Effects of Long Term Exposure of 900- 1800 MHz Radiation Emitted from 2G Mobile Phone on Mice Hippocampus- A Histomorphometric Study

Mugunthan, N; K, Shanmugasamy; Anbalagan, J; Rajanarayanan, S.; Meenachi, S.

doi:10.7860/jcdr/2016/21630.8368

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Long-term RF-EMR exposure also affects hippocampal morphology, as demonstrated by pathological alterations at light microscopic levels. This study's amplitude of tissue degeneration is comparable with previous studies (35,72,(76)(77)(78)(79). HP and HMEP at higher doses could protect from the neuronal damage caused by the redox instability caused by mobile phone radiation.…”

Section: Discussionsupporting

confidence: 88%

Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats

Saka

Chitra

Narayanasamy

2023

J Herbmed Pharmacol

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Introduction: Radiofrequency electromagnetic radiation (RF-EMR) from mobile phones was reported to cause neurological damage. Hispolon pyrazole (HP) and hispolon monomethyl ether pyrazole (HMEP) were tested for their RF-EMR protection in rats. Methods: Juvenile Wistar albino rats were exposed to the mobile phone generating 2400 MHz radiation with a maximum power output of 2 W/kg (Specific absorption rate 1.6 W/kg) for 90 days at a rate of 2 hours/day, treated with HP and HMEP at 20 and 40 mg/kg body weight. The elevated plus maze (EMT) test was used for anxiety and exploration evaluation, the forced swim test (FST) for depression, the Morris water maze test and Y-maze test for learning and memory. The oxidative stress markers like glutathione, superoxide dismutase (SOD), catalase (CAT), and malonaldehyde (MDA), and the neurotransmitters such as gamma-aminobutyric acid, glutamate, dopamine, and acetylcholinesterase along with histopathology in the cortex, striatum, and hippocampus were evaluated to establish the mechanism of the neuronal alterations of HP and HMEP against RF-EMR-induced damage. Results: In the current investigation, HP at a higher dose of 40 mg/kg and HMEP at both doses significantly reduced the oxidative stress generated by RF-EMR from mobile phones and altered neurobehavioral, neurotransmitter, and histological alterations. Conclusion: Based on the findings, HP and HMEP at a dose of 40 mg/kg are protective agents against long-term, continuous mobile phone use and can be regarded viable therapeutic agents.

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Section: Discussionsupporting

confidence: 88%

Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats

Saka

Chitra

Narayanasamy

2023

J Herbmed Pharmacol

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“…In studies of the rat model, it has been reported that exposure to mobile phones makes negative morphological and histological alternations in the testes (Mugunthan, Shanmugasamy, Anbalagan, Rajanarayanan, & Meenachi, 2016; Salama, Kishimoto, Kanayama, 2010). Cetkin et al have shown that mobile phones, both in speech and in standby condition, lead to degeneration of the germinal epithelial separation from the tunica propria in some seminiferous tubules compared to the control and sham groups (Cetkin et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of melatonin on radiofrequency electromagnetic fields of mobile phone‐induced testicular damage in an experimental mouse model

et al. 2020

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Radiofrequency electromagnetic radiation (RF‐EMR) from mobile devices has undesirable effects on the male reproductive organs. Melatonin with antioxidant potential can help to prevent these damages. Therefore, the aim of this study was to evaluate the protective effect of melatonin on testicular damage induced by RF‐EMR of mobile phone. In this experimental study, 32 adult male BALB/c mice were divided randomly into four groups: control, melatonin (2 mg/kg, for 30 consecutive days, intraperitoneally), RF‐EMR (900 MHz, 100 to 300 MT, 54 to 160 W/m) (4 hr per day, whole body) and melatonin + RF‐EMR groups. One day after the last prescription were evaluated oxidative stress parameters, testosterone level and histopathological assays of the testis. EMR of mobile phone led to the induction of oxidative stress, testicular tissue damage and decreased testosterone. Treatment with melatonin improved oxidative stress parameters such as MDA and GSH, and testis injury score, increased the thickness of the germinal epithelial thickness and diameter of the seminiferous tubule, and decreased testosterone hormone in the EMR‐exposed mice, and these differences were significant(p < .05). Data showed that melatonin with its antioxidant property can decrease oxidative damage induced by RF‐EMR of mobile phones on testis tissue.

