Effects of occupational lead exposure on testosterone secretion

Tutkun, Lütfiye; İritaş, Servet Birgin; İlter, Hüseyin; Gündüzöz, Meşide; Deniz, Serdar

doi:10.5455/medscience.2018.07.8880

Cited by 6 publications

(6 citation statements)

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“…These results were similar with other studies (19,37). Such changes due to oxidative stress-induced by lead attributed to protein interaction mechanisms and induced programing cell death associated with decline in testosterone hormone (38) as well as, supposed that cytoskeleton dysfunction might inhibit the synthesis and/or transport LH receptors, these results correlated with (6). Supplementation of both lead and ALA for 56 day caused rrearrangement of histopathological changes of the testes near to normal against lead acetate and restored their activity.…”

Section: Discussionsupporting

confidence: 90%

“…Lead has been found to cause a significant decrease in testosterone hormone concentration through the experimental periods in T1 group, this result was consistent with that recorded by Wahab et al, (25). A decreased in testosterone could be resulted by the effect of lead acetate on the axial of hypophysis-pituitary-testes and/or by decreasing in the activity of testicular steroidogenic enzymes, such as 3betahydroxysteroid dehydrogenase (3β-HSD), 17betahydroxy dehydrogenase (17β-HSD) resulted to Sertoli and Leydig cells insufficiency causes testicular damage and decrease in testosterone synthesis (6,8). Moreover, we have observed an increase in FSH concentration in lead acetate treated group.…”

Section: Discussionsupporting

confidence: 89%

“…One major manifestation of accumulation of lead in the cells is attributed to induce oxidative stress that causing loss the integrity of the cell membrane, mitochondrial dysfunction, deoxyribinucleaic acid (DNA) damage, apoptosis and antioxidant defense systems of cells (3) via increased production of reactive oxygen species (ROS) which may be contributed to an increase in lipid peroxidation (LPO) level (4), moreover, the disorder of mitochondrial enzymes with a dropped antioxidants level by lead toxicity in spermatozoa resulting in alterations in sperm motility, acrosomal morphology, semen quality and increased tail anomalies (5). It has been observed that lead causes a decline in fertility via decreasing in the level of testosterone, moreover dropping in testosterone production in rats was reported as well (6) after exposure to lead. Many potential adverse effects on the male reproductive system were being caused by exposure to lead including oligozoospermia, asthenozoospermia, libido reduction, sperm DNA damage, prostate gland abnormal function and serum testosterone alteration (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Role of alpha lipoic acid in protecting testes of adult rats from lead toxicity

Al-Okaily¹,

Murad²

2021

IJVS

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The current study was conducted to investigate the role of alpha lipoic acid (ALA) against testicular toxicity-induced by lead acetate (PbAc) in rats. Four groups of adult Wistar albino rats (8 for each) were intubated daily for 56 days as follows; control (C)received dislled water; lead acetate at dose of 5mg/kg b.w (T1); ALA at dose of 60mg/kg b.w (T2) and and group T3 received both of PbAc + ALA at the same doses of above. Blood samples were collected at 0, 28 and 56 day of the experiment, then the sera were collected for determination of testosterone (T) and follicular stimulating hormone (FSH). At the end of the experiment, body weight, testes weight and epididymal sperm parameters was studied. Furthermore, histo-morphometric and histopathological study changes were examined. The results revealed a significant decrease in testes weight to body weight ratio, serum testosterone, sperm concentration and motility, diameters of seminiferous tubules, height of seminiferous epithelia and number of Leydig cells, moreover the results showed a significant increase in serum FSH, dead sperm and abnormal sperm morphology in group T1 when compared with the other groups. Comparing to lead acetate treated rats, group T3 showed an improvement at the level of the studied parameters, accompanied with mild congestion in the interstitial tissue with a marked developing proliferation of spermatogenic cells, as well as presence of mature spermatozoa in the seminiferous tubules. In conclusion, subchronic exposure of rats to lead acetate showed an amelioration of all reproductive parameters near to normal values due to the antioxidant effects of ALA and the histological changes of the testes confirmed such change in serum parameters and the beneficial role of ALA.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Role of alpha lipoic acid in protecting testes of adult rats from lead toxicity

Al-Okaily¹,

Murad²

2021

IJVS

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“…The control group was 63 healthy office workers without exposure to heavy metals. The results of this study showed that there were significant differences in the levels of total testosterone (TT), free testosterone (FT), prolactin (PRL), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) in the study group and control group (Tutkun et al, 2018).…”

Section: Resultsmentioning

confidence: 87%

Effect of Giving Jamblang (Syzygium cumini) Leaf Extract on Testosterone Serum Level and Concentration of Spermatozoa in Male Rats Intoxicated with Lead Acetate

