Effects of Moringa oleifera on oxidative stress, apoptotic and inflammatory biomarkers in streptozotocin-induced diabetic animal model

Oguntibeju, Oluwafemi Omoniyi; Aboua, Yapo Guillaume; Omodanisi, Elizabeth I.

doi:10.1016/j.sajb.2019.08.039

Cited by 43 publications

(17 citation statements)

References 78 publications

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“…The MOE group received 250 mg/kg MOE by oral gavage based on the study of Oguntibeju et al. (2020). The PbAc group received 20 mg/kg PbAc via i.p.…”

Section: Materials and Techniquesmentioning

confidence: 99%

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Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

Al-Qahtani

Albasher

2020

J. Food Biochem.

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Lead (Pb), a toxic heavy metal, is often used in the production and recycling of batteries, petrol, and paints (AL-Megrin, Alkhuriji, et al., 2020; AL-Megrin, Soliman, et al., 2020). According to Obeng-Gyasi et al. (2018) and Qi et al. (2019), exposure to Pb affects the central nervous system and the hematopoietic, hepatic, excretory, and reproductive systems, leading to serious dysfunction. There are few reports on the safe levels of Pb. However, Mason et al. (2014) note that exposure to even low levels of Pb (5 μg/dl) may lead to reduced

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“…The MOE group received 250 mg/kg MOE by oral gavage based on the study of Oguntibeju et al. (2020). The PbAc group received 20 mg/kg PbAc via i.p.…”

Section: Materials and Techniquesmentioning

confidence: 99%

“…The control group was given normal saline solution orally, then injected with saline solution intraperitoneally (i.p.). The MOE group received 250 mg/kg MOE by oral gavage based on the study of Oguntibeju et al (2020). The PbAc group received 20 mg/kg PbAc via i.p.…”

Section: Animals and Experimental Proceduresmentioning

confidence: 99%

Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

Al-Qahtani

Albasher

2020

J. Food Biochem.

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“…5 Several defense mechanisms have also been shown to contribute to Streptozotocin-induced (STZinduced) oxidative damage, among which are antioxidants that act as free-radical scavengers. [6][7][8][9] At the present time, the popularity of herbal drugs is gaining momentum in treating diabetes along with the complications associated with it. In developing strategies for alleviation of oxidative damage in diabetic patients, natural antioxidants have come to the fore in the current studies conducted on diabetes.…”

Section: Introductionmentioning

confidence: 99%

Streptozotocin‐Induced Oxidative Stress in Rats: The Protective Role of Olive Leaf Extract

Ağgül

Gür

Gülaboğlu

2020

Bulletin Korean Chem Soc

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This paper investigates the antidiabetic and antioxidant effects of olive leaf extract (OLE) prepared in ethanol upon Streptozotocin (STZ)-induced diabetic rats. The rats were divided into five groups (control, OLE, 40 mg/kg STZ, 0.25 g/kg OLE + STZ, and 0.5 g/kg OLE + STZ). The blood of rats was taken for determination of glucose levels besides oxidative activities (superoxide dismutase-SOD, glutathione peroxidase-GPx, glutathione-S transferase-GST activities, and malondialdehyde-MDA) and biochemical parameters (alanine transaminase-ALT, aspartate transaminase-AST, and alkaline phosphatase-ALP). While ALP, AST, ALT, and MDA levels showed an increase, SOD, GPx, and GST levels decreased in Group STZ compared to Control Group. When compared to the group given only STZ, OLE played a significant role in decreasing MDA, ALT, AST, and ALP levels, apart from increasing GPx, and GST following treatment of diabetic rats. As a result, the in vivo data obtained have shown that the OLE has an antidiabetic effect thanks to restricting oxidative stress and reinforcing antioxidant activities.

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“…It also upregulates Bcl2 level and downregulates NFKβ level proving its anti-apoptotic activity 8 . Antiproliferative activity of hexane fraction of crude ethanolic seed extract Moringa oleifera was investigated against breast cancer cell (MCF7).…”

Section: Pharmacological Potentials Of Moringa Oleiferamentioning

confidence: 99%

“…Among several species, Moringa oleifera is a current interest of research as it possesses tremendous potentials 6 . This plant is generally utilized as a dietary spice and contains significant pharmacological activity like anti-diabetic 7 hepatoprotective, anti-inflammatory 8 anti-asthmatic 9 anti-cancer 10 Antibacterial 11 antifungal activities 12 anti-oxidant 13 cardiovascular 14 CNS activity, anti-ulcer, wound healing 35 anti-fertility 15 antiallergic activity, antipyretic activity and antiepileptic 16 . In the Philippines, it is known as 'mother's best friend' due to its usage to increment lady's milk creation and is once in a while recommended for iron deficiency or anemia 58 .…”

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confidence: 99%

Untitled

2020

IJPSR

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Moringa oleifera, a miracle plant, is praised for beneficial health nutrients and has potential cholesterol-lowering activity. Almost all the parts of the Moringa oleifera plant have potential bioactivity. The main active constituents of Moringa oleifera are flavonoids, alkaloids, phenols, vitamins, minerals, proteins, glycosides, Glucosinolates and Isothiocyanates, terpenes, saponins, tannins, and many more. The Moringa oleifera has potent activity towards various ailments such ascancer, diabetes, inflammatory, antibacterial properties, cardiovascular diseases, and many more. Hyperlipidemia is referring to the increase in the level of lipid in plasma, and that leads to cardiovascular diseases. Antihyperlipidemic activity of Moringa oleifera is reported to be due to phytochemicals such as flavonoids, phytosterols, and phenols. This review mainly focuses on the pharmacological role of Moringa oleifera in the treatment of hyperlipidemia. The present article also describes the bioactive constituents of Moringa oleifera and its therapeutic activity. INTRODUCTION: Hyperlipidemia an abnormal elevation of excess fatty substances called lipids, largely cholesterol and triglycerides, in the blood and common risk factor for cardiovascular diseases as a person with hyperlipidemia is about twice probable to develop coronary heart disorders 1, 2. The major causes are obesity, genetic diseases, dietary diseases, diabetes, etc. High lipid concentration elevates atherogenesis and leads to hyperlipidemia 3. Apart from this, there are other types of hyperlipidemia, which include Hypertriglyceridemia and blended hyperlipidemia, in which both cholesterol, fatty substance (lipids), and triglycerides levels are raised.

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Effects of Moringa oleifera on oxidative stress, apoptotic and inflammatory biomarkers in streptozotocin-induced diabetic animal model

Cited by 43 publications

References 78 publications

Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

Streptozotocin‐Induced Oxidative Stress in Rats: The Protective Role of Olive Leaf Extract

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