Effects of long-term alachlor exposure on hepatic antioxidant defense and detoxifying enzyme activities in crucian carp (Carassius auratus)

Yi, Xionghai; Ding, Hui; Lu, Yitong; Liu, Haohua; Zhang, Min; Jiang, Wei

doi:10.1016/j.chemosphere.2007.02.035

Cited by 64 publications

(23 citation statements)

References 38 publications

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“…The results are similar to those of Yi et al (2007) and Jin et al (2010) who recorded a marked decrease in GSH content of Carassius auratus and adult female zebra fish, Danio rerio exposed to alachlor and atrazine herbicides, respectively. This may be explained by a direct action of atrazine on GSH synthesis or that GSH has been depleted in scavenging free radical resulting in its conversion to the oxidized form GSSG (Bamela and Richard, 1994).…”

Section: Resultssupporting

confidence: 77%

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Kadry

Amer

Marzouk

et al. 2012

Egypt. J. of Aquatic Biolo. and Fish.

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The present study was planned aiming to investigate the effects of atrazine herbicide exposure on stress biomarkers acetylcholinesterase activity (AchE) and cortisol, oxidative stress responses and the histopathological changes in liver of female Clarias gariepinus and the ameliorative effect of vitamin E supplementation (240mg/kg diet) on the degree of atrazine sublethal toxicity (1.37mg/l) for 6 weeks. Chronic exposure to atrazine revealed a marked inhibition in the activity of AchE. But, significant increase of serum cortisol level was recorded. Moreover, atrazine exposure was associated with a marked induction of oxidative damage in liver tissue as evidenced by increased level of lipid peroxidation (LPO) and reduced glutathione (GSH) content. Atrazine exposure also led to a significant increase in the activities of catalase (CAT) and superoxide dismutase (SOD).Furthermore, histopathological examination of the liver of exposed fish showed dilatation and congestion of blood vessels, fatty degeneration, necrosis and pyknotic nuclei of hepatocytes. However, fish fed diet supplemented with vitamin E exhibited protective effect by minimizing the atrazine-induced toxicity, through measured values more or less similar to the control group fish.

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Section: Resultssupporting

confidence: 77%

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Kadry

Amer

Marzouk

et al. 2012

Egypt. J. of Aquatic Biolo. and Fish.

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show abstract

“…However, HSI significantly reduced at the highest test concentration (2.75 mg/L), at the beginning of Day 10 post exposure. Normal HSI have been reported for: Cyprinus carpio, exposed to alachlor and deltamethrin [9,45], Carassius auratus exposed to alachlor [46], and…”

Section: Discussionmentioning

confidence: 99%

Physiological effects of paraquat in juvenile African catfish Clarias gariepinus (Burchel 1822)

2014

JCLM

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“…Superoxide dismutase catalyzes the transformation of superoxide radicals to H 2 O 2 and O 2 , and is the fi rst enzyme to deal with oxyradicals (Yi et al, 2007). As a result, SOD activity made a counteractive response under oxidative stress.…”

Section: Antioxidant Responsesmentioning

confidence: 99%

Physiological condition status and muscle‐based biomarkers in rainbow trout (Oncorhynchus mykiss), after long‐term exposure to carbamazepine

Li¹,

Žlábek²,

Velíšek³

et al. 2009

J of Applied Toxicology

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Recently, residual pharmaceuticals are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic toxic effects of carbamazepine (CBZ), an anticonvulsant pharmaceutical commonly present in surface and ground water, on physiological condition status and muscle-based biomarkers of rainbow trout were investigated. Fish were exposed at sublethal concentrations of CBZ (1.0 microg l(-1), 0.2 mg l(-1) and 2.0 mg l(-1)) for 42 days. Compared with the control, there was a significant lower (P < 0.05) condition factor in fish exposed at the highest concentration of CBZ (2.0 mg l(-1)), but the hepatosomatic indices in all groups were not significant changes. At lower CBZ concentration (1.0 microg l(-1), 0.2 mg l(-1)), the antioxidant enzyme activities were induced slightly, except catalase, while at the highest concentration (2.0 mg l(-1)) oxidative stress was apparent as reflected by the significant higher lipid peroxidation and protein carbonyls in the fish muscle, associated with a significant inhibition of antioxidant enzymes activities. Moreover, energy metabolic parameters (RNA-DNA ratio, Na(+)-K(+)-ATPase) were significantly inhibited in muscle of the fish exposed at the highest concentration (2.0 mg l(-1)), compared with the control. In short, CBZ-induced physiological and biochemical responses in fish were reflected in parameters measured in this study, which suggest that these biomarkers could be used as potential indicators for monitoring residual pharmaceuticals present in aquatic environment.

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Effects of long-term alachlor exposure on hepatic antioxidant defense and detoxifying enzyme activities in crucian carp (Carassius auratus)

Cited by 64 publications

References 38 publications

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Vitamin E as antioxidant in female african catfish (Clarias gariepinus) exposed to chronic toxicity of atrazine

Physiological effects of paraquat in juvenile African catfish Clarias gariepinus (Burchel 1822)

Physiological condition status and muscle‐based biomarkers in rainbow trout (Oncorhynchus mykiss), after long‐term exposure to carbamazepine

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