Effects of perinatal exposure to waterborne fluoxetine on memory processing in the cuttlefish Sepia officinalis

Poi, Carole Di; Darmaillacq, Anne-Sophie; Dickel, Ludovic; Boulouard, Michel; Bellanger, Cécile

doi:10.1016/j.aquatox.2013.02.004

Cited by 66 publications

(30 citation statements)

References 55 publications

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“…Few studies report chronic toxicity data (reviewed by Santos et al 2 ). 48 Nonetheless, given their continuous discharge into the environment, organisms are exposed 49 throughout their entire lifetimes over several generations. Studies assessing transgenerational 50 effects through multi-generational exposure are needed to have a more ecologically-relevant 51 vision of the impact of pharmaceutical residues on ecosystems.…”

Section: Introductionmentioning

confidence: 99%

Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia magna Life History Traits

Minguez

Ballandonne

Rakotomalala

et al. 2015

Environ. Sci. Technol.

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The low levels of antidepressants detected in surface waters currently raise concern about their potential long-term risks to nontarget aquatic organisms. We investigated the transgenerational effects of sertraline, a selective serotonin reuptake inhibitor, and venlafaxine, a serotonin-norepinephrine reuptake inhibitor, on the life traits of Daphnia magna over two generations under environmentally realistic concentrations. We also studied the reversibility of the effect using recovery experiments. We assessed daphnid survival, growth, and reproduction over 21 days and evidenced detectable effects of the antidepressants. Sertraline increased the F0-daphnid fecundity whereas it decreased the offspring number of F1-daphnids. Transfer to clean medium caused negative effects on the offspring of daphnids exposed to 0.3 μg L(–1), but improved the fecundity of offspring of daphnids exposed to 100 μg L(–1). Venlafaxine exposure decreased the offspring number of F0-daphnids and resulted in drug tolerance in the F1 generation. Sertraline, unlike venlafaxine, may turn out to be a true environmental threat due to its accumulation in algae and the physiological weakness observed over generations. These effects across generations point out to the need to perform multigeneration tests to assess the environmental risk of pharmaceuticals in nontarget organisms.

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Section: Introductionmentioning

confidence: 99%

Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia magna Life History Traits

Minguez

Ballandonne

Rakotomalala

et al. 2015

Environ. Sci. Technol.

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“…Thus, they are interesting and potentially significant in terms of their capacity to affect changes to behaviour and other ecologically important traits in wildlife (table 1; e.g. [44,[81][82][83]). Carbamazepine, for example, which is used to treat epilepsy and bipolar disorder, seems to be ubiquitous in sewage-contaminated ecosystems, dominating samples taken from different matrices, species and at all trophic levels examined [44,45].…”

Section: Pharmaceutical Effects At Individual and Population Levelsmentioning

confidence: 99%

Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems

Arnold

Brown

Ankley

et al. 2014

Phil. Trans. R. Soc. B

362

187

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Global pharmaceutical consumption is rising with the growing and ageing human population and more intensive food production. Recent studies have revealed pharmaceutical residues in a wide range of ecosystems and organisms. Environmental concentrations are often low, but pharmaceuticals typically are designed to have biological effects at low doses, acting on physiological systems that can be evolutionarily conserved across taxa. This Theme Issue introduces the latest research investigating the risks of environmentally relevant concentrations of pharmaceuticals to vertebrate wildlife. We take a holistic, global view of environmental exposure to pharmaceuticals encompassing terrestrial, freshwater and marine ecosystems in high- and low-income countries. Based on both field and laboratory data, the evidence for and relevance of changes to physiology and behaviour, in addition to mortality and reproductive effects, are examined in terms of the population- and community-level consequences of pharmaceutical exposure on wildlife. Studies on uptake, trophic transfer and indirect effects of pharmaceuticals acting via food webs are presented. Given the logistical and ethical complexities of research in this area, several papers focus on techniques for prioritizing which compounds are most likely to harm wildlife and how modelling approaches can make predictions about the bioavailability, metabolism and toxicity of pharmaceuticals in non-target species. This Theme Issue aims to help clarify the uncertainties, highlight opportunities and inform ongoing scientific and policy debates on the impacts of pharmaceuticals in the environment.

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“…Recently, some studies reported toxicity results at levels close to environmental concentrations-this is a subject of controversy. Di Poi et al (2013) and Franzellitti et al (2013) reported behavioral effects of the antidepressant fluoxetine on Sepia officinalis cuttlefish and transcriptional effects on the M. galloprovincialis marine mussel, respectively, both at concentrations of 1 ng/L or less. Sumpter and Margiotta-Casaluci (2014) questioned the relevance and significance of these results in a commentary paper, and highlighted the lack of pharmacological and pharmacokinetic data in aquatic organisms exposed to such molecules.…”

Section: What About Marine Organismsmentioning

confidence: 97%

Occurrence of PPCPs in the marine environment: a review

Arpin-Pont

Bueno

Góméz

et al. 2014

Environ Sci Pollut Res

219

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Little research has been conducted on the occurrence of pharmaceuticals and personal care products (PPCPs) in the marine environment despite being increasingly impacted by these contaminants. This article reviews data on the occurrence of PPCPs in seawater, sediment, and organisms in the marine environment. Data pertaining to 196 pharmaceuticals and 37 personal care products reported from more than 50 marine sites are analyzed while taking sampling strategies and analytical methods into account. Particular attention is focused on the most frequently detected substances at highest concentrations. A snapshot of the most impacted marine sites is provided by comparing the highest concentrations reported for quantified substances. The present review reveals that: (i) PPCPs are widespread in seawater, particularly at sites impacted by anthropogenic activities, and (ii) the most frequently investigated and detected molecules in seawater and sediments are antibiotics, such as erythromycin. Moreover, this review points out other PPCPs of concern, such as ultraviolet filters, and underlines the scarcity of data on those substances despite recent evidence on their occurrence in marine organisms. The exposure of marine organisms in regard to these insufficient data is discussed.

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Effects of perinatal exposure to waterborne fluoxetine on memory processing in the cuttlefish Sepia officinalis

Cited by 66 publications

References 55 publications

Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia magna Life History Traits

Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia magna Life History Traits

Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems

Occurrence of PPCPs in the marine environment: a review

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