Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats

Li, Xinwang; Li, Jun-Xu; Zhu, Xiaocui; Cui, Ruisi; Jiao, Jingjing

doi:10.1016/j.bbr.2009.09.016

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…With regard to the Sal+Mor group, the locomotor activity induced by co-administration of 0.4 mg/kg huperzine A and morphine on day 22 was not as marked compared with the group challenged with saline and morphine on day 18. This indicates that 0.4 mg/kg huperzine A may suppress the expression of behavioral sensitization caused by morphine, which was in agreement with the results obtained from previous studies investigating other acetylcholinesterase inhibitors, such as physostigmine (17).…”

Section: Discussionsupporting

confidence: 92%

“…Locomotor activity, as a measure of spontaneous behavior, has been primarily assessed in behavioral sensitization studies (14,15). Additionally, behavioral sensitization has been established in rodents that have repeatedly been administered the same or incremental doses of a drug (16)(17)(18)(19). It has been demonstrated that behavioral sensitization may also be applied in a model of testing addictive behavior associated with drug seeking and relapse (12,20).…”

Section: Introductionmentioning

confidence: 99%

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Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats

Sun

Tian

Cui

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Acetylcholinesterase inhibitors are regarded as promising therapeutic agents to treat addiction. The current study aimed to examine the effects of huperzine A, a cholinesterase inhibitor, on behavioral sensitization induced by repeated morphine administration and relapse induced by contextual conditioning. The present study also assessed whether the state-dependency hypothesis may explain the results. Adult rats were divided into four groups (n=8) and intraperitoneally injected with 0.2, 0.3 or 0.4 mg/kg huperzine A or saline (1 ml/kg, control), for 5 days. The effect of repeated huperzine A administration alone on locomotor activity was assessed. For the experiments that analyzed the development of morphine-induced sensitization, 40 rats were divided into five groups (n=8): Saline+Saline, Saline+Morphine, 0.2, 0.3 and 0.4 mg/kg huperzine A+Morphine. Following a withdrawal period of 7 days, all animals were administered saline or morphine, as appropriate. To test the state-dependency hypothesis, the rats in the Saline+Morphine group were injected with saline and morphine, while the other three groups were administered different doses of huperzine A and morphine. To examine the effect of huperzine A on the expression of morphine-induced sensitization, the rats in huperzine A+Morphine groups were injected with appropriate concentrations of huperzine A, and morphine. The current results indicated that the administration of huperzine A alone did not affect locomotor activity, while higher doses of huperzine A inhibited the addictive behavior induced by morphine at the development phase. Additionally, huperzine A administration during the expression phase of morphine sensitization did not inhibit the relapse induced by administration of saline.Furthermore, 0.4 mg/kg huperzine A inhibited the expression of morphine-induced behavioral sensitization. Therefore, the results of the current study do not support the state-dependency hypothesis.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats

Sun

Tian

Cui

et al. 2017

Experimental and Therapeutic Medicine

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“…1), whereas context-associated hyperactivity requires the longer periods and perhaps a period of abstinence. These results are similar to the study conducted by the group of Li6, although there are differences in training session and abstinence period. Also, Kosowski et al4 have shown that the conditioned response to nicotine could not be demonstrated until the sensitized locomotor activity response reached a plateau phase, which suggests that a maximal level in the expression of behavioural sensitization to nicotine precedes the onset of conditioned increase of locomotor activity.…”

Section: Discussionsupporting

confidence: 89%

“…The acquisition of conditioned hyperactivity and behavioral sensitization sessions has been described in detail previously6 with modifications. Briefly, 41 rats were randomly assigned into one of four groups (see Table 1).…”

Section: Methodsmentioning

confidence: 99%

“…A major contributor to relapse is exposure to environmental stimuli that have previously been associated regularly with drugs3. Many studies have shown that neutral clues can acquire excitatory locomotor (hyperactivity) effect in a drug free state when drug administration is repeatedly paired with those clues4567. Locomotor sensitization refers to a progressive and persistent increase in the psychomotor activating effects of drugs (e.g.…”

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confidence: 99%

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Differential effects of propranolol on conditioned hyperactivity and locomotor sensitization induced by morphine in rats

Wei

2014

Sci Rep

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According to memory reconsolidation theory, when long-term memory is reactivated by relevant clues, the memory traces become labile, which can be altered by pharmacological manipulations. Accumulating evidence reveals that memory related to drug abuse can be erased by disrupting reconsolidation process. We used an animal model that could simultaneously measure conditioned hyperactivity and locomotor sensitization induced by morphine. β-adrenoceptor antagonist propranolol or saline were administered following conditioned stimuli (CS) or a small dose of morphine reactivation. The results showed that the conditioned hyperactivity could be disrupted by propranolol treatment following CS reactivation. However, the expression of locomotor sensitization could not be disrupted by propranolol administration following CS or morphine reactivation. Furthermore, morphine injection and propranolol intervention enhanced the locomotor sensitization effect. These data suggest that blocking the reconsolidation process can disrupt the conditioned hyperactivity induced by environmental cues associated with morphine treatment, but not morphine-induced locomotor sensitization.

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Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation

Leite¹,

Bastos²,

Samuels

et al. 2019

Behavioural Brain Research

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Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats

Cited by 8 publications

References 30 publications

Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats

Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats

Differential effects of propranolol on conditioned hyperactivity and locomotor sensitization induced by morphine in rats

Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation

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