Effects of local anesthesia of the cerebellum on classical fear conditioning in goldfish

Yoshida, Masayuki; Hirano, Ruriko

doi:10.1186/1744-9081-6-20

Cited by 31 publications

(29 citation statements)

References 40 publications

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“…Lastly, the authors reported that the observation of normal swimming activity or obstacle avoidance indicated that cerebellum lesions did not produce any observable motor deficit, and the lesions did not interfere with the occurrence of unconditioned motor or emotional responses. Rodriguez et al (2005), Yoshida and Hirano (2010), and Gómez et al (2010) reached the same conclusion; the functional involvement of the teleost's cerebellum in learning and memory is very similar to that of mammals. Subsequently, the authors suggest that the cognitive and emotional functions of the cerebellum may have evolved early in vertebrate evolution, having been conserved along the phylogenetic history of the extant vertebrate groups.…”

Section: Associative Learningsupporting

confidence: 58%

“…Contrasting the lack of effects of telencephalic ablations, research conducted by Gómez, Durán, Salas, and Rodríguez (2010), Yoshida and Hirano (2010), and Rodríguez et al (2005), exemplifies cumulated evidence supporting the notion that teleost's cerebellum is essential for the classical conditioning of several types of behavior (in the same way that it is for mammals). Rodriguez et (2010) analyzed the involvement of the cerebellum in the classical conditioning of motor and emotional responses and on spatial cognition.…”

Section: Associative Learningmentioning

confidence: 99%

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Mecanismos neuronales del aprendizaje en los peces teleósteos

Hurtado-Parrado¹

2010

Univ Psychol

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a b s t r a C tTwo predominant approaches for studying the neurobiology of learning in fish are reviewed: brain lesions and chemical stimulation. Habituation, sensitization, Pavlovian Conditioning, spatial behavior, and emotional learning are the specific processes analyzed. Regarding the effect of brain lesions, telencephalic ablations produced impairment of habituation learning; conversely, cerebellum lesions caused deficiencies in classical conditioning of eye-retraction and spatial learning (similar effects observed in mammals suggest that the functions of the cerebellum may have evolved early in vertebrate history). Medium Pallium (MP) areas have been identified as critical for emotional learning in fish. Furthermore, neurobehavioral functions of MP seem to be similar to the functions of the amygdala in mammals. Relating to neurochemical processes, NMDA receptor antagonists affected the acquisition of avoidance and fear conditioning in a dose-dependent manner. Alternatively, Nitric Oxide (NO) and cyclic Guanosine Monophosphate (cGMP) seem to be involved in the consolidation process of emotional learning. Keywords authorNeurobehavioral functions, neurochemical functioning, teleost fish, learning processes, spatial learning, Medium Lateral Pallium. Keywords plusTeleost Fish, Neurochemistry, Cerebrum, Injuries. r e s u m e n Se revisaron dos aproximaciones al estudio de la neurobiología del aprendizaje en peces teleósteos: lesiones cerebrales y estimulación química. Respecto al efecto de lesiones cerebrales, la literatura reporta que las ablaciones del telencéfalo producen deficiencias en habituación, mientras que las lesiones en el cerebelo afectan el condicionamiento clásico de retracción ocular y aprendizaje espacial (efectos similares observados en mamíferos sugieren que las funciones del cerebelo pudieron haber evolucionado tempranamente en la historia de los vertebrados). Áreas del Medium Pallium (MP) parecen ser vitales en el aprendizaje emocional de los peces; más aún, las funciones del MP aparentan ser similares a las de la amígdala en mamíferos. Con respecto a procesos neuroquímicos, los antagonistas de los receptores NMDA, mostraron afectar la adquisición de condicionamiento de evitación y miedo. Por último, el óxido nítrico y el guanosín monofosfato cíclico han sido relacionados con los procesos de consolidación del aprendizaje emocional. Palabras clave autorFuncionamiento neuroquímico, peces teleósteos, aprendizaje espacial, procesos de aprendizaje, Medium Pallium Lateral.

