Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

Huang, Xin; Gong, Renmin; Lin, Jen‐Der; Li, Ronghui; Xiao, Liying; Duan, Wei; Fang, Dingzhi

doi:10.5582/bst.2011.v5.5.198

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…Each diet was designed to have constant ratios of proteins, fats, and carbohydrates to total energy. As reported before [19], the percentage of proteins, fats and carbohydrates in the washout diet were 15.8%, 30.1% and 54.1% while in the HC/LF diet, the proportions were 16.2%, 13.8% and 70.1%, respectively (Table 1). All the meals were prepared with local foods.…”

Section: Methodssupporting

confidence: 75%

“…While dietary intervention has become an effective method of primordial prevention on dyslipidemia [23], the HC/LF diet was found to have different effects on plasma lipids in different subjects [19,24]. The mechanism of the discrepancy has not been elucidated yet.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 209 university students aged 20–30 years were recruited and 60 of them who met the recruitment criteria described previously [19] entered the study. Briefly, all of them were apparently healthy as indicated by the medical questionnaire, physical examination and laboratory tests.…”

Section: Methodsmentioning

confidence: 99%

“…, at baseline), of the day before the HC/LF diet and of the day after the HC/LF diet, 12 hour-fasting venous blood samples were collected between 7:00 and 8:00 a.m., and height, weight, waist circumference, hip circumference, heart rate and blood pressure, including the systolic blood pressure (SBP) and the diastolic blood pressure (DBP) (using a standard mercury sphygmomanometer with 1 of 5 cuff sizes chosen on the basis of the circumference of the participant’s arm), were measured. Plasma TG, TC, HDL-C, LDL-C, apolipoprotein A-I (Apo A-I), apolipoprotein B-100 (Apo B-100) and glucose were analyzed using the routine methods described previously [19]. Average value of three independent measurements for each variable was used for statistical analyses.…”

Section: Methodsmentioning

confidence: 99%

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Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

Zhu

Lin

Wang

et al. 2014

IJERPH

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To investigate the effects of a high-carbohydrate and low-fat (HC/LF) diet on plasma lipids and apolipoproteins (Apos) of healthy Chinese Han youth with different genotypes of lipoprotein lipase gene (LPL) rs326, 56 subjects were given a washout diet of 30.1% fat and 54.1% carbohydrate for seven days, followed by the HC/LF diet of 13.8% fat and 70.1% carbohydrate for six days, with no total energy restriction. Plasma glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Apo B-100 and Apo A-I were analyzed at baseline and before and after the HC/LF diet. The results show that, when compared with before the HC/LF diet, only the male G carriers experienced increased HDL-C (p = 0.008) and Apo A-I (p = 0.005) after the HC/LF diet. Decreased TC in both males and females and increased TG in females were found regardless of the genotype after the HC/LF diet. LDL-C decreased in all the subjects although the decrease was not significant in the female G carriers. These results demonstrate that the G allele of LPL rs326 associates with the elevated levels of HDL-C and Apo A-I after the HC/LF diet in males of the healthy Chinese Han Youth.

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Section: Methodssupporting

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

Zhu

Lin

Wang

et al. 2014

IJERPH

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“…The components of the washout and the high-CHO diets have been described before [36]. Briefly, 30.1% of the total energy of the washout diet was derived from fat, 54.1% from carbohydrates, and 15.8% from proteins.…”

Section: Methodsmentioning

confidence: 99%

Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a high-carbohydrate and low-fat diet in healthy youth

et al. 2014

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BackgroundDiets are the important players in regulating plasma lipid profiles. And the R219K polymorphism at the gene of ATP-binding cassette transporter 1(ABCA1) was reported to be associated with the profiles. However, no efforts have been made to investigate the changes of lipid profiles after a high-carbohydrate and low-fat diet in different subjects with different genotypes of this polymorphism. This study was to evaluate the effects of ABCA1 R219K polymorphism on serum lipid and apolipoprotein (apo) ratios induced by a high-carbohydrate/low-fat (high-CHO) diet. After a washout diet of 54.1% carbohydrate for 7 days, 56 healthy young subjects (22.89 ± 1.80 years old) were given a high-CHO diet of 70.1% carbohydrate for 6 days. Height, weight, waist circumference, hip circumference, glucose (Glu), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apoA-1 and apoB-100 were measured on the 1st, 8th and 14th days of this study. Body mass index (BMI), waist-to-hip ratios (WHR), log(TG/HDL-C), TC/HDL-C, LDL-C/HDL-C and apoA-1/apoB-100 were calculated. ABCA1 R219K was analyzed by a PCR-RFLP method.Results The results indicate that the male subjects of all the genotypes had higher WHR than their female counterparts on the 1st, 8th and 14th days of this study. The male K carriers had higher log(TG/HDL-C) and TC/HDL-C than the female carriers on the 1st and 14th days, and higher LDL-C/HDL-C on the 14th day. When compared with that on the 8th day, TC/HDL-C was decreased regardless of the genotypes and genders on the 14th day. Log(TG/HDL-C) was increased in the males with the RR genotype and the female K carriers. Lowered BMI, Glu and LDL-C/HDL-C were found in the male K carriers, but only lowered BMI in the female K carriers and only lowered LDL-C/HDL-C in the females with the RR genotype.Conclusions These results suggest that ABCA1 R219K polymorphism is associated differently in males and females with elevated log(TG/HDL-C) and decreased LDL-C/HDL-C induced by the high-CHO diet.

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Gene–Diet Interactions in Cardiovascular Disease

Dimitriou

Dedoussis

2012

Curr Nutr Rep

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Cardiovascular disease (CVD), the leading cause of mortality worldwide, results from a complex interplay between genetic and environmental factors. Genetic studies identified genetic variants providing insights into the pathogenesis and treatment of the disease. However, the mechanisms linking the genotypic and phenotypic expression remain to be elucidated. Gene-diet interaction studies attempt to elucidate how a modifiable factor interacts with the genetic background. The knowledge gained thus far confers to small increments of CVD risk and cannot explain the molecular mechanisms of the disease. Epigenetic studies attempt to elucidate the molecular pathways affected by an environmental stimulus, such as dietary exposure. The epigenomic changes and their link to gene-diet interactions remain a challenging area for research. Understanding the complex interplay among the epigenome, genome, and dietary exposure should lead to accurate prediction, prevention, or treatment of the disease.

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Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth

Cited by 9 publications

References 27 publications

Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a high-carbohydrate and low-fat diet in healthy youth

Gene–Diet Interactions in Cardiovascular Disease

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