Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers

Protective effect of sulfurous water in peripheral blood mononuclear cells of Alzheimer's disease patients

“…After performing the treatment our results were similar to those obtained by previous works exposing human PBMC to the same concentration of 100 μM HP [5,18,37,45]. Moreover, when MTT assay was performed, a remarkable decrease in cell viability was observed confirming that the produced oxidative DNA damage and OS led to a diminished cell viability not only in AD population but also in controls.…”

Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement

“…In contrast, reductions to C-reactive protein have been demonstrated following a longer period of 6 months multivitamin supplementation in subjects aged 30-70 years. Prior intervention trials have also shown that 4 weeks multivitamin treatment reduced levels of DNA oxidative stress in elderly subjects (Ribeiro et al 2007) and 12 weeks supplementation with combined vitamins C and E attenuated urinary isoprostanes in individuals at risk of cognitive decline ). However, other intervention studies have indicated that benefits may be restricted to individuals with low baseline antioxidant status (Carty et al 2000) or elevated oxidative stress (Block et al 2008).…”

“…In studies of cardiovascular parameters, multivitamins have been demonstrated to reduce platelet activation (Salonen et al 1991;Arnaud et al 2007), concentrations of the C-reactive protein marker of inflammation , and to increase HDL cholesterol (Shargorodsky et al 2010). Other trials have identified reductions to markers of DNA damage in lymphocytes (Ribeiro et al 2007) and oxidative stress in red blood cells (Cheng et al 2001). Improvements to biochemical cardiovascular markers, inflammation and oxidative stress represent potential mechanisms via which cognitive enhancements may occur.…”

Prevention of Mutation, Cancer, and Other Age‐Associated Diseases by Optimizing Micronutrient Intake

“…Many of these and other moderate micronutrient deficiencies, when studied epidemiologically, are associated with cancer [24, 69, 83–93]. A number of human intervention studies with micronutrients report a decrease in DNA damage or cancer [52, 94–96] though more studies are needed to reach a definitive conclusion. The limitations of experimental approaches available for demonstrating a causal relation between micronutrient deficiency and cancer have been pointed out [97, 98]; a critical analysis of this large literature is not attempted here.…”