Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats

Águila, Márcia Barbosa; Silva, Suzana P Sa; Pinheiro, Alessandra R.; Mandarim-de-Lacerda, Carlos Alberto

doi:10.1097/00004872-200405000-00013

Cited by 38 publications

(27 citation statements)

References 43 publications

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“…In this work control of blood pressure by OV in treated hypertensive group has markedly delayed and slightly improved the histological changes that appeared in untreated hypertensive rats which coincided with Eddouks [29] who have demonstrated the importance of intensive BP control preferably systolic BP less than 130 mmHg to delay progression of renal disease in hypertension and diabetes. The significant drop of systolic BP in treated hypertensive rats with OV as shown in this study agreed and fully explained by Engler [30] and Aguila [31] who reported that OV reduced the BP by reduction of vascular reactivity to noradrenaline blunting the rennin-angiotensinaldosterone system by decreasing adrenal synthesis of aldosterone.…”

Section: Caspase-3 Expressionsupporting

confidence: 90%

Histological, Immunohistochemical and Biochemical Study on the Possible Cardioprotective and Antihypertensive Role of the Flavonoid in Unilateral Renal Artery Ligation of Adult Albino Rats

Mohamed¹

2015

J Cytol Histol

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The blood pressure lowering effect of herbal-rich diet is a necessary dietary lifestyle measure now included the guidelines for the management of arterial hypertension. Flavonoids represent a major class of plant polyphenolics, they have antioxidant effects and show a wide range of pharmacological activities. This study was to clarify the antihypertensive effect of the flavonoid extracted from the Origanum vulgare.Forty five adult male albino rats were classified into three main groups as follows: group I: control. Group II: hypertension was induced by ligation of left renal artery. Group III: hypertension was induced and given OV as 100 mg/kg body weight daily for eight weeks. Blood samples were collected and cardiac sections were stained with H&E and immunohistochemical staining for caspase 3 and Bcl-2.The body weight of control, hypertensive and treated hypertensive groups showed a significant weight gain. Significant increase in creatinine and cholesterol in untreated in contrast to other groups. There was significant reduction of blood pressure (BP) on using OV in contrast to other groups. The hypertension group induced myocardial abnormalities as disruption, vacuolation, inflammation and wide separation of cardiac muscle fibers. Myocyte apoptosis were significantly decreased with OV compared with other groups. Caspases 3 and Bcl2 immunostaining in OV-treated rats were significantly decreased compared with other groups.The supplementation of OV herbetic extract (flavonoid) in hypertensive rats partially prevented such occurred changes, suggesting its possible protective effect against the risk of the progression of cardiovascular diseases during hypertension.

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Section: Caspase-3 Expressionsupporting

confidence: 90%

Histological, Immunohistochemical and Biochemical Study on the Possible Cardioprotective and Antihypertensive Role of the Flavonoid in Unilateral Renal Artery Ligation of Adult Albino Rats

Mohamed¹

2015

J Cytol Histol

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“…Some animal studies have assessed its effect on BP. In general, the results do not show an important beneficial effect of this vegetable oil on BP 38,39 . On the contrary, rats fed diets rich in canola oil lived a shorter time than rats fed with PUFA-enriched diets 40,41 .…”

Section: Feeding Trialsmentioning

confidence: 56%

Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence

Alonso

Ruı́z-Gutı́errez

Martínez‐González

2006

Public Health Nutr.

108

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Diet has an important role in the prevention and treatment of hypertension. In early epidemiological studies, conducted mainly in the USA, monounsaturated fatty acids showed a deleterious association with blood pressure or no relationship at all. However, more recent studies, conducted in Mediterranean countries, have shed new light on this issue. In the present review we summarise the main results of epidemiological studies and feeding trials, and explain the possible mechanisms through which monounsaturated fatty acids, and specifically olive oil as the major dietary source of this type of fat in Mediterranean countries, could exert a favourable effect on blood pressure.

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“…The plant was also reported to possess anti-inflammatory (Ocana-Fuentes et al, 2010) and antimicrobial (Sarac and Ugur, 2008) activities, which could also be supplementing its beneficial effect, as the infection and inflammation are likely to be associated with urolithiasis process. A few studies on the effectiveness of herbal remedies in urolithiasis exists, such as Hernaira hirsute, phylanthusniruri and Hibiscus sabdariffa, which showed promising results in the management of urolithiasis (Aguila et al, 2004;Butterweck and Khan, 2009;Chishti et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Antiurolithic and antihypertensive activities of Origanum vulgaris on urolithic rats

ElSawy¹,

Shaheen²,

Filimban³

et al. 2015

J. Med. Plants Res.

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Origanum vulgaris (Oregano) has been used in the fluky medicinal for treating various diseases including urolithiasis and hypertension. This study was designed to investigate the possible antioxidant and antiurolithic activities of different standardized extracts of Oregano ethanol extract n-hexane, ethyl acetate, and aqueous fraction on rats. The dried hydroalcoholic extract of 70% ethyl alcohol Oregano was suspended in water and successively extracted with n-hexane and ethyl acetate. Each active extract was screened of phytochemical and standardized spectrophotometricaly by estimation of total phenol and total flavonoid content. Antiurolithic and antioxidant activities were studied on live rat model by oral doses of ethylene glycol and NH 4 Cl. The active extracts of Oregano (20 mg/kg) were given to different groups and one group without extracts was used as control. At the end of the experimental period, blood samples were obtained from studying biochemical parameters and a kidney specimen for histopathology using scanning electron microscope. Ethanol extract, n-hexane and aqueous fractions prevented as well as opposed toxic changes, including loss of body weight gain and appetite, raised serum urea, uric acid and creatinine levels, and crystal deposition in the kidneys. These potential urolithitic effects of ethylene glycol should be taken into considerations with close monitoring of kidney function tests at frequent intervals. The oregano antioxidant effect might be more effective in the amelioration of ethylene glycol induced kidney injury and urolithiasis.

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Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats

Cited by 38 publications

References 43 publications

Histological, Immunohistochemical and Biochemical Study on the Possible Cardioprotective and Antihypertensive Role of the Flavonoid in Unilateral Renal Artery Ligation of Adult Albino Rats

Histological, Immunohistochemical and Biochemical Study on the Possible Cardioprotective and Antihypertensive Role of the Flavonoid in Unilateral Renal Artery Ligation of Adult Albino Rats

Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidence

Antiurolithic and antihypertensive activities of Origanum vulgaris on urolithic rats

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