Effects of Ovariectomy and Estrogen Replacement Therapy on Visceral Adipose Tissue and Serum Adiponectin Levels in Rats

Babaei, Parvin; Mehdizadeh, Rahimeh; Ansar, Malek Moien; Damirchi, Arsalan

doi:10.1258/mi.2010.010028

Cited by 80 publications

(56 citation statements)

References 34 publications

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“…Our previous studies (Pipatpiboon et al, 2012;Pratchayasakul et al, 2011b) and the present study confirmed that obesity induced by HF consumption impaired peripheral insulin sensitivity, as indicated by increased body weight, visceral fat, plasma glucose level, plasma insulin level, HOMA index, and the total area under the curve (TAUCg). In addition, it has been shown that estrogen deprivation alone also caused obesity, leading to the development of peripheral insulin resistance (Alonso et al, 2006;Babaei et al, 2010). Consistent with those studies, this study showed that 8 weeks after a bilateral ovariectomy, rats had both increased body weight and visceral fat, leading to reduced peripheral insulin sensitivity.…”

Section: Discussionsupporting

confidence: 89%

Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

Pratchayasakul

Sa‐nguanmoo

Sivasinprasasn

et al. 2015

Hormones and Behavior

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Section: Discussionsupporting

confidence: 89%

Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

Pratchayasakul

Sa‐nguanmoo

Sivasinprasasn

et al. 2015

Hormones and Behavior

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“…In the study, ovariectomy resulted in a significant increase in body weight and also an increase in visceral fat, confirming previous findings [36,37], This indicates that the lack of estrogen following ovariectomy influences body weight, partially by increasing visceral fat [1,3]. Estrogen plays a crucial role in distributing visceral fat, probably by changing lipoprotein lipase activity [1,3,38].…”

Section: Discussionsupporting

confidence: 88%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

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Parvin Babaei, Arsalan Damirchi and Rastegar Hoseini. The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats. Vol. 19, No. 3, pp.173-182, 2015 [Purpose] The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.[Methods] Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.[Results] Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.[Conclusion] It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

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“…In OVX animals it was possible for there to be a substantial reduction in body weight via estrogen replacement therapy, due to improved insulin sensitivity, but without an increase in adiponectin production meaning that the beneficial metabolic effects of the weight loss were from a mechanical perspective. 29 One of the challenges associated with the menopause is weight gain due to increased visceral fat, which was linked to as diabetes, hypertension and dyslipidemia. 30 There is mild obesity in the ovariectomized animal model so it can help indicate how adiposity is altered by hypoestrogenism.…”

Section: Discussionmentioning

confidence: 99%

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

Taepongsorat¹,

Phadungkit²

2018

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Background: Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. Objective: To investigate the effects of Asparagus racemosus (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. Methods: Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. Results: Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. Conclusion: It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances. or sam-roi-rak. The extracts of the roots of AR have in the last few years been determined to have a phytoestrogenic effect and help with neurodegenerative disorders, in addition to effects on antidiarrheal, antidyspepsia, adaptogenic, cardioprotective, antibacterial, immunoadjuvant and antitussive.5 There are two major forms in which the root extracts of AR have been used (methanolic and aqueous extracts) as tablets, powders in tablets or a syrup form. 6 In addition, there have been reports of activities related to immunostimulant, antihepatotoxic or antioxytocic. 5 In laboratory animals, there have been recent reports the extracts of AR roots have antioxidant and antidiarrheal effects. [7][8] In rats, the lipid peroxidation (malondialdehyde: MDA) decreased while there were increases in superoxide dismutase (SOD), catalase and ascorbic acid by the methanolic root extracts.

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Effects of Ovariectomy and Estrogen Replacement Therapy on Visceral Adipose Tissue and Serum Adiponectin Levels in Rats

Cited by 80 publications

References 34 publications

Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat

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