Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

Jiang, Peng; Wang, Jianshe; Zhang, Jinguo; Dai, Jiayin

doi:10.1016/j.jes.2015.10.030

Cited by 7 publications

(11 citation statements)

References 74 publications

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“…We demonstrated that the primary site of PCP accumulation was the quail kidney, with the high levels of PCP in the kidney and liver possibly indicating key elimination and metabolism routes. These results are consistent with PCP accumulation studies on white-rumped munia (Lonchura striata), in which the kidney and liver exhibited the highest and second highest PCP content, respectively (Jiang et al, 2016).…”

Section: Discussionsupporting

confidence: 88%

“…inducer (Jung et al, 2001). However, it is unknown whether this occurs within the quail, which deserves further research (Jiang et al, 2016).…”

Section: Discussionmentioning

confidence: 98%

“…We conducted PCP quantification via extraction into an organic solvent and then gas chromatography with electron capture detection. Details on the method detection limit (MDL) and procedural blanks are as described in previous research (Jiang et al, 2016).…”

Section: Pcp Content In Tissuesmentioning

confidence: 99%

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Effects of pentachlorophenol on the quail ( Coturnix japonica ) liver detoxification pathway

et al. 2017

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Pentachlorophenol (PCP), an extensively used pesticide and biocide, is of critical environmental concern due to its toxicity and recalcitrance to degradation. In this study, the effect of PCP on induction of transcription factors, cytochrome P450 (CYP450) genes, and the antioxidative enzyme system were investigated in the quail liver. A total of 60 (4- to 6-week-old) male quails (Coturnix japonica) were administered 0, 0.05, 0.5, and 5 mg/kg/d PCP orally for 42 d. Following exposure, both absolute and relative liver weights were significantly lower than those of the control. Using gas chromatography-mass spectrometry, PCP accumulation was, from highest to lowest, kidney > liver > muscle for all exposure groups. The expressions of CYP1A5, CYP1B1, CYP2C18, nuclear translocator 1 (ARNT1), and aryl hydrocarbon receptor 1 (AHR1) were induced after PCP treatment, and increases were found in the activities of hepatic superoxide dismutase (SOD) and catalase (CAT), and the content of hepatic malondialdehyde (MDA). In addition, exposure to PCP induced an increase in liver 8-hydroxydeoxyguanosine (8-OHdG) and significantly elevated ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and 7-ethoxycoumarin-O-deethylase (ECOD) activity, but decreased that of glutathione peroxidase (GSH-Px), benzyloxyresorufin O-debenzylase (BROD), pentoxyresorufin O-depentylase (PROD), and erythromycin N-demethylase (END). No significant responses were observed for benzyloxy-trifluoromethyl-coumarin (BFC). The protein level of liver nuclear factor κB (NF-κB) was higher, whereas that of nuclear factor E2-related factor 2 (Nrf2) was lower for exposed quail. These results suggest that PCP affects quail oxidative stress by modulating CYP450 enzymes and nuclear transcription factors.

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Section: Discussionsupporting

confidence: 88%

“…inducer (Jung et al, 2001). However, it is unknown whether this occurs within the quail, which deserves further research (Jiang et al, 2016).…”

Section: Discussionmentioning

confidence: 98%

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Effects of pentachlorophenol on the quail ( Coturnix japonica ) liver detoxification pathway

et al. 2017

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“…Group II received PSO (0.15 ml/kg bw), group III received PCP (40 mg/kg bw) and group IV was administrated PSO+PCP (0.15 ml/kg bw+40 mg/kg bw) intragastrically using a 22 G ball tip needle for 28 days, respectively. Applied PSO and PCP doses are determined from previous studies (1,8,24,38,44,48). Twenty four Zeynep SOYER SARICA hours after the last administration, tissue samples from brain, liver, kidney, testis and spleen of the rats were collected under light ether anaesthesia.…”

Section: Experimental Protocolmentioning

confidence: 99%

“…The most important target tissue is liver. Depending on the exposed dose, in addition to the some changes in the biochemical parameters, hepatic P450 enzyme activities, liver weight and in the liver microscopy are also observed (24,25,29,38,49). PCP has also toxic effects on kidneys.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues

