Effects of oxidized soybean oil on the performance of sows and jejunum health of suckling piglets

Gao, Feng; Wang, Chuanqi; Zhang, Wentao; Shi, Baoming

doi:10.1111/jpn.13774

Cited by 4 publications

(10 citation statements)

References 52 publications

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“…Some studies have reported that dietary oxidized fish oil decreases average daily gain, significantly increases F/G, decreases the apparent digestibility levels of nutrients from dry matter and ether extract, and increases the diarrhea indices of weaned piglets [42]. However, no effects of oxidized soybean oil on the growth performance levels of piglets are found in our study, similar to the results of Gao et al [43], who found that dietary supplementation with oxidized soybean oil does not affect the performance levels of sows [43]. This suggests that the weaned piglet body itself may have a certain regulatory role to cope with the stress caused by low oxidation degree of oil.…”

Section: Discussionsupporting

confidence: 90%

Resveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets

Gao

Meng

Qin

et al. 2023

J Animal Sci Biotechnol

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Background Oxidized soybean oil (OSO) has been shown to impair growth and exacerbate inflammation, leading to intestinal barrier injury in animals. Recent evidence suggests important roles for resveratrol (RES) in the promoting growth performance, antioxidant capacity, anti-inflammatory, and regulate intestinal barriers in animals. Therefore, The objectives of this study are to investigate the effects of dietary RES (purity 98%) supplementation on the growth performance, antioxidant capacity, inflammatory state, and intestinal function of weaned piglets challenged with OSO. Methods A total of 28 castrated weaned male piglets with a similar body weight of 10.19 ± 0.10 kg were randomly assigned to 4 dietary treatments for 28-d feeding trial with 7 replications per treatment and 1 piglet per replicate. Treatments were arranged as a 2 × 2 factorial with oil type [3% fresh soybean oil (FSO) vs. 3% OSO] and dietary RES (0 vs. 300 mg/kg). Results The results showed that relative to the FSO group, OSO stress tended to decrease the average daily feed intake (ADFI), and decreased the activity levels of lipase, villus/crypt ratio (VCR), the mRNA expression of FABP1, SOD2, IL-10 and ZO-1 in the jejunum, and SOD2, GPX1, occludin and ZO-1 in the colon, the levels of acetic acid in the colonic digesta, whereas up-regulated the mRNA expression of IL-1β and TNF-α in the jejunum (P < 0.05). Moreover, dietary supplementation with RES increased ether extract (EE), the activity levels of sucrase, lipase, α-amylase, villus height (VH) and VCR, the mRNA expression of FABP1, SOD2, IL-10 and occludin in the jejunum, and FABP1, PPAR-γ, GPX1, occludin and ZO-1 in the colon, and the abundance of Firmicutes, acetic and propionic acid, but decreased the levels of D-lactic acid in the plasma, the abundance of Bacteroidetes in the colonic digesta of weaned piglets compared to the non-RES group (P < 0.05). Meanwhile, in the interaction effect analysis, relative to the OSO group, dietary RES supplementation in the diets supplemented with OSO increased the activity levels of trypsin, VH in the jejunum, the abundance of Actinobacteria, the levels of butyric acid of weaned piglets, but failed to influence the activity levels of trypsin and VH, Actinobacteria abundance, the levels of butyric acid when diets were supplemented with FSO (interaction, P < 0.05). Relative to the OSO group, dietary RES supplementation in the diets supplemented with OSO decreased the activity levels of DAO in the plasma of weaned piglets but failed to influence the activity levels of DAO when diets were supplemented with FSO (interaction, P < 0.05). Relative to the FSO group, dietary RES supplementation in the diets supplemented with FSO decreased the level of propionic acid, whereas RES supplementation failed to influence the level of propionic acid when the diet was supplemented with OSO (interaction, P < 0.01). Conclusions Inclusion of OSO intensified inflammatory states and impaired the intestinal health characteristics of weaned piglets. Dietary RES supplementation improved the antioxidant capacity, anti-inflammatory activity, and intestinal morphology. Further studies showed that the protective effects of RES on gut health could be linked to the decreased abundance of Prevotella_1, Clostridium_sensu_stricto_6, and Prevotellaceae_UCG003 and increased levels of acetic and propionic acid.

