Effects of methyl methacrylate monomer vapors on respiration and circulation in unanesthetized rats

Blanchet, L.; Bowman, Douglas C.; McReynolds, Hal D.

doi:10.1016/0022-3913(82)90026-9

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…It has been shown that the lungs are the primary organs for the clearance of MMA-m. Prolonged exposure resulted in marked pathologic changes in the lungs, including edema, hemorrhage, and necrosis (4).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Methyl Methacrylate on Nasal Cavity, Lung, and Antioxidant System (An Experimental Inhalation Study)

et al. 2002

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Methyl methacrylate (MMA) is a monomer, commonly used in neurosurger y, orthopedic surgery, and in dental clinics. The adverse effects of this monomer are well described in the literature. This study was designed to evaluate the effects of MMA on nasal cavity, lung, and antioxidant status. For this purpose, two experimental groups of rats were exposed to MMA (at 1000 ppm, 6 h/day, 5 days/week for 4 weeks) by inhalation under poor (group A, n 12) and normal ventilation (group B, n 11) conditions. A control group (group C, n 10) received normal air. Degeneration of olfactory epithelium, bronchopneumonia , interstitial pneumonia , hemorrhage , atelectasis, edema, emphysema , and bronchial epithelial hyperplasia were observed in groups A and B. Emphysema was the most common lesion. Bronchopneumoni a with abscesses was only observed in group A. Glutathione levels were signi cantly decreased and malondialdehyd e levels were signi cantly increased in group A. No signi cant difference was observed in superoxide dismutase levels between the groups. The data presented indicate that before using MMA, adequat e protection systems should be in place to prevent occupationall y related MMA respiratory-tract injuries.

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Section: Introductionmentioning

confidence: 99%

“…There is a limited number of experimental studies of MMA inhalation, which include the histopathological changes in lung and effects on the antioxidant system (4,8). We designed this experimental study to evaluate the effects of MMA on nasal cavity and lung.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Methyl Methacrylate on Nasal Cavity, Lung, and Antioxidant System (An Experimental Inhalation Study)

et al. 2002

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“…proposed that leaching out of the residual monomer from the denture base causes allergic reactions such as burning sensations, stomatitis, edema, and ulceration of the oral mucosa and also has a negative impact on both the mechanical qualities and biocompatibility of these resins. [ 18 ] In the manufacture of removable prostheses, the use of digital technology may minimize such drawbacks. Most dentists feel that digital dentures will be the ultimate tool in future dentistry.…”

Section: Resultsmentioning

confidence: 99%

Knowledge, attitude, and practice of digital dentures among dentists

Sri

Maiti

Sasanka

2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

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The objective of this survey was to evaluate the knowledge, awareness, and practice of digital dentures among dentists. This is a cross-sectional survey conducted from January to February, 2022. Fifteen close-ended questions were framed and circulated among 150 dental practitioners and interns using an online survey form. The responses were collected and statistically analyzed. The results summarize that 95.3% were aware of digital dentures and 4.7% were not. About 60.1% do not use digital workflow, 27% do not have essential equipment, 9.5% were not confident in practicing digital dentures, and 3.4% found that it was inaccurate, showed poor retention, and a well-skilled technician was required. Most dental practitioners are aware of digital dentures. Among all practitioners with postgraduation were more aware of digital dentures than the interns and undergraduate practitioners. Most dentists do not practice digital dentures due to the high initial setup cost and maintenance. The majority of practitioners agree that digital dentures will be the ultimate tool in future dentistry.

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“…3,4 Multiple measures have been taken to decrease contact with MMA, such as gloves, masks and proper ventilation, but this is still not enough to limit the exposure to the widely used MMA and stop the inhalation. 5 For decades, many studies have attempted to determine the degree of toxicity of MMA, including animal and human studies. These studies clari fied the mechanism of MMA toxicity, which can be attri buted to a local interaction between MMA and the mucus membrane of the respiratory system.…”

Section: Introductionmentioning

confidence: 99%

Effect of acute methyl methacrylate vapor inhalation on smokers’ and non-smokers’ respiratory function in a sample of male dentistry students

et al. 2019

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Background. Methyl methacrylate (MMA) is one of the widely used organic monomers in dentistry. It may cause multiple adverse reactions, ranging from allergic reaction to systemic toxicity. Dentistry students are exposed to MMA in an acute manner; however, the concentration of its vapor cannot be estimated well. Objectives. The aim of this study was to evaluate the effect of acute MMA vapor inhalation on the pulmonary function of dental students, both smokers and non-smokers. Material and methods. Thirty-eight male dental students were divided into 2 groups (group 1-smokers and group 2-non-smokers). The lung function parameters of the students were tested with a spirometer during their ordinary training work in a prosthodontics laboratory, before contact with MMA and immediately after it. The lung function test was performed using a standard protocol. The students were asked not to use any perfume or aromatic overlaps for a period of 24 h before starting the tests. Results. The researchers noted a statistically significant decrease (p ≤ 0.05) in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow (PEF), forced expiratory flow at 25-75% of the pulmonary volume (FEF25-75), and forced expiratory flow at 25% (FEF25) and 50% (FEF50) of the pulmonary volume in smokers and non-smokers by comparing the pre-and post-work tests. Conclusions. Acute inhalation of MMA vapor induced a moderate restriction of pulmonary function in dental students, both smokers and non-smokers, during their routine prosthodontics laboratory training work. No differences in the results of the pulmonary function tests between smokers and non-smokers were observed.

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Effects of methyl methacrylate monomer vapors on respiration and circulation in unanesthetized rats

Cited by 8 publications

References 13 publications

The Effects of Methyl Methacrylate on Nasal Cavity, Lung, and Antioxidant System (An Experimental Inhalation Study)

The Effects of Methyl Methacrylate on Nasal Cavity, Lung, and Antioxidant System (An Experimental Inhalation Study)

Knowledge, attitude, and practice of digital dentures among dentists

Effect of acute methyl methacrylate vapor inhalation on smokers’ and non-smokers’ respiratory function in a sample of male dentistry students

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