Effects of p.C430S polymorphism in the <i>PPARGC1A</i> gene on muscle fibre type composition and meat quality in Yorkshire pigs

Kim, J. M.; Lee, K. T.; Lim, Kyu-Sang; Park, E. W.; Lee, Y. S.; Hong, Kyung Pyo

doi:10.1111/j.1365-2052.2010.02042.x

Cited by 15 publications

(9 citation statements)

References 13 publications

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“…FHL1 has been identified as a regulator of skeletal muscle mass [57]. PPARGC1A was considered as a functional candidate gene for muscle fiber type composition and meat quality in pig [58]. ANKRD1 and MYOZ2 were found to be related to muscular dystrophy [59], [60].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analyses by Sequencing of Transcriptomes during Skeletal Muscle Development between Pig Breeds Differing in Muscle Growth Rate and Fatness

et al. 2011

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Understanding the dynamics of muscle transcriptome during development and between breeds differing in muscle growth is necessary to uncover the complex mechanism underlying muscle development. Herein, we present the first transcriptome-wide longissimus dorsi muscle development research concerning Lantang (LT, obese) and Landrace (LR, lean) pig breeds during 10 time-points from 35 days-post-coitus (dpc) to 180 days-post-natum (dpn) using Solexa/Illumina's Genome Analyzer. The data demonstrated that myogenesis was almost completed before 77 dpc, but the muscle phenotypes were still changed from 77 dpc to 28 dpn. Comparative analysis of the two breeds suggested that myogenesis started earlier but progressed more slowly in LT than in LR, the stages ranging from 49 dpc to 77 dpc are critical for formation of different muscle phenotypes. 595 differentially expressed myogenesis genes were identified, and their roles in myogenesis were discussed. Furthermore, GSK3B, IKBKB, ACVR1, ITGA and STMN1 might contribute to later myogenesis and more muscle fibers in LR than LT. Some myogenesis inhibitors (ID1, ID2, CABIN1, MSTN, SMAD4, CTNNA1, NOTCH2, GPC3 and HMOX1) were higher expressed in LT than in LR, which might contribute to more slow muscle differentiation in LT than in LR. We also identified several genes which might contribute to intramuscular adipose differentiation. Most important, we further proposed a novel model in which MyoD and MEF2A controls the balance between intramuscular adipogenesis and myogenesis by regulating CEBP family; Myf5 and MEF2C are essential during the whole myogenesis process while MEF2D affects muscle growth and maturation. The MRFs and MEF2 families are also critical for the phenotypic differences between the two pig breeds. Overall, this study contributes to elucidating the mechanism underlying muscle development, which could provide valuable information for pig meat quality improvement.The raw data have been submitted to Gene Expression Omnibus (GEO) under series GSE25406.

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Section: Discussionmentioning

confidence: 99%

Comparative Analyses by Sequencing of Transcriptomes during Skeletal Muscle Development between Pig Breeds Differing in Muscle Growth Rate and Fatness

et al. 2011

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“…These accumulating SNP data not only provide candidate genetic markers for breed selection of farm animals, but also lead to mechanistic understanding of how external factors regulate fiber type diversity. For instance, several SNP, identified in the gene PPAR γ coactivator 1 α ( PGC-1a ), a transcriptional coactivator enriched in type I fiber, can affect muscle fiber characteristics and meat quality traits of pigs (Lin et al, 2002; Haegeman et al, 2003; Kim et al, 2010; Lee et al, 2011). It has been shown that PGC-1α-induced fiber type switching is mediated by and requires hypoxia-inducible factor 2α ( HIF2α ), and ablation of HIF2 α in differentiated myocytes using myogenin-cre driver mice resulted in the switch of slow fiber type toward fast fiber type (Rasbach et al, 2010).…”

Section: Regulation Of Muscle Fiber Type Composition and Meat Productmentioning

confidence: 99%

MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM: Stem cell niche and postnatal muscle growth1,2

Kuang

2012

Journal of Animal Science

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Stem cell niche plays a critical role in regulating the behavior and function of adult stem cells that underlie tissue growth, maintenance, and regeneration. In the skeletal muscle, stem cells, called satellite cells, contribute to postnatal muscle growth and hypertrophy, and thus, meat production in agricultural animals. Satellite cells are located adjacent to mature muscle fibers underneath a sheath of basal lamina. Microenvironmental signals from extracellular matrix mediated by the basal lamina and from the host myofiber both impinge on satellite cells to regulate their activity. Furthermore, several types of muscle interstitial cells, including intramuscular preadipocytes and connective tissue fibroblasts, have recently been shown to interact with satellite cells and actively regulate the growth and regeneration of postnatal skeletal muscles. From this regard, interstitial adipogenic cells are not only important for marbling and meat quality, but also represent an additional cellular component of the satellite cell niche. At the molecular level, these interstitial cells may interact with satellite cells through cell surface ligands, such as delta-like 1 homolog (Dlk1) protein whose overexpression is thought to be responsible for muscle hypertrophy in callipyge sheep. In fact, extracellular Dlk1 protein has been shown to promote the myogenic differentiation of satellite cells. Understanding the cellular and molecular mechanisms within the stem cell niche that regulate satellite cell differentiation and maintain muscle homeostasis may lead to promising approaches to optimizing muscle growth and composition, thus improving meat production and quality.

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“…In contrast, investigations in swine revealed significant effects of nucleotide variation at the PPARGC1A locus on muscle fiber characteristics and meat quality traits (e.g. 135-137. Erkens et al (2008) 138 described two novel splice variants of porcine PPARGC1A that were also detected in human tissue.…”

Section: Myokines - An Emerging New Class Of Secreted Proteinsmentioning

confidence: 99%

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

Komolka¹,

Albrecht²,

Wimmers³

et al. 2014

J. Genomics

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Adipose tissue is considered as a major endocrine organ that secretes numerous proteins called adipokines. The heterogeneous nature of adipose tissue in different parts of the body suggests respective heterogeneity of proteomes and secretomes. This review consolidates knowledge from recent studies targeting the diversity of different adipose depots affecting the pattern of secreted adipokines and discusses potential consequences for the cross-talk between adipose and skeletal muscle in humans, rodent models and farm animals. Special attention is paid to muscle-associated fat depots like inter- and intramuscular fat that become focus of attention in the context of the rather new notion of skeletal muscle as a major endocrine organ. Understanding the complexity of communication between adipocytes and skeletal muscle cells will allow developing strategies for improvement of human health and for sustainable production of high quality meat.

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Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs

Cited by 15 publications

References 13 publications

Comparative Analyses by Sequencing of Transcriptomes during Skeletal Muscle Development between Pig Breeds Differing in Muscle Growth Rate and Fatness

Comparative Analyses by Sequencing of Transcriptomes during Skeletal Muscle Development between Pig Breeds Differing in Muscle Growth Rate and Fatness

MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM: Stem cell niche and postnatal muscle growth1,2

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

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