Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

Abstract

Lead (Pb), a toxic heavy metal, is often used in the production and recycling of batteries, petrol, and paints (AL-Megrin, Alkhuriji, et al., 2020; AL-Megrin, Soliman, et al., 2020). According to Obeng-Gyasi et al. (2018) and Qi et al. (2019), exposure to Pb affects the central nervous system and the hematopoietic, hepatic, excretory, and reproductive systems, leading to serious dysfunction. There are few reports on the safe levels of Pb. However, Mason et al. (2014) note that exposure to even low levels of Pb (5 μg/dl) may lead to reduced

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

“…Hence, the methanol leaf extract improved the homocysteine and AF64A induced oxidative stress, cognitive impairments and Aβ pathology in rats, being a promising candidate for Alzheimer’s disease [ 34 , 35 ]. Moreover, the methanol extract of moringa leaves (250 mg/kg, 300 mg/kg) attenuated lead and aluminum-induced cerebral damage in rats by reducing oxidative stress, inflammation and apoptosis and by improving neurohistopathology [ 36 , 37 ]. Compounds identified as potential neuroprotective agents for moringa include isothiocyanate isolated from seeds [ 38 ].…”

Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosisviathe miR-22-3p/SIRT1 axis

“…40 The decreases in the activities of both enzymes were likely because the overproduction of ROS might deplete the activities of SOD and GPx, and Pb exhibited a high affinity to the thiol groups in the antioxidant enzymes or antioxidative molecules, causing decreases in antioxidant enzymes such as SOD. 18 In this study, the APE administration significantly attenuated the Pb(Ac) 2 -induced oxidative stress-related changes (based on the comparisons between the Pb(Ac) 2 + APE group and Pb(Ac) 2 alone group). In a previous study, 41 the protective effects of the APE against the aluminum-induced cognitive impairment in rats were also related to the antioxidant activity of the APE.…”

“…17 Some plant extracts and polyphenol compounds with strong antioxidant activities were found capable of alleviating Pb-induced neurotoxicity. 18 These findings indicate the potential of naturally occurring phenolic compounds counteracting Pb-induced cognitive dysregulation. Apples are one of the most popular fruits worldwide and contain abundant phenolic compounds including proanthocyanidins, chlorogenic acid, quercetin, phloretin, phloridzin, epicatechin and catechin.…”

“…53 Oxidative stress, inflammation and neuronal apoptosis are implicated in the evolution of Pb-induced cognitive dysfunction. 18 Upon a Pb injury, an excessive activation of microglia triggers the synthesis of multiple proinflammatory cytokines, chemokines and neurotoxic factors. 54 Oxidative stress also directly promotes inflammatory cytokine expression, thereby amplifying the inflammatory processes.…”

Lactobacillus plantarum FNCC 0137 fermented red Moringa oleifera exhibits protective effects in mice challenged with Salmonella typhi via TLR3/TLR4 inhibition and down-regulation of proinflammatory cytokines

“…Further, probiotic use could stimulate the anti-inflammatory cytokine expression, followed by reducing proinflammatory cytokines [ 57 ]. The anti-inflammatory properties of MOL have been reported to decline NFκB and proinflammatory cytokines expression in several animal models of inflammation [ 58 , 59 ]. Based on our findings, we assumed that both NRMOL and FRMOL might be useful to also treat other inflammatory diseases through the downregulation of inflammatory cytokines in the TLRs signaling pathway.…”