.2016.08.026

Cited by 27 publications

(24 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dutra et al have already examined leishmanicidal effect of linalool on L. infantum chagasi . However when axenic amastigotes were treated with linalool, IC 50 was 550 µg/mL [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned previously, eugenol was characterized as the major compound (86.5%) of the most interesting EO extracted from our Vietnamese sample of O. gratissimum . Literature data indicated a moderate effect on L. amazonensis and a less interesting activity against L. infantum chagasi of eugenol [ 23 , 24 , 25 ]. On L. donovani , along with a moderate in vitro activity, in vivo effect of eugenol (emulsified) was determined.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants

Beaufay

Nghiêm

et al. 2017

Molecules

View full text Add to dashboard Cite

Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana (Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated. Their composition was determined by GC-MS and GC-FID. Our results indicated that EOs extracted from Cinnamomum cassia, Zingiber zerumbet, Elsholtzia ciliata and Amomum aromaticum, possessed a moderate anti-leishmanial activity, with IC50 values of 2.92 ± 0.08, 3.34 ± 0.34, 8.49 ± 0.32 and 9.25 ± 0.64 nL/mL respectively. However, they also showed cytotoxicity with SI < 10. The most promising EO was extracted from Ocimum gratissimum, displaying an IC50 of 4.85 ± 1.65 nL/mL and SI > 10. It contained 86.5% eugenol, which was demonstrated to be effective on Lmm with IC50 of 2.57 ± 0.57 nL/mL and not toxic on mammalian cells, explaining the observed activity.

show abstract

“…Dutra et al have already examined leishmanicidal effect of linalool on L. infantum chagasi . However when axenic amastigotes were treated with linalool, IC 50 was 550 µg/mL [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants

Beaufay

Nghiêm

et al. 2017

Molecules

View full text Add to dashboard Cite

show abstract

“…Linalool also contains both enantiomers in plant extract [6,8]. The biological activities of linalool have been reported in racemate and each isomer, e.g., antileishmanial activity in rac-linalool [9], anesthetic activity in (S)-(+)-linalool [10], and acaricidal activity in (R)-(−)-linalool [11]. These enantiomers have different fragrance property [6,8] and biological activity between (R)-(−)-linalool and (S)-(+)-linalool [12].…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric analysis of monoterpenes in Oba-kuromozi (Lindera umbellata var. membranacea)

et al. 2018

View full text Add to dashboard Cite

“…A range of therapies exists for the treatment of inflammation-driven diseases, which can be summarized as non-steroidal anti-inflammatory drugs (NSAIDs), corticoids and steroidal-related drugs (Ward et al, 2008). Despite of these notable successes, there are still major unmet medical needs in the treatment of inflammatory diseases and the development of new anti-inflammatory drugs features, prominently in the research portfolios of most pharmaceutical and biotech companies (Dutra et al, 2016;Ward et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Natural products (NPs) continue to be an invaluable source of new chemical entities for the treatment of several diseases, including inflammatory disorders, which are still challenges in the modern medicine, with currently available drugs often not being effective (Dutra et al, 2016;Kondamudi et al, 2013;Li and Vederas, 2009;Suroowan and Mahomoodally, 2018). Flavour and fragrance components common to human diets that have been designated Generally Recognized as Safe (GRAS) by the US Food and Drug Administration (FDA), including terpenes (Juergens, 2014).…”

Section: Introductionmentioning

confidence: 99%

Monoterpenes modulating cytokines - A review

Quintans

Saravanan

Heimfarth

et al. 2019

Food and Chemical Toxicology

View full text Add to dashboard Cite

Inflammatory response can be driven by cytokine production and is a pivotal target in the management of inflammatory diseases. Monoterpenes have shown that promising profile as agents which reduce the inflammatory process and also modulate the key chemical mediators of inflammation, such as pro and anti-inflammatory cytokines. The main interest focused on monoterpenes were to develop the analgesic and anti-inflammatory drugs. In this review, we summarized current knowledge on monoterpenes that produce anti-inflammatory effects by modulating the release of cytokines, as well as suggesting that which monoterpenoid molecules may be most effective in the treatment of inflammatory disease. Several different inflammatory markers were evaluated as a target of monoterpenes. The proinflammatory and antiinflammatory cytokines were found TNF-α, IL-1β, IL-2, IL-5, IL-4, IL-6, IL-8, IL-10, IL-12 IL-13, IL-17A, IFNγ, TGF-β1 and IFN-γ. Our review found evidence that NF-κB and MAPK signaling are important pathways for the anti-inflammatory action of monoterpenes. We found 24 monoterpenes that modulate the production of cytokines, which appears to be the major pharmacological mechanism these compounds possess in relation to the attenuation of inflammatory response. Despite the compelling evidence supporting the anti-inflammatory effect of monoterpenes, further studies are necessary to fully explore their potential as anti-inflammatory compounds.

show abstract

Effects of linalool and eugenol on the survival of Leishmania ( L .) infantum chagasi within macrophages

Cited by 27 publications

References 44 publications

In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants

In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants

Enantiomeric analysis of monoterpenes in Oba-kuromozi (Lindera umbellata var. membranacea)

Monoterpenes modulating cytokines - A review

Contact Info

Product

Resources

About