Effects of Obesity on Respiratory Function

Ray, C S; Sue, Darryl Y.; Bray, George A.; Hansen, James E.; Wasserman, Karlman

doi:10.1164/arrd.1983.128.3.501

Cited by 501 publications

(352 citation statements)

References 23 publications

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“…[26][27][28] A consistent negative association between WC and pulmonary function has recently been demonstrated in normal weight, overweight and obese subjects, suggesting that FM stored in the abdominal cavity, particularly visceral fat, most likely directly impedes the descent of the diaphragm leading to primarily restrictive respiration impairment. 28 Among obese subjects, there is evidence of peripheral airway obstruction, as manifested by air trapping and reduced maximum expiratory flow rates.…”

Section: Discussionmentioning

confidence: 71%

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

et al. 2008

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Objective: To evaluate over a 7-year follow-up period the relationships between changes in body composition, fat distribution and pulmonary function in a sample of elderly men and women. Design: Longitudinal clinical study. Subjects: A total of 47 women and 30 men aged 71.6±2.3 and 71.7±2.2 years, respectively, at baseline with body mass index (BMI) values of 24.96 ± 3.28 and 27.04 ± 3.35 kg m À2 were followed for 7 years. Measurements: Body weight, waist circumference, sagittal abdominal diameter (SAD), fat-free mass (FFM) and fat mass as measured by dual energy X-ray absorptiometry (DXA) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) by spirometry were evaluated at baseline and after a 7-year mean follow-up. Results: In women as in men there were no significant changes in weight, SAD and BMI. A significant decrease in height and FFM was observed in both women and men. Height-adjusted FEV1 and FVC decreased significantly in women and men over the 7-year follow-up. Changes in SAD were the most powerful predictors of 7-year follow-up of FEV1 and FVC after taking into account, respectively, baseline FEV1 and FVC. Linear regression analysis, performed by using 7-year follow-up lung function variables as dependent variables and changes in body composition variables as independent variables, showed that 1 cm SAD increase predicted a decrease in FEV1 and FVC of 31 and 46 ml, respectively, and 1 kg FFM decrease predicted a decrease in FVC of 38 ml. After subdividing our study population into four categories of change in FFM and SAD, patients with decreased FFM and increased SAD showed the highest probability of having a worsening in FEV1 and FVC. Conclusion: Increase in abdominal fat and FFM decline are significant predictors of lung function decline in the elderly. Old subjects developing both abdominal fat gain and FFM loss show the highest probability of developing worsening in lung function.

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Section: Discussionmentioning

confidence: 71%

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

et al. 2008

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“…This reduction does not represent an actual pulmonary restriction, but rather a restrictive behavior which usually tends to improve after weight loss as shown by the mean postoperative value of 3.07 l compared to the preoperative value of value of 2.60 l. Other studies have also reported a similar improvement of FRC over a six month period after the Fobi-Capella operation 6,9,10 .…”

Section: Correlation Between Percent Loss Of Weight Excess and Pulmonmentioning

confidence: 83%

“…Many literature reports emphasize the fact that morbidly obese patients have reduced expiratory reserve volume (ERV) and reduced al functional residual capacity (FRC), as well as restrictive respiratory behavior in many cases 10,11 . In severely obese patients, ventilatory normality is reestablished after weight loss as a consequence of increased FRC, residual volume (RV), total lung capacity (TLC), and ERV.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery

Xavier¹,

Ceneviva²,

Filho³

et al. 2010

Acta Cir. Bras.

