2013
DOI: 10.1016/j.brs.2013.05.005
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Effects of Pedunculopontine Area and Pallidal DBS on Gait Ignition in Parkinson's Disease

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Cited by 28 publications
(29 citation statements)
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“…Vim receives strong inputs from the cerebellum, and the effectiveness of tremor control with DBS at this location is a strong argument in favor of cerebellar involvement in the pathophysiology of tremor. PPN DBS [226][227][228][229][230][231][232][233][234][235][236][237][238][239], alone or in combination with STN or GPi DBS, is currently under study for patients with advanced PD who develop levodopaunresponsive freezing of gait, balance impairments, and falls. DBS of the PPN has been shown to be most effective at low stimulation frequencies [240].…”
Section: Use Of Dbs In Pdmentioning
confidence: 99%
“…Vim receives strong inputs from the cerebellum, and the effectiveness of tremor control with DBS at this location is a strong argument in favor of cerebellar involvement in the pathophysiology of tremor. PPN DBS [226][227][228][229][230][231][232][233][234][235][236][237][238][239], alone or in combination with STN or GPi DBS, is currently under study for patients with advanced PD who develop levodopaunresponsive freezing of gait, balance impairments, and falls. DBS of the PPN has been shown to be most effective at low stimulation frequencies [240].…”
Section: Use Of Dbs In Pdmentioning
confidence: 99%
“…Further, studies have used different landmarks when assessing their data, including the AC-PC or the B-F system. Another issue is that, even when electrodes were placed in apparently the same brainstem region, patients were stimulated through different contacts (some in the caudal PPN, others in the rostral PPN) [6,7,8,13,17,22,23,25,28,30,52,53]. …”
Section: Postoperative Imagingmentioning
confidence: 99%
“…In a more recent study, it was demonstrated that low-frequency PPN DBS combined with high-frequency GPi DBS in a patient with advanced PD had a marked impact on gait ignition and freezing of gait. In contrast, isolated PPN or GPi DBS yielded only mild effects with the patient trial being blinded in each condition and by using a computerized gait analysis system [17]. …”
Section: Combination With Other Targetsmentioning
confidence: 99%
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“…The nucleus ventralis intermedius (VIM) of the thalamus is a standard target for alleviating tremor in PD. 125 The pedunculopontine tegmental nucleus is a target for gait disorder 25,171 and sleep modulation, 159 sometimes in tandem with stimulation of other nuclei. 90,195 Other targets in early stages of exploration include the posterior subthalamic area, caudal zona incerta, prelemniscal radiation, thalamic centromedian-parafascicular complex, and cerebral cortex.…”
Section: Current Approach To Therapymentioning
confidence: 99%