Effects of oral contraception with ethinylestradiol and drospirenone on oxidative stress in women 18–35 years old

Groote, Donat De; d'HAUTERIVE, Sophie Perrier; Pintiaux, Axelle; Balteau, Bénédicte; Gerday, Colette; Claesen, Jürgen; Foidart, Jean‐Michel

doi:10.1016/j.contraception.2009.02.015

Cited by 40 publications

(33 citation statements)

References 60 publications

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“…The connection between OS and the E 2 and P4 levels is also confirmed by the previous observations, since we know that the levels of hydroperoxide in women taking birth control pills increase significantly [12,13]. This fact must clearly be confirmed through specific studies, but tends to discredit the hypothesis that exogenous estrogens have an antioxidant action [14,15].…”

Section: Discussionsupporting

confidence: 71%

Analysis of oxidative stress during the menstrual cycle

Cornelli

Belcaro

Cesarone

et al. 2013

Reprod Biol Endocrinol

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BackgroundFew data concerning the oxidative stress (OS) in plasma during the entire menstrual cycle of eumenorrheic women are available.MethodsOS was assessed in 20 healthy volunteers during the phase of the menstrual cycle by determining the plasmatic hydroperoxides levels (d-ROMs test). The assessment was performed every three days, starting from the first day (t1) up the end of the menstrual phase (t27). Concomitantly, the estrogen (E2) and progestin (P4) levels were determined at the same time intervals.ResultsFrom a base value (t1) of 284 +/− 38.0 CARR.U., which is essentially within the normal range (<300 Carratelli units or CARR.U.), the OS levels progressively increased to 378 +/− 115 CARR.U. at t15, and then slightly decreased over the subsequent time but with average values >300 CARR.U. Analysis of the E2 levels showed that the maximum OS values were noticed near the estrogen peak, while remaining above the base levels, and then decreased during the progestin phase until returning to normal at the end of the menstrual cycle.ConclusionsIt may concludes that the healthy women go into OS for 2/3 of the menstrual cycle.

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Section: Discussionsupporting

confidence: 71%

Analysis of oxidative stress during the menstrual cycle

Cornelli

Belcaro

Cesarone

et al. 2013

Reprod Biol Endocrinol

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“…A research conducted in 40-48 years old Belgian women found a signi cant increase of lipid peroxides in 209 OC-users compared to 119 non-users of contraception (22). A study comparing 32 OC-users with 30 non-OC-users found increased lipid peroxides (+176%, p<0.001) and oxidized LDLs (+145%, p<0.002) in the former group of women (20).…”

Section: Oxidative Stressmentioning

confidence: 97%

“…P450 cytochromes (CYPs) catabolizing exogenous hormones can cause increased ROS production (51) and, in turn, hyper-production of free radicals could provoke depletion of antioxidant defenses such as depletion of reduced glutathione (31,33). However, the role of estrogens and progestogens in OC induced oxidative stress is still debated (20,31,52). An in vitro study showed that beta-estradiol treatment of cells resulted cytotoxic through oxidative stress provoking signi cant increase in lipid peroxidation (53).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Presently, few studies assessed oxidative stress (17)(18)(19)(20)(21)(22) and low-grade in ammatory status (23)(24)(25)(26)(27)(28)(29) of OC-users pre-menopausal women, two conditions that are both implicated in several pathologies including CVDs and cancer. Rather surprisingly, however, no study ever examined the relationship between oxidative stress and low-grade in ammatory status in a sample of childbearing age women according to OC use.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Cauci

Francescato

Colannino

et al. 2020

Preprint

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Background Information concerning oxidative stress and low-grade inflammation in oral contraception users is scarce. We investigated relationships of oxidative stress and high-sensitivity C-reactive protein (hsCRP) in women by oral combined contraceptive (OC) use. Methods Caucasian Italian healthy non-obese women (n = 290; 100 OC-users; 190 non-OC-users; mean age 23.2 ± 4.7 years) were analyzed. Blood hydroperoxides, as oxidative stress biomarkers, were assessed by Free Oxygen Radical Test (FORT), and serum hsCRP was determined by routine methods. Results Oxidative stress levels were elevated (≥ 400 FORT Units) in 77.0% and 15.8% of OC-users and non-OC-users, respectively (odds ratio (OR) = 209, 95%CI = 60.9-715.4, p < 0.001); hsCRP levels ≥ 2.0 mg/L were found in 41.0% and 9.5% of OC-users and non-users, respectively (OR = 6.6, 95%CI 3.5–12.4, p < 0.001). Continuous hydroperoxides values in OC-users were 1.7-fold higher compared to non-users (median 472 versus 270 FORT Units, p < 0.001); OC-users had 3.7-fold higher hsCRP values compared to non-OC-users (median 1.31 versus 0.35 mg/L, p < 0.001). Hydroperoxides were strongly positively correlated to hsCRP in all women (rs=0.622, p < 0.001), in OC-users (rs=0.442, p < 0.001), and in non-OC-users (rs=0.426, p < 0.001). Women with hydroperoxides ≥ 400 FORT Units were 8 times as likely to have hsCRP ≥ 2 mg/L. In non-OC-users only, hydroperoxides values were positively correlated with weight and body mass index, but negatively correlated with red meat, fish and chocolate consumption. Conclusions Our cross-sectional observational study is the first finding a strong positive correlation of serum hydroperoxides with hsCRP, a marker of inflammation. Further research is needed to elucidate the potential role of these two biomarkers in OC-use side-effects, like thromboembolism.

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“…Estrogen can act as an antioxidant, and postmenopausal estrogen therapy has been reported to inhibit LDL oxidation 13,14) . In contrast, ethinyl estradiol present in combined oral contraceptive increases the plasma levels of free radicals and lipid peroxides 15,16) . Therefore, estrogen therapy has both pro-and antioxidant effects.…”

Section: Laboratory Analysismentioning

confidence: 99%