1996
DOI: 10.1248/bpb.19.758
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Effects of Liposome Size on Penetration of dl-Tocopherol Acetate into Skin.

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Cited by 19 publications
(9 citation statements)
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“…Small liposomes (diameter, < 50 nm) are very unstable and prone to fuse with one another or biological membranes due to their high surface tension. In contrast, large liposomes (diameter, >200 nm) are usually stable but may have difficulty to penetrate through skin for topical drug delivery, and thus fail to show advantages over free drugs [34,35]. Liposomes with moderate size range (50–100 nm) will have relatively prolonged stability [36], preserve the capability to fuse with bacterial or cell membranes, and possess good skin penetration ability [37].…”
Section: Resultsmentioning
confidence: 99%
“…Small liposomes (diameter, < 50 nm) are very unstable and prone to fuse with one another or biological membranes due to their high surface tension. In contrast, large liposomes (diameter, >200 nm) are usually stable but may have difficulty to penetrate through skin for topical drug delivery, and thus fail to show advantages over free drugs [34,35]. Liposomes with moderate size range (50–100 nm) will have relatively prolonged stability [36], preserve the capability to fuse with bacterial or cell membranes, and possess good skin penetration ability [37].…”
Section: Resultsmentioning
confidence: 99%
“…Small size of liposomes can accelerate transdermal penetration of drug. Liposomes having size about 30 nm promoted faster penetration of α-TOA in comparison to 150-nm liposomes [101]. Transferosomes represent advanced transdermal delivery systems for the drugs.…”
Section: Administration Routes For Delivery Of Liposomal Vitamin E Anmentioning
confidence: 99%
“…Topical administration can certainly be long term and is of considerable interest to the cosmetic industry in treating specific 12 skin disorders such as psoriasis. Alpha-tocopheryl acetate in liposomes has been found to have a better dermal absorption than free alpha-tocopheryl acetate (42). Topical administration of anüoxidant liposomes could also be useful in situations where individuals were exposed to toxic substances (e.g., chemical warfare agents) causing skin damage by free radical mechanisms.…”
Section: Modes Of Administrationmentioning
confidence: 99%