Sarıca¹

2018

Erciyes Üniversitesi Veteriner Fakültesi Dergisi

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This study was conducted to evaluate the effects of pomegranate seed oil PSO on the oxidative stress induced by pentachlorophenol PCP in rats. Fourty Sprague-Dawley, 4-5 months old, 300g male rats were used in this study. Rats were assigned to four groups each containing 10 animals. First group was control group; no administration was made to animals in this group. Second, third and fourth groups were given PSO at a dose of 0.15 ml/kg bw, PCP at a dose of 40 mg/kg bw and PSO at a dose of 0.15 ml/kg bw+PCP at a dose of 40 mg/kg bw orally by gavage for 28 days, respectively. At the end of the study, brain, liver, kidney, testicle and spleen samples were collected. Malondialdehyde (MDA) level and catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were measured in tissue samples. PCP caused an increase of MDA level in brain, kidney, liver and testicle; a decrease of CAT activity in liver and spleen; a decrease of GSH-Px activity in brain and testicle and a decrease of SOD activity in brain, liver and kidney compared to control group. When PSO+PCP group compared to PCP group, MDA level decreased in brain, liver and testicle; CAT activity increased in spleen; SOD activity increased in brain and kidney. When compared to the control group and the group given PSO+PCP, the data of PSO+PCP group were generally similar to the control group. As a result, administration of PCP at the dose of 40 mg/kg bw for 28 days caused oxidative stress and administration of PSO at the dose of 0.15 ml/kg bw alleviated severity of PCP induced oxidative stress. Rat Dokularında Pentaklorofenol Toksisitesine Karşı Nar Çekirdeği Yağının Antioksidan EtkileriÖzet: Bu çalışma ratlarda pentachlorophenol PCP'nin oluşturduğu oksidatif stres üzerine nar çekirdeği yağının (NÇY) etkilerinin değerlendirilmesi için yapıldı. Çalışmada 4-5 aylık, ortalama 300 g ağırlığında 40 adet Sprague-Dawley ırkı erkek sıçan kullanıldı ve her birinde 10 hayvan olmak üzere dört grup oluşturuldu. İlk grup kontrol olarak belirlendi ve herhangi bir uygulama yapılmadı. İkinci, üçüncü ve dördüncü gruba sırasıyla 0.15 ml/kg ca dozunda NÇY, 40 mg/kg ca dozunda PCP ve 0.15 ml/kg ca dozunda NÇY ile 40 mg/kg ca dozunda PCP 28 gün boyunca gavaj yolu ile mideye uygulandı. Çalışmanın sonunda beyin, karaciğer, böbrek, testis ve dalak dokuları alındı. Doku örneklerinde malondialdehit (MDA) düzeyi ile katalaz (CAT), glutasyon peroksidaz (GSH-Px) ve superoksit dismutaz (SOD) aktiviteleri ölçüldü. Pentaklorofenolün kontrol grubuna göre, beyin, karaciğer, böbrek ve testiste MDA düzeyinde yükselme; karaciğer ve dalak CAT aktivitesinde azalma; beyin ve testis GSH-Px aktivitesinde azalma; beyin, böbrek ve karaciğer SOD aktivitesinde azalmaya neden oldu. NÇY+PCP verilen grup PCP verilen grupla karşılaştırıldığında beyin, karaciğer ve testis MDA düzeyinde azalma; dalak CAT aktivitesinde yükselme; beyin ve böbrek SOD aktivitesinde yükselmeye yol açtı. NÇY+PCP verilen grup ve kontrol grubu karşılaştırıldığında, NÇY+PCP grup verileri genel olarak kontrol grubuy...

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Pentachlorophenol-induced hemotoxicity diminishes antioxidant potential and oxidizes proteins, thiols, and lipids in rat blood: An in vivo study

Maheshwari

Khan

Mahmood

et al. 2023

Heliyon

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Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

Cited by 7 publications

References 74 publications

Effects of pentachlorophenol on the quail ( Coturnix japonica ) liver detoxification pathway

Effects of pentachlorophenol on the quail ( Coturnix japonica ) liver detoxification pathway

Antioxidant Effects of Pomegranate Seed Oil Against Pentachlorophenol Toxicity in Rat Tissues

Pentachlorophenol-induced hemotoxicity diminishes antioxidant potential and oxidizes proteins, thiols, and lipids in rat blood: An in vivo study

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