Effects of nicotine on two types of motor activity in rats

Bryson, Rebecca; Biner, Paul M.; McNair, Eileen; Bergondy, Maureen L.; Abrams, Orin R.

doi:10.1007/bf00429211

Cited by 31 publications

(15 citation statements)

References 10 publications

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“…Voluntary exercise (and wheel running, its homologous in rodents) is considered a form of reinforcement (Garland et al, 2011). Nicotine markedly increases wheel running in rats habituated to the cage for several hours postinjection (Bryson, Biner, McNair, Bergondy, & Abrams, 1981;Gillman et al, 2008; but see Kuribara, Shinoda, & Uchihashi, 1995 for different effects in mice). When nicotine is administered chronically at fixed times of the day, increased wheel running is observed in the preinjection phase and persists for at least two days after cessation of the treatment (Gillman et al, 2008).…”

Section: Nicotine Effects On Central Circuits Of the Reward Systemmentioning

confidence: 99%

Nicotinic Regulation of Energy Homeostasis

Zoli

Picciotto

2012

Nicotine & Tobacco Research

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Introduction: The ability of nicotine, the primary psychoactive substance in tobacco smoke, to regulate appetite and body weight is one of the factors cited by smokers that prevents them from quitting and is the primary reason for smoking initiation in teenage girls. The regulation of feeding and metabolism by nicotine is complex, and recent studies have begun to identify nicotinic acetylcholine receptor (nAChR) subtypes and circuits or cell types involved in this regulation.

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Section: Nicotine Effects On Central Circuits Of the Reward Systemmentioning

confidence: 99%

Nicotinic Regulation of Energy Homeostasis

Zoli

Picciotto

2012

Nicotine & Tobacco Research

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“…The effects of nicotine on locomotor activity depend critically on the behavioural measure used (Bryson et al, 1981). In our previous studies (Clarke & Kumar, 1983a,b), we investigated only gross horizontal locomotion.…”

Section: Introductionmentioning

confidence: 99%

Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion‐blocking drug chlorisondamine

Clarke

1984

British J Pharmacology

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1 Drug-naive rats were tested for horizontal and vertical activity in photocell cages, for up to 80 min starting immediately after a subcutaneous injection of (-)-nicotine bitartrate or 0.9% w/v NaCl solution (saline). Nicotine (0.1 to 0.4 mg kg' base) depressed vertical activity and induced ataxia in the first 20 min, but increased both horizontal and vertical activity later in the session; these actions were dose-dependent. A single intraventricular (i.v.t.) injection of chlorisondamine Cl (2 fig base), a quaternary ganglion-blocking drug, given one to two weeks before testing, blocked the ataxic and stimulant actions of nicotine. 2 The antagonistic actions of chlorisondamine (0.2, 1.0, 5.0 jig i.v.t., single administration) were shown to be dose-dependent. The stimulant actions of nicotine were blocked in a dose-dependent way for the duration of the experiment (5 weeks); nicotine's depressant actions were completely blocked at two weeks but not at five weeks.3 A ganglion-blocking dose of chlorisondamine (0.1 mg kg-'), given subcutaneously (s.c.), failed to reduce the behavioural actions of nicotine, whereas a much higher systemic dose (10 mg kg-l s.c.) was effective for at least five weeks. 4 Chlorisondamine failed to alter the behavioural effects of (+)-amphetamine or apomorphine, while blocking those of nicotine. 5 It is concluded that chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way.

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“…However, the body weight results showed that NIC suppressed weight throughout the entire NIC administration phase. That body weight remained suppressed while food intake showed recovery may be due to NIC's ability to increase energy expenditure (Bryson et al 1981;Bowen et al 1986;Winders and Grunberg 1990).…”

Section: Discussionmentioning

confidence: 91%