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“…Variabel ketebalan lapisan piramidalis area CA1 menunjukan peningkatan ketebalan lapisan meskipun tidak berbeda bermakna antar kelompok. Hal ini sesuai dengan penelitian sebelumnya yang melaporkan bahwa peningkatan ketebalan dapat disebabkan karena terdapatnya edema interstitial setelah paparan telepon seluler, mengakibatkan terjadinya kerusakan endotel, vasodilatasi dan peningkatan permeabilitas vaskuler pada lapisan piramidal area CA1 hipokampus mencit (Mugunthan et al, 2016).…”

Section: Pembahasanunclassified

Perbandingan Gambaran Histologis Lapisan Piramidalis Area Ca1 Hipokampus Mus Musculus yang Dipapar Radiasi Gelombang Elektromagnetik Telepon Seluler 3G dan 4G

Lala,

Sari

2023

JPPP

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Penggunaan telepon seluler telah menjadi kebiasaan dan kebutuhan masyarakat modern saat ini. Penggunaan telepon seluler khususnya dalam menelpon sering kali diletakkan pada kepala kanan. Penggunaan ini dapat memberikan dampak kepada hipokampus, salah satunya pada daerah CA1 yang berfungsi untuk membentuk proses ingatan jangka panjang. Tujuan dari penelitian ini adalah untuk mengetahui dampak paparan gelombang elektromagnetik telepon seluler 3G dan 4G pada lapisan piramidalis CA1 hipokampus model hewan coba mencit. Penelitian ini dilakukan secara eksperimental, menggunakan mencit galur Mus musculus jantan, dengan jumlah total sampel sebanyak 32 mencit. Mencit dibagi menjadi 4 kelompok: kelompok kontrol, kelompok Sham, kelompok perlakuan I (P1), dan kelompok perlakuan II (P2). Perlakuan yang diberikan yaitu berupa paparan 3G dan 4G yang dilakukan 1 jam setiap hari selama 30 hari. Variabel yang diteliti adalah ketebalan lapisan dan jumlah neuron pada lapisan piramidal area CA1 hipokampus mencit. Kemudian otak diambil dan dibuat sediaan histologi menggunakan pewarnaan haematoxylin-eosin dan diamati menggunakan mikroskop cahaya pembesaran 400x serta menggunakan software Cell Sens. Analisis data dilakukan dengan uji Anova satu arah dan uji beda nyata terkecil. Hasil penelititan didapatkan bertambahnya ketebalan lapisan piramidal serta berkurangnya rerata jumlah neuron piramidal area CA1 hipokamopus pada kelompok yang diberikan paparan. Setelah dilakukan analisis statistik, tidak terdapat perbedaan bermakna antar kelompok pada ketebalan lapisan piramidalis area CA1 hipokampus serta terdapat perbedaan yang signifikan rerata jumlah neuron piramidal kelompok yang diberikan paparan dan tidak.

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Effects of Long Term Exposure of 900- 1800 MHz Radiation Emitted from 2G Mobile Phone on Mice Hippocampus- A Histomorphometric Study

Cited by 7 publications

References 12 publications

Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats

Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats

The protective effect of melatonin on radiofrequency electromagnetic fields of mobile phone‐induced testicular damage in an experimental mouse model

Perbandingan Gambaran Histologis Lapisan Piramidalis Area Ca1 Hipokampus Mus Musculus yang Dipapar Radiasi Gelombang Elektromagnetik Telepon Seluler 3G dan 4G

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