Effects of Matrine on proliferation and differentiation in K-562 cells

Zhang, L.P; Jiang, Jiajia; Tam, Jamie; Zhang, Y; Liu, X.S; Xu, Xiaohui; Liu, B.Z; He, Yan

doi:10.1016/s0145-2126(00)00145-4

Cited by 84 publications

(63 citation statements)

References 8 publications

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“…Matrine has been extensively used in China for the treatment of viral hepatitis and cardiac diseases (Liu et al, 2007). Matrine also exhibits inhibition activity toward many tumour cells (such as HeLa cell and gastric cancer MKN45 cell) (Galasso et al, 2006;Luo et al, 2007;Ruan et al, 2006;Zhang et al, 2001Zhang et al, & 2007. In some case, they exhibit significant enhanced antitumour activity, such as 21 to SW480, 22 to HeLa, HepG2 and MCF-7, which exceed matrine and cisplatin, and display synergistic contribution of their components.…”

Section: Matrine-metal Based Anticancer Agentsmentioning

confidence: 99%

Traditional Chinese Medicine Active Ingredient-Metal Based Anticancer Agents

Chen¹,

Liang²,

Liu³

2012

Recent Advances in Theories and Practice of Chinese Medicine

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Section: Matrine-metal Based Anticancer Agentsmentioning

confidence: 99%

Traditional Chinese Medicine Active Ingredient-Metal Based Anticancer Agents

Chen¹,

Liang²,

Liu³

2012

Recent Advances in Theories and Practice of Chinese Medicine

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“…Matrine could induce apoptosis in leukemia U937 and K562 cells (29,30), gastric cancer MKn45 and sgc-7901 cells (23,25), c6 glioma cells (26), multiple myeloma cells (27), and hepatocellular carcinoma H22 cells (28). Matrine can also inhibit invasiveness and metastasis of human malignant melanoma cell line A375 and cervical cancer Hela cells (31,32), and induce differentiation of leukemia K562 cells (20). Furthermore, matrine attenuated cancer cachexia-related symptoms in colon26 tumor-bearing mice probably through inhibiting the production of pro-inflammatory cytokines (33).…”

Section: Introductionmentioning

confidence: 99%

“…recent evidence indicated that matrine may also play an important role in the treatment of tumors. Both in vivo and in vitro studies showed that matrine inhibits the proliferation of tumor cells (20)(21)(22)(23)(24)(25)(26)(27)(28). Matrine could induce apoptosis in leukemia U937 and K562 cells (29,30), gastric cancer MKn45 and sgc-7901 cells (23,25), c6 glioma cells (26), multiple myeloma cells (27), and hepatocellular carcinoma H22 cells (28).…”

Section: Introductionmentioning

confidence: 99%

Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells

Zhang

Chen³

et al. 2011

Oncol Rep

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Abstract. Matrine has a wide range of pharmacological effects including antitumor activity in vitro and in vivo. Autophagy is closely associated with tumors and plays an important role in human tumor suppression, so inducing autophagy is a potential therapeutic strategy in adjuvant chemotherapy. the aim of this study was to investigate whether or not autophagy is involved in antitumor effects of matrine on human gastric cancer sgc-7901 cells, and to further elucidate the underlying molecular mechanisms. sulphorhodamine B (srB) assay was used to examine matrine's cytotoxicity against sgc-7901 gastric cancer cells. the effects of matrine on the cell cycle and apoptosis were measured by flow cytometry, and cellular morphology was observed under an inverted phase contrast microscope and transmission electron microscope. Monodansylcadaverine (MDc) staining was used to detect autophagy. the expression levels of Bax and Beclin 1 in sgc-7901 cells were monitored by real-time quantitative reverse transcription-polymerase chain reaction (rt-pcr). The results showed that matrine significantly inhibited the proliferation of sgc-7901 gastric cancer cells and induced g1-phase cell cycle arrest. Furthermore, both autophagy and apoptosis were activated during the matrine-induced death of sgc-7901 cells. Beclin 1 is involved in matrine-induced autophagy and the pro-apoptotic mechanisms of matrine may be associated with its up-regulation of Bax expression. These findings indicate that matrine is a potent antitumor agent for treating gastric cancer. the ability of matrine to induce autophagy underlines its potential utility as a new gastric cancer treatment modality.

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“…Matrine, with the molecular formula C15H24N20, is a naturally monomer compound of Traditional Chinese Medicine Sophora flavecens Ait with various biological activities such as anti-inflammatory (Hu et al, 1996;Cheng et al, 2006), antiviral (Liu et al, 2003;Long et al, 2004), immunoinhibitory, antifibrotic (Zhang et al, 2001a;Zhang et al, 2001b), analgesic, antiarrhythmic (Zhang et al, 1990;Ai et al, 2001;Xu et al, 2004) and anti-diarrhea effects (Zhang et al, 2001c). Recently, some studies displayed that matrine had potent anti-tumor bioeffect against various cancer cell lines by inhibiting and inducing apoptosis of gastric and cervical cancer cells, prostate cancer cells, leukemia and glioma cells (Hu et al, 2005;Liu et al, 2006;Jiang et al, 2007;Luo et al, 2007;Zhang et al, 2007;Liu et al, 2008;Zhang et al, 2009;Zhang et al, 2012a;Tan et al, 2013;), and also suppressed invasiveness and malignant of melanoma cell line A375 in vitro (Croce and Calin, 2005).…”

Section: Introductionmentioning

confidence: 99%