Effects of low and high deprenyl dose on antioxidant enzyme activities in the adult rat brain

Lalkovičová, Maria; Horváthová, Františka; Šulla, I; Mihálik, Jozef; Danielisová, Viera

doi:10.4149/gpb_2016023

Cited by 3 publications

(2 citation statements)

References 27 publications

(31 reference statements)

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“…The ERK family of proteins mainly participate in the processes of proliferation and differentiation, whereas the p38 MAPK family not only have an influence on inflammation and the stress response but can also regulate the normal process of apoptosis ( 39 ). The protein expression levels of ERK and p38 may not change during the time when either cells or osteosarcoma are treated with drugs ( 40 , 41 ). However, if the mRNA expression of certain components is altered, then the expression levels of the ERK and p38 proteins may also be affected by the components in the MAPK/ERK signaling pathway, leading to changes in the expression levels of ERK and p38.…”

Section: Discussionmentioning

confidence: 99%

Proliferation, apoptosis and invasion of human lung cancer cells are associated with NFATc1

Ren

Zhu

et al. 2022

Exp Ther Med

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The expression of nuclear factor of activated T cells c1 (NFATc1) is closely associated with the progression of numerous types of cancer. When NFATc1 expression becomes dysregulated in some types of cancer, this alteration can promote malignant transformation and thereby progression of cancer. NFATc1 expression has been demonstrated to be upregulated in lung cancer cells. This suggests that knockdown of NFATc1 in lung cancer cells may be a therapeutic marker for the treatment of cancer. In the present study, the effects of NFATc1 on the proliferation, apoptosis, invasion and migration of NCI-H1299 and A549 lung cancer cell lines were explored. Lentivirus infection was used to establish a cell model of NFATc1 knockdown in A549 and NCI-H1299 lung cancer cells. Reverse transcription-quantitative PCR was subsequently performed to detect NFATc1 expression in these human lung cancer cells. MTT, wound healing, colony formation and Transwell invasion assays, and flow cytometry were then performed to measure the proliferation, invasion, apoptosis and cell cycle of the cells. Finally, western blot analysis was performed to investigate the mechanism underlying the involvement of NFATc1 in these processes. NFATc1 knockdown was found to significantly inhibit the proliferation, clone formation, migration and invasion of the cells. Furthermore, the cell cycle was arrested at the G 1 phase and the expression levels of the target proteins located downstream in the signaling pathway, namely CDK4, c-Myc, ERK, p38 and N-cadherin, were decreased. Following NFATc1 knockdown, the percentages of apoptotic cells were increased, and the expression levels of Bax, cleaved caspase-3 and E-cadherin were also increased. Taken together, the results of the present study suggested that NFATc1 serves an oncogenic role in lung cancer. In terms of the underlying mechanism, NFATc1 promoted the proliferation of lung cancer cells by inhibiting the MAPK and epithelial-to-mesenchymal transition signaling pathways, suggesting that NFATc1 may be a novel target for therapeutic intervention for the treatment of lung cancer.

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Section: Discussionmentioning

confidence: 99%

Proliferation, apoptosis and invasion of human lung cancer cells are associated with NFATc1

Ren

Zhu

et al. 2022

Exp Ther Med

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“…Recent publications by Mihalik et al [ 29 - 31 ] treat the effect of selegiline on male sperms and the testes.…”

Section: Introductionmentioning

confidence: 99%

Effects on Sperms’ Quality of Selegiline in Aged Rats

Kalász

Thuróczy

Karvaly

et al. 2017

TOMCJ

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Background:Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.Objective:Scouting special and beneficial side effects of selegiline treatment.Method:Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment.Results:Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.Conclusion:Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

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Hydroxycinnamic acid derivatives isolated from hempseed and their effects on central nervous system enzymes

Rea

García-Giménez

Santiago

et al. 2020

International Journal of Food Sciences and Nutrition

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Effects of low and high deprenyl dose on antioxidant enzyme activities in the adult rat brain

Cited by 3 publications

References 27 publications

Proliferation, apoptosis and invasion of human lung cancer cells are associated with NFATc1

Proliferation, apoptosis and invasion of human lung cancer cells are associated with NFATc1

Effects on Sperms’ Quality of Selegiline in Aged Rats

Hydroxycinnamic acid derivatives isolated from hempseed and their effects on central nervous system enzymes

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