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Section: Discussionsupporting

confidence: 90%

Resveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets

Gao

Meng

Qin

et al. 2023

J Animal Sci Biotechnol

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“…can be produced by activating NF-κB at the molecular level. , Therefore, OSO may damage the liver by affecting oxidative stress and inflammatory immune response. We previously showed that adding peroxide oil to sows’ diets can cause intestinal tissue inflammation in offspring . Another study showed similar results that feeding oxidized rapeseed oil resulted in the activation of oxidative stress factor nuclear factor erythroid-derived 2-like 2 (Nrf2) and the activation of inflammatory pathway NF-κB .…”

Section: Discussionmentioning

confidence: 74%

“…We previously showed that adding peroxide oil to sows' diets can cause intestinal tissue inflammation in offspring. 23 Another study showed similar results that feeding oxidized rapeseed oil resulted in the activation of oxidative stress factor nuclear factor erythroidderived 2-like 2 (Nrf2) and the activation of inflammatory pathway NF-κB. 42 In addition, feeding oxidized fish oil exacerbated liver inflammation, resulting in increased proinflammatory cytokines, while anti-inflammatory cytokines (IL-10) are lowered.…”

Section: ■ Discussionmentioning

confidence: 87%

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Oxidized Soybean Oil Evoked Hepatic Fatty Acid Metabolism Disturbance in Rats and their Offspring

Gao,

Guan,

Zhang

et al. 2023

J. Agric. Food Chem.

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The oxidation of fats and oils is an undisputed subject of science, given the effect of oxidized fats and oils on food quality and safety. This study aimed to determine whether maternal exposure to oxidized soybean oil (OSO) causes lipid metabolism disorders in the liver and whether this lipid metabolism disorder can be transmitted to offspring or even worsened. A total of 60 female Sprague–Dawley (SD) rats were divided randomly into four groups in this study. Treatment groups received a pure diet of OSO with a peroxide value of 200, 400, or 800 mEqO2/kg, while the control group received fresh soybean oil (FSO). As for our results, OSO affected serum biochemical parameters in the maternal generation (F0) and induced liver histopathology changes, inflammation, and oxidative stress. Moreover, the expression of genes related to the liver X receptor α (LXRα)sterol regulatory element binding protein-1c (SREBP-1c) signaling pathway was changed. Similar trends were found in the livers of offspring on postnatal days 21 and 56. In conclusion, exposure to OSO during gestation and lactation can affect liver lipid synthesis. Additionally, it is detrimental to the development of the offspring’s liver, affecting fatty acid metabolism and causing liver damage.

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“…Our previous studies have shown that maternal exposure to OSO damages the placental, 29 the offspring's liver, 30 kidney, 31 and intestine. 32,33 Hence, it is especially significant to seek out a way to mitigate the damage of an OSO to both maternal and offspring.…”

Section: ■ Introductionmentioning

confidence: 99%

Dietary Resveratrol Ameliorates Hepatic Fatty Acid Metabolism and Jejunal Barrier in Offspring Induced by Maternal Oxidized Soybean Oil Challenge

Gao,

Liu,

et al. 2024

J. Agric. Food Chem.

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Increasing evidence indicates that maternal exposure to oxidized soybean oil (OSO) causes damage to the mother and offspring. The antioxidant resveratrol (Res) has a variety of health benefits. However, the protective effect of Res on mitigating offspring damage after maternal exposure to OSO and its mechanism remains unclear. Therefore, this study aimed to investigate the effect of Res on hepatic fatty acid metabolism and the jejunal barrier in suckling piglets after maternal OSO exposure. A total of 18 sows in late gestation were randomly assigned to three treatments. The sows were fed with a fresh soybean oil (FSO) diet, an OSO diet, or the OSO diet supplemented with 300 mg/kg Res (OSO + Res), respectively. The results showed that maternal supplementation of Res restored the mRNA levels of genes related to fatty acid metabolism and increased the activities of catalase (CAT) and total superoxide dismutase (T-SOD) in suckling piglets' livers under the OSO challenge. Moreover, the OSO + Res group restored the mRNA levels of occludin and claudin 4 in suckling piglet jejunum compared with the results of the OSO challenges. In summary, supplementation with Res improves hepatic fatty acid metabolism and intestinal barrier function of suckling piglets after maternal OSO challenge during late gestation and lactation.

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Effects of oxidized soybean oil on the performance of sows and jejunum health of suckling piglets

Cited by 4 publications

References 52 publications

Resveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets

Resveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets

Oxidized Soybean Oil Evoked Hepatic Fatty Acid Metabolism Disturbance in Rats and their Offspring

Dietary Resveratrol Ameliorates Hepatic Fatty Acid Metabolism and Jejunal Barrier in Offspring Induced by Maternal Oxidized Soybean Oil Challenge

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