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Purpose: To investigate the body weight, pulmonary function and quality of life of twenty patients with morbid obesity six months after the Fobi-Capella operation. Methods: Patients were evaluated before and six months after surgery. The patients were mainly female (75%), the average age was 40.5 ± 10.27 years; average weight 110.11 kg ± 21.77 and average body mass index (BMI) 39.93 ± 7.13 kg/m 2 in the postoperative evaluation. Pulmonary function was assessed by spirometry using a Pulmonet/Godart NV Bilt Vetr Hotland spirometer and quality of life was assessed by applying the Moorehead-Ardelt questionnaire. The pre-and postoperative spirometry values were compared by the paired Student t test and the correlation between weight loss and pulmonary function was determined by linear regression, with the level of significance set at p < 0.05. Results: The spirometry variables Respiratory Frequency (RF), Expiratory Reserve Volume (ERV) and Functional Residual Capacity (FRC) differed significantly between the pre-and postoperative periods, whereas Residual Volume (RV), Vital Capacity (VC), Total Lung Capacity (TLC), FEF (Forced Expiratory Flow between 25 and 75% FVC) and FEV1/FVC% (Forced Expiratory Volume in the 1 st second/ Forced Vital Capacity ratio) did not differ between periods. Only one patient reported worsening of quality of life. There was a positive correlation between weight loss and ERV (p=0.0117, r=0.5514), but no correlations were observed for the other variables. Conclusions: There was a significant weight loss and an improvement of pulmonary function as seen by respiratory frequency, reduction and increased expiratory reserve volume and functional residual capacity. The quality of life of the patients also improved after the Fobi-Capella operation. Key words: Obesity, Morbid. Respiratory Function Tests. Quality of Life. Bariatric Surgery. RESUMOObjetivo: Investigar a evolução do peso corpóreo, da função pulmonar e da qualidade de vida de 20 pacientes obesos mórbidos seis meses após operação de Fobi-Capella. Métodos: Os pacientes foram avaliados antes e seis meses após a cirurgia e o sexo feminino predominou em 75%, com média de idade de 40,5 anos ± 10, 27, média de peso de 110,11 kg ± 21,77 e IMC de 39,93 kg/m 2 ± 7,13. Para a avaliação da função pulmonar foi realizada espirometria por meio do espirômetro Pulmonet Godart NV Bilt Vetr Holland, e para a qualidade de vida foi aplicado o questionário de Moorehead-Ardelt. As comparações entre os valores espirométricos do pré e do pós-operatório foram realizadas pelo teste t de Student para amostras pareadas, e para a correlação entre a perda de peso e função pulmonar utilizou-se análise de regressão linear simples, adotando-se p < 0,05 para todos os resultados. Resultados: As variáveis espirométricas Freqüência Respiratória (FR), Volume de Reserva Expiratório (VRE) e Capacidade Residual Funcional (CRF) apresentaram, aos seis meses após a operação, diferença estatisticamente significativa com os valores pré-operatórios, porém, não houve diferença ...

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“…Additionally, increases in total body mass are associated with a decline in ERV, and therefore FRC; consistent with the notion that this effect seems to be evident only in severely obese subjects, we were not able to find a negative effect of weight on the LV of males (Table 5). On the other hand, in females, weight was positively related to IC and negatively to RV/TLC (Table 5): the first effect could represent the known positive relation between body mass and PImax (since the inspiratory capacity is closely related to respiratory muscle strength) and the latter effect, a reduction in ERV due to a more central deposition of fat in females (39).…”

Section: Discussionmentioning

confidence: 99%

Reference values for lung function tests: I. Static volumes

Neder

Andreoni

Castelo-Filho

et al. 1999

Braz J Med Biol Res

256

175

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Static lung volume (LV) measurements have a number of clinical and research applications; however, no previous studies have provided reference values for such tests using a healthy sample of the adult Brazilian population. With this as our main purpose, we prospectively evaluated 100 non-smoking subjects (50 males and 50 females), 20 to 80 years old, randomly selected from more than 8,000 individuals. Gender-specific linear prediction equations were developed by multiple regression analysis with total lung capacity (TLC), functional residual capacity (FRC), residual volume (RV), RV/TLC ratio and inspiratory capacity (IC) as dependent variables, and with age, height, weight, lean body mass and indexes of physical fitness as independent ones. Simpler demographic and anthropometric variables were as useful as more complex measurements in predicting LV values, independent of gender and age (R 2 values ranging from 0.49 to 0.78, P<0.001). Interestingly, prediction equations from North American and European studies overestimated the LV at low volumes and underestimated them at high volumes (P<0.05). Our results, therefore, provide a more appropriate frame of reference to evaluate the normalcy of static lung volume values in Brazilian males and females aged 20 to 80 years.

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Effects of Obesity on Respiratory Function

Cited by 501 publications

References 23 publications

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery

Reference values for lung function tests: I. Static volumes

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