Effects of Oral Implant Surface Roughness on Bacterial Biofilm Formation and Treatment Efficacy

Lin, Hai; Liu, Yuelian; Wismeijer, Daniël; Deng, Dongsheng

doi:10.11607/jomi.3099

Cited by 43 publications

(16 citation statements)

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“…Additionally, a high level of protease activity may be a predictive factor for disease progression in peri-implantitis [38]. Rougher implant surfaces were found to cause reduced treatment efficacy, for example in the treatment of biofilm by chlorhexidine, but no influence on the amount of biofilm formation [54].…”

Section: Discussionmentioning

confidence: 99%

The effect of different surface topographies of titanium implants on bacterial biofilm: a systematic review

et al. 2019

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To compare the different surface topographies of titanium implants used in dentistry against the formation of bacterial biofilm. To identify relevant studies, the electronic databases PubMed, Science Direct and Springer Link were searched from inception until January 2019. A total of 38 studies were selected for the systematic review (n = 38). The most commonly used titanium surfaces were machined titanium (16.3%), sandblasted, large-grit, acid-etched titanium (10.9%), untreated or pure titanium (10.9%), polished titanium (9.8%), physically textured titanium (9.8%), acid-etched titanium (8.7%) and anodized titanium (5.4%). The majority of the studies (78.9%) found that surface topographies (with varying degrees of roughness) had a beneficial effect on the ability to allow low bacterial biofilm on the surfaces. A low roughness value (R a) of below 1 µm was found in 68% of these surfaces. Overall, no specific surface topography was found to be the ideal surface in allowing the least bacterial biofilm attachment. In this study, meta-analysis was not performed. This narrative systematic review provides a summary of the effects of surface topographies for future research and development of new dental implant surfaces and decontamination techniques.

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Section: Discussionmentioning

confidence: 99%

The effect of different surface topographies of titanium implants on bacterial biofilm: a systematic review

et al. 2019

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“…The comparison of this biofilm with previously published investigations evaluating biofilm formation on implant surfaces is difficult since these studies have used different samples such as disks, squares, nanotubes, etc, but not whole implant surfaces depicting the typical macro-structural design characteristics of threads, picks, and valleys (B. Guggenheim, Giertsen, Schupbach, & Shapiro, 2001;Lin et al, 2013;Narendrakumar et al, 2015;Park, Lee, Um, Chang, & Lee, 2014;Rath, Stumpp, & Stiesch, 2017;Roehling et al, 2017;Sanchez et al, 2014;Schmidlin et al, 2013;Thurnheer & Belibasakis, 2016;Violant et al, 2014). Similarly to the morphology shown on titanium and zirconium disks using the same multispecies bacterial inoculum (Sanchez et al, 2014), the resulting biofilms formed a continuous dense mass, covering the entire surface of the implant surface.…”

Section: Lower Limit Upper Limitmentioning

confidence: 99%

“…These complex surface topographies, which clearly enhance implant osseointegration, may also facilitate the development of complex biofilms and impair their cleanability (Ferreira Ribeiro et al, 2016;Di Giulio et al, 2016;Song, Koo, & Ren, 2015;Violant, Galofre, Nart, & Teles, 2014;Xing, Lyngstadaas, Ellingsen, Taxt-Lamolle, & Haugen, 2015). Previous in vitro research on implant surfaces has shown that roughness, surface free energy, wettability, and degree of sterilization may affect biofilm formation, bacterial three-dimensional distribution, and antimicrobial treatment efficacy (Al-Ahmad et al, 2010;Di Giulio et al, 2016;Lin, Liu, Wismeijer, Crielaard, & Deng, 2013;Schmidlin et al, 2013;Song et al, 2015;Yeo, Kim, Lim, & Han, 2012). These studies have used specimens, such as disks or slabs containing the studied surface (Aguayo, Donos, Spratt, & Bozec, 2015;de Avila et al, 2015;Di Giulio et al, 2016;Papavasileiou, Behr, Gosau, Gerlach, & Buergers, 2015;Pita et al, 2015;Ready et al, 2015), but these specimens lack the macro-structural and topographic characteristics of the dental implants used clinical practice.…”

mentioning

confidence: 99%

Topographic characterization of multispecies biofilms growing on dental implant surfaces: An in vitro model

Bermejo

Sanchez

Llama‐Palacios

et al. 2019

Clinical Oral Implants Res

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Objectives To describe the early biofilm formation over whole dental implants with its micro‐ and macrostructure, using an in vitro multispecies biofilm model. Material and methods Six bacterial strains (Streptococcus oralis, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans) were used to develop in vitro biofilms over whole titanium implants (growth times 12, 24, 48, 72, 96, and 120 hr). The morphology of biofilms was studied by confocal laser scanning microscopy and scanning electron microscopy, and the bacterial dynamics through quantitative polymerase chain reaction. As primary outcome variable, numbers of each species [colony‐forming units per milliliter (CFU/ml)] at different incubation times were compared using the one‐way analysis of variance and post hoc testing with Bonferroni's correction. Furthermore, implants were fixed in methacrylate stents to reproduce the clinical situation and biofilms were developed and analyzed by scanning electron microscopy. Results Bacteria colonized implants in a short period of time. Biofilms reached a mature state at 96 hr, exhibiting different ratios of live/dead cells depending on their location, being the peaks of the threads the areas harboring more live bacteria. The densities of each bacteria fluctuated in time, reaching its maximum at 96 hr. Even though the coefficients of variation were high, percentages were similar to those published previously using implant surface specimens, rather than whole implants. Conclusion Dental implants can be colonized by different bacterial species, developing into a mature and well‐structured biofilm, which depending on the location may exhibit different degree of bacterial vitality.

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“…It involved the nucleation and formation of bone-like crystals on a pretreated substratum by immersing it in a supersaturated solution of CaP under physiological conditions of temperature (37°C) and pH (7.4). The method has been improved and refined by several groups of researchers [ 9 , 11 , 18 - 20 ], and an extensive evaluation as well as pre-clinical studies have been made [ 21 , 22 ]. Recently a biomimetic calcium phosphate bone substitute has been developed based on biomimetic calcium phosphate coating [ 23 , 24 ].…”

Section: Biomimetic Calcium Phosphate Coatingsmentioning

confidence: 99%

A Review Paper on Biomimetic Calcium Phosphate Coatings

Lin¹,

Groot²,

Wang³

et al. 2015

TOBEJ

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Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.

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Effects of Oral Implant Surface Roughness on Bacterial Biofilm Formation and Treatment Efficacy

Abstract: A moderately roughened surface did not enhance biofilm formation but reduced treatment efficacy of the biofilms. This finding indicates that efforts should be directed toward optimizing implant surface properties for effective antimicrobial treatment without compromising osseointegration.

Cited by 43 publications

References 0 publications

The effect of different surface topographies of titanium implants on bacterial biofilm: a systematic review

The effect of different surface topographies of titanium implants on bacterial biofilm: a systematic review

Topographic characterization of multispecies biofilms growing on dental implant surfaces: An in vitro model

A Review Paper on Biomimetic Calcium Phosphate Coatings

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