Effects of neuromuscular block on systemic and cerebral hemodynamics and bispectral index during moderate or deep sedation in critically ill patients

Abstract

Neuromuscular block altered the BIS score in moderately sedated patients but not in deeply sedated patients although cerebral hemodynamics was not affected by neuromuscular block during either moderate or deep sedation. Muscular relaxant also enhanced cardiovascular stability with moderate sedation. These results suggest that level of consciousness may be decreased by neuromuscular block during moderate sedation but not affected during deep sedation.

Bispectral monitoring in dogs subjected to ovariohysterectomy and anesthetized with halothane, isoflurane or sevoflurane

“…The electromyographic signals are distinguished by waves of 30–300 Hz, with a possible overlapping of the frequency spectrum, since the BIS monitor only filters frequencies above 70 Hz and the artifacts produced by myoelectrical activity can alter the value of BIS (Johansen & Sebel 2000; Dahaba et al. 2004; Inoue et al. 2006).…”

The EEG signal: a window on the cortical brain activity

“…These are rapid oscillations 20–80 Hz and can influence the calculations in a portion of automated EEG analysis, with their upper limit of 30–40 Hz. Supporting this is the observation that in the adult under light propofol anesthesia, the BIS value diminishes with use of muscle relaxants (16). In children under light levels of propofol anesthesia, this effect may be seen, but not under sevoflurane anesthesia (Figure 6) (17).…”

Cerebral blood flow monitoring using a novel laser Doppler flowmeter in asphyxiated infants

“…Arterial carbon dioxide tension (PaCO 2 ) was maintained at normocapnea (range 35–50 mmHg). There was no significant difference in the period of intubation between group A (7.0 ± 4.5 days) and group B (10.0 ± 2.9 days): other supportive treatments that might affect CBF, 7–9 such as muscle relaxants, catecholamines, and therapeutic hypothermia were performed in some infants in both groups. The number of subjects receiving these treatments was equally distributed in both groups: administration of sedatives, group A, n = 6, group B, n = 5; administration of muscular relaxants, group A, n = 2, group B, n = 2; administration of catecholamines, group A, n = 4, group B, n = 4; therapeutic hypothermia, group A, n = 5, group B, n = 3.…”