Wardiyah,

Rita,

2024

Int J Res Rev

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Lead is a source of free radicals in the environment. Lead accumulation in the blood generates increasing reactive oxygen species (ROS) in the body and various health problems, including male infertility. One effort that can be made to prevent this problem is to use antioxidants from natural sources such as jamblang (Syzygium cumini) leaf extract. This study is experimental with a randomised posttest-only control group design method. The object of this study was 30 white rats (Rattus norvegicus strain Wistar) which were divided into five groups (K-, K+, P1, P2, and P3). Lead acetate was given as much as 40 mg/kgBW in groups K+, P1, P2, P3 orally for 30 days. Jamblang (Syzygium cumini) leaf extract was given 50 mg/kgBW in the P1 group, 150 mg/kgBW in the P2 group, and 300 mg/kgBW in the P3 group orally for 30 days. Testosterone levels were examined using blood serum taken through the retro-orbital vein and examined using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Spermatozoa were taken from the vas deferens and counted using the Neubauer counting chamber. The average level of testosterone serum was at K-2.47 ± 0.59 nmol/ml, K+ 2.23 ± 0.45 nmol/ml, P1 2.35 ± 0.65 nmol/ml, P2 2.56 ± 0 .73 nmol/ml, P3 1.96 ± 0.59 nmol/ml, there was no significant difference statistically (p > 0.05). The average concentration of spermatozoa at K-32.06 ± 2.66 million/ml, K+ 19.45 ± 8.07 million/ml, P1 27.05 ± 1.89 million/ml, P2 28.65 ± 1.10 million/ml, P3 27.11 ± 5.64 million/ml, statistically there was a significant difference (p < 0.05). There was no effect of giving jamblang (Syzygium cumini) leaf extract on testosterone serum levels and there was an effect of giving jamblang (Syzygium cumini) leaf extract on the concentration of spermatozoa of male Rattus norvegicus rats intoxicated with lead acetate. Keywords: lead acetate, jamblang leaf extract, testosterone, spermatozoa

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“…In the current study, lead treated group showed significant reduction in serum level of testosterone, LH and FSH as compared to control group, this was in agree with (31,32,33,34). Decrease serum testosterone may be due to direct toxic effect of Pb on leydig cells causing its apoptosis (35). Pb inhibits steroidogenic enzyme production in Leydig cells resulting in reduced testosterone secretion (36).…”

Section: Discussionmentioning

confidence: 99%

The Possible Protective Role of Crocin and Pumpkin Seed Oil against Lead-Induced Testicular Cytotoxicity in Adult Male Albino Rat.Hormonal, Histological and Immunohistochemical study.

Mousa

Allam²,

Mohamed³

2022

Benha Medical Journal

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Background: Lead (Pb) disturbs of oxidant/antioxidant balance in testicular cells causing oxidative stress. Crocin (Cr) and pumpkin seed oil (PSO) have antioxidant effects and neutralize free radicals. Aim: This study was performed to assess the cytotoxicity of lead on testis and the possible protective effect of Cr and PSO. Methods: Forty eight healthy male rats were divided into six groups as follows: Control group, Cr group: each rat was received Crocin (200 mg/kg) given intraperitonealy (ip) once daily for 4 weeks, PSO group: each rat was orally received PSO (1 ml/kg) daily for 4 weeks , Pb group: each rat was received lead acetate, (8 mg/kg) ip daily for 4 weeks, (Cr+ Pb) group: each rat was received (200 mg/kg) crocin ip with 8 mg/kg Pb ip for 4 weeks and (PSO+ Pb) group: each rat was received PSO (1 ml/kg) orally in addition to ip lead acetate (8 mg/kg) daily for 4 weeks. The testicular tissues have been processed for a light microscopic study. Results: In Pb -treated rats, levels of FSH, LH, and testosterone significantly decreased. Decrease thickness of spermatogenic layers, mispresentation, Vacuolations, degeneration of spermatogenic cells, wide interstitial spaces, Weak PCNA and androgen receptor immunoexpression were observed. Both Cr and PSO treatment resulted in reversing Pb effects on testis presented in improvement in hormonal levels and histological architecture of most of seminiferous tubules with increase PCNA and androgen receptor immunoexpressions. Conclusions: Cr and PSO may have ameliorative effects after lead acetate toxicity on rat testis.

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Effects of occupational lead exposure on testosterone secretion

Cited by 6 publications

References 0 publications

Role of alpha lipoic acid in protecting testes of adult rats from lead toxicity

Role of alpha lipoic acid in protecting testes of adult rats from lead toxicity

Effect of Giving Jamblang (Syzygium cumini) Leaf Extract on Testosterone Serum Level and Concentration of Spermatozoa in Male Rats Intoxicated with Lead Acetate

The Possible Protective Role of Crocin and Pumpkin Seed Oil against Lead-Induced Testicular Cytotoxicity in Adult Male Albino Rat.Hormonal, Histological and Immunohistochemical study.

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