Effects of Long-term Boysenberry Juice Intake on Lipid Accumulation in Rats

Abstract

Recently, it has often been reported that certain polyphenols are useful for prevention of obesity. However, few investigations have been conducted on the anti-obesity effects of boysenberry polyphenols, including anthocyanins and ellagic acid. Therefore, we examined whether boysenberry juice BJ would prevent obesity in Wistar rats fed normal and high-fat diets containing 5 BJ for 12 weeks. At the end of the feeding period, our data revealed significant decreases in body weight gain, body fat accumulation, and liver lipid levels, especially triglyceride TG and total cholesterol, in the rats fed diets containing 5 BJ BJ group compared with the rats fed diets without BJ control group. Furthermore, we measured the plasma TG levels in rats fed each test diet after a 20-hour fast, and observed notable reductions in the postprandial plasma TG levels in the BJ group compared with the control group after 3 hours. These results suggest that consumption of BJ has potential preventive effects against obesity induced by a high-fat diet and associated metabolic syndrome.

Boysenberry Polyphenols Suppressed Elevation of Plasma Triglyceride Levels in Rats

“…Thus, consumption of food containing various polyphenols has attracted much attention to prevent obesity caused by a high-fat diet. We have previously reported BBJ significantly lowered plasma TG levels together with active FAS and cholesterol levels in the liver, leading to the suppression of elevations of total body weight and body fat in an obesity rat model induced by a high-fat diet including 30% lard (13). These findings indicate that BBJ contains beneficial components associated with anti-obesity effects.…”

“…We previously reported that long-term feeding of BBJ showed anti-obesity effects in rats served a high-fat diet (13) and significant suppression of postprandial plasma triglyceride (TG) levels were observed together with the lowering of hepatic fatty acid synthase (FAS) activity. Inhibition of TG absorption from gastrointestinal tract is thought to be an effective strategy to prevent obesity.…”

Dietary Anthocyanin-rich Haskap Phytochemicals Inhibit Postprandial Hyperlipidemia and Hyperglycemia in Rats

“…There have been reports that the serum triglyceride levels of guinea pigs fed the HF diet with grape polyphenol for 12 weeks were significantly lowered 31 , and that the increase of serum triglyceride concentrations in rats fed the HF diet with boysenberries lowered because components of boysenberries control or slow fat absorption in the intestine 32 . An antiobesity effect of chlorogenic acid, which is also present in the Haskap phytochemical, has also been reported 33,34 .…”

Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats

“…In accord with these results, Tosca et al showed improved serum triglyceride levels in guinea pigs administered grape polyphenol 19 . Similarly, Noguchi et al showed decreased serum triglyceride concentrations in rats fed boysenberries reflecting inhibition of intestinal fat absorption by boysenberry components 25 . Hence, to assess whether aronia polyphenol phytochemicals such as anthocyanin exert similar effects, we investigated the effect of aronia phytochemicals on pancreatic lipase activity Table 6 .…”