Effects of Oral Supplementation With Plant Superoxide Dismutase Extract on Selected Redox Parameters and an Inflammatory Marker in a 2,000-m Rowing-Ergometer Test

Abstract

The aim of this study was to investigate the effect of plant superoxide dismutase extract (GliSODin) supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers. The double-blinded study included 19 members of the Polish rowing team who were participating in a preparatory camp. Subjects were randomly assigned to the supplemented group (n = 10), who received 2 capsules (500 mg) of GliSODin extract once daily for 6 weeks, or the placebo group (n = 9). At the beginning and end of the study, subjects performed a 2,000-m maximum-effort test on a rowing ergometer. Blood samples were taken from the antecubital vein before each exercise test, 1 min after completing the test, and after a 24-hr restitution period. The following redox parameters were assessed in erythrocytes: superoxide dismutase (SOD) activity, glutathione peroxidase activity, and concentrations of thiobarbituric-acid-reactive substances. In addition, creatine kinase activity and total antioxidant capacity were measured in plasma samples, lactate levels were determined in capillary blood samples, and C-reactive protein and lactate dehydrogenase concentrations were measured in serum. After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group than the placebo group, and C-reactive protein was significantly (p = .00001) lower in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers but had no effect on oxidative damage induced by exhaustive exercise.

Alterations in Redox Homeostasis in the Elite Endurance Athlete

“…If there was any doubt over whether the athletes were elite, the authors of the articles were emailed for further clarification; in total 14 authors were emailed. The methodology of the 59 elite athlete articles were then reviewed in detail (step 5), and 33 articles were excluded from the final review because of one or more of the following: the authors did not state the training status of the subjects, or respond to requests for subject details (n = 4) [38,46,73,74]; the subjects were masters/former athletes (n = 3) [75][76][77], amateur or college level athletes (n = 3) [ [78][79][80], athletes, but not elite status (n = 4) [42,48,81,82] or navy recruits (n = 1) [83]; participants were elite, but under 18 years of age (n = 2) [84,85]; only one sampling point was included, compared with healthy control data (n = 1) [86]; less than half of the study population were elite (n = 2) [87,88]; there were insufficient measures of redox balance [89,90] (n = 2); the training volume was not indicative of elite cyclists at 90 km per week (n = 1) [91]; the studies were RCTs involving antioxidant supplementation in elite athletes (n = 10) [92][93][94][95][96][97][98][99][100][101]. In addition, the methodological qualities of the articles were checked using methodological quality assessment criteria for the observational articles to be included in the final analysis (step 6).…”

Polyphenol Supplementation: Benefits for Exercise Performance or Oxidative Stress?

“…Superoxide dismutase was extracted from melons and coupled with a biodegradable biopolymer, in order to maintain the antioxidant enzyme activity despite oral intake. It was administered twice daily for 6 weeks, also during a training camp [58]. The activity of this enzyme increased in red cells, but the major physiological influence was not on oxidative stress but on inflammation.…”

Therapeutic value of oral supplementation with melon superoxide dismutase and wheat gliadin combination

“…Reports exist evaluating the effect of SOD-gliadin supplementation on intensive physical exercise. A clinical trial was performed during which volunteer professional athletes were subjected to daily treatment with SOD-gliadin (500 mg) or placebo for 6 wk [39]. In this study, blood samples were drawn from the athletes after a 2000-m rowing exercise test.…”