Effects of orally administered spinosad (Comfortis®) in dogs on adult and immature stages of the cat flea (Ctenocephalides felis)

Blagburn, Byron L.; Young, D. R.; Moran, C.; Meyer, Jürgen; Leigh-Heffron, Anna; Paarlberg, Tandy; Zimmermann, Alan G.; Mowrey, Daniel H; Wiseman, Scott; Snyder, Daniel E.

doi:10.1016/j.vetpar.2009.11.023

Cited by 43 publications

(34 citation statements)

References 10 publications

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“…selamectin). Recently, oral formulations appeared on the market, based on either nitenpyram [21], spinosad [3, 23, 26], afoxolaner [27] or fluralaner [22]. They provide a fast curative efficacy on existing flea infestation.…”

Section: Discussionmentioning

confidence: 99%

Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

et al. 2014

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The speed of efficacy of afoxolaner (NexGard®) against Ctenocephalides felis fleas was evaluated in two studies. Study A assessed the efficacy against existing fleas whereas study B assessed the efficacy against new infesting fleas. In study A, 12 dogs were allocated to the untreated group and 20 dogs to the treated group. All dogs were infested by 100 fleas each at Day −1, treated at Day 0 and flea combed at 2 h or at 6 h post treatment. In study B, 6 dogs were allocated to the untreated group and 10 to the treated group. They were infested with 100 fleas each on Days 2, 7, 14, 21 and 28. Fleas were removed and counted at 6 h post-infestation. Immediate and persistent efficacies were evaluated by counting fleas on the dogs. To evaluate induced mortality after exposure on dogs, fleas collected alive were placed in an insectarium for 24 h and assessed for viability. The immediate efficacy on dogs was significant at 6 h with 100%. The induced death of the fleas collected live from dogs 2 h after exposure was 99.7%. Concerning new infesting fleas, the observed efficacy at 6 h and the induced mortality were significantly different (p < 0.05) from the control at all time-points. At 6 h, the prophylactic efficacy was > 97% at Day 2 and Day 8 and > 90% at Day 14. The induced mortality after 6 h of exposure on dogs varied between 73.3% and 100% for the whole study.

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Section: Discussionmentioning

confidence: 99%

Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

et al. 2014

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“…As described by Chin et al, when treated animals move through infested environments newly emerged fleas infest the cat or dog and are rapidly killed before producing eggs and, over time, this has the effect of clearing the environmental infestation, thereby preventing reinfestation (Chin and others 2005, Dryden 2009). In this context, spinosad has proved highly effective in reducing flea egg output (Blagburn and others 2010) and in a simulated home environment study designed to assess prevention of establishment of a flea population where no live fleas were observed on treated cats throughout the study period (Snyder and others 2013). …”

Section: Discussionmentioning

confidence: 99%

“…In contrast, when administered orally, spinosad is not known to have efficacy against other stages of the flea life cycle. Blagburn and others demonstrated that the developmental success of eggs and larvae exposed to debris (flea faeces, skin debris) from treated and untreated dogs was similar, concluding that there is no presence of spinosad in the sebum and skin debris following oral administration (Blagburn and others 2010). In the field study results reported here, there was no additional benefit associated with the use of a product with ovicidal and larvicidal activity combined with adulticidal activity.…”

Section: Discussionmentioning

confidence: 99%

“…In canine studies reported by Blagburn and others, spinosad was shown to be highly effective in this respect, with 100 per cent of fleas ( Ctenocephalides felis ) dead or moribund four hours after its oral administration (Blagburn and others 2010). Rapid flea kill is also seen following spinosad treatment of cats, with signs of flea mortality within 30 minutes of treatment.…”

Section: Introductionmentioning

confidence: 98%

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Evaluation of spinosad for the oral treatment and control of flea infestations on cats in Europe

Franc

Bouhsira

Böhm

et al. 2013

Veterinary Record Open

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MethodsAn ectoparasiticide containing spinosad was evaluated as an oral formulation for cats. Two European laboratory studies and a European multicentre field efficacy and safety study assessed the use of a chewable tablet formulation of spinosad at a dose range of 50–75 mg/kg for treatment and control of flea infestations on cats.ResultsThe studies with experimentally infested cats consistently demonstrated persistent activity against Ctenocephalides felis with >98 per cent efficacy at four weeks post-treatment. In the field study with naturally infested client-owned cats from 18 clinics across Germany and Italy, two monthly doses of spinosad were administered; selamectin was the comparator product. Safety was evaluated in 226 cats, each receiving at least one dose of spinosad or selamectin; both products were well tolerated. 113 spinosad-treated cats and 71 selamectin-treated cats showed >97 per cent reductions in geometric mean flea counts within 14 days post-treatment and at 60 days post-treatment efficacy was >98 per cent in both groups. Analysis of success rates showed 96 per cent in spinosad-treated cats compared with 90.9 per cent in selamectin-treated cats at day 60. The spinosad tablets were successfully administered to over 98 percent of cats. These studies indicate that this formulation of spinosad is safe and efficacious for treatment and prevention of flea infestations in cats.

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“…Subsequently, it was approved for cats in USA, Canada, and Japan in 2012 and in the European Union in 2013. Its excellent efficacy against fleas and its rapid killing effect that are observed in dogs [9–12] are also reported in cats [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas

Cadiergues

Pressanti

2014

ISRN Veterinary Science

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The aims of the study were (i) to describe adult fleas distribution in a strictly indoor cat colony composed of cats with flea allergy dermatitis (FAD) and non-FAD cats and (ii) to evaluate the efficacy of spinosad used alone. Skin lesions were scored according to the SCORing Feline Allergic Dermatitis lesion severity scale (SCORFAD) on days 0, 15, 30, 45, 60, and 90. Cats were combed prior to the treatment (days 0, 30, and 60) and on days 15, 45, and 90; collected fleas were replaced on the animals. All cats received flavored spinosad tablets (Comfortis) at a dosage of 50–75 mg/kg on days 0, 30, and 60. Cats were fed immediately afterwards. On day 0, a total of 60 fleas were collected (mean: 4 ± 4). Cats with FAD had a SCORFAD of 6, 8, 12, and 13 and harbored 0, 2, 1, and 0 fleas, respectively. Tablets were taken voluntarily by 8, 11, and 12 cats on days 0, 30, and 60, respectively. No adverse event was recorded. From day 15 to day 90, no fleas could be collected. SCORFAD was reduced by 40%, 71%, 80%, 89%, and 98% on days 15, 30, 45, 60, and 90, respectively.

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Effects of orally administered spinosad (Comfortis®) in dogs on adult and immature stages of the cat flea (Ctenocephalides felis)

Cited by 43 publications

References 10 publications

Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

Evaluation of spinosad for the oral treatment and control of flea infestations on cats in Europe

Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas

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