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Section: Associative Learningsupporting

confidence: 58%

Section: Associative Learningmentioning

confidence: 99%

Mecanismos neuronales del aprendizaje en los peces teleósteos

Hurtado-Parrado¹

2010

Univ Psychol

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Section: Cerebellummentioning

confidence: 99%

“…Therefore, these might be homologues of the mammalian pontine nucleus. Some of these relay points will convey higher cognitive information between the telencephalon and cerebellum, and indeed, fish cerebellum participates in fear conditioning (Yoshida & Hirano 2010) or spatial cognition (Dur an et al 2014). Further investigations are required to determine whether telencephalo-cerebellar pathways in teleosts are primordial cerebral cortex-cerebrocerebellum circuits and whether the teleost cerebellum participates in various cognitive functions.…”

Section: Cerebellummentioning

confidence: 99%

Dopamine system, cerebellum, and nucleus ruber in fish and mammals

Matsui

2017

Dev Growth Differ

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Small teleost fish including zebrafish and medaka have been used as animal models for research because of their small body size, vast amounts of eggs produced, their rapid development, low husbandry costs, and transparency during embryogenesis. Although the body size and appearance seem different, fish and mammals including human still possess anatomical and functional similarities in their brains. This review summarizes the similarities of brain structures and functions between teleost fish and mammalian brains, focusing on the dopamine system, functional regionalization of the cerebellum, and presence of the nucleus ruber.

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“…Fish learn to avoid electric shocks usually in one or a few trials (e.g. Yoshida and Hirano, 2010). This avoidance behaviour persists for up to 3 days (Dunlop et al, 2006), but after 3 days of food deprivation fish will risk entering the shock zone to obtain food (Millsopp and Laming, 2008).…”

Section: Pain In Fishmentioning

confidence: 99%

Pain in aquatic animals

Sneddon

2015

Journal of Experimental Biology

176

102

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Recent developments in the study of pain in animals have demonstrated the potential for pain perception in a variety of wholly aquatic species such as molluscs, crustaceans and fish. This allows us to gain insight into how the ecological pressures and differential life history of living in a watery medium can yield novel data that inform the comparative physiology and evolution of pain. Nociception is the simple detection of potentially painful stimuli usually accompanied by a reflex withdrawal response, and nociceptors have been found in aquatic invertebrates such as the sea slug Aplysia. It would seem adaptive to have a warning system that allows animals to avoid lifethreatening injury, yet debate does still continue over the capacity for non-mammalian species to experience the discomfort or suffering that is a key component of pain rather than a nociceptive reflex. Contemporary studies over the last 10 years have demonstrated that bony fish possess nociceptors that are similar to those in mammals; that they demonstrate pain-related changes in physiology and behaviour that are reduced by painkillers; that they exhibit higher brain activity when painfully stimulated; and that pain is more important than showing fear or anti-predator behaviour in bony fish. The neurophysiological basis of nociception or pain in fish is demonstrably similar to that in mammals. Pain perception in invertebrates is more controversial as they lack the vertebrate brain, yet recent research evidence confirms that there are behavioural changes in response to potentially painful events. This review will assess the field of pain perception in aquatic species, focusing on fish and selected invertebrate groups to interpret how research findings can inform our understanding of the physiology and evolution of pain. Further, if we accept these animals may be capable of experiencing the negative experience of pain, then the wider implications of human use of these animals should be considered.

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Effects of local anesthesia of the cerebellum on classical fear conditioning in goldfish

Cited by 31 publications

References 40 publications

Mecanismos neuronales del aprendizaje en los peces teleósteos

Mecanismos neuronales del aprendizaje en los peces teleósteos

Dopamine system, cerebellum, and nucleus ruber in fish and mammals

Pain in aquatic animals

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