Effects of preoperative magnesium therapy on arrhythmias and myocardial ischemia during off-pump coronary surgery

Beşoğul, Yavuz; Gemalmaz, Hüseyin; Aslan, Recep

doi:10.4103/1817-1737.53355

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Heart manipulation during off-pump CABG may cause hemodynamic instability. [15] Magnesium supplementation before beating heart can stabilize the plasma membrane of the myocardium and thereby mediate the protective effect. Low levels of magnesium cause not only cardiac arrhythmias like atrial fibrillation, [14] but also hypertension and vasoconstriction.…”

Section: Discussionmentioning

confidence: 99%

Serum Magnesium Levels in Off - Pump Coronary Artery Bypass Grafting

Manne¹,

Ravisekhar²

2015

jemds

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ABSTRACT:Magnesium plays an essential role in cardiac protection. Magnesium has many beneficial effects like it improves contractility and reduces the number of cardiac arrhythmia episodes. The aim of the study was to analyze the magnesium concentration in patients undergoing off-pump CABG. The study included 110 patients who underwent general anesthesia and coronary artery bypass graft. Magnesium level was 2.0mg/dl at baseline, 2.18 mg/dl, 2.02 mg/dl and 1.94 mg/dl respectively on 3 consecutive days post-operatively. The lowering of magnesium recommends routine serum magnesium determination to prevent complications.

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Section: Discussionmentioning

confidence: 99%

Serum Magnesium Levels in Off - Pump Coronary Artery Bypass Grafting

Manne¹,

Ravisekhar²

2015

jemds

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“…All the clinical effects for the use of magnesium sulfate in anesthesia presented by the anesthesiologists participating in this survey have been reported in other publications, including various systematic reviews and meta-analyses, although some of them are still subjects of controversy Beşogul et al, 2009; Gozdemir et al, 2010; Rhee et al, 2012; Abdulatif et al, 2013; Rotava et al, 2013; Agrawal et al, 2014; Ahsan et al, 2014; Crowther et al, 2014; Kahraman and Eroglu, 2014; Kew et al, 2014; Marzban et al, 2014; Rodrigo et al, 2014; Srebro et al, 2014; Uludag et al, 2014; Berhan and Berhan, 2015; Kim et al, 2015; Safavi et al, 2015; Vigil-De Gracia and Ludmir, 2015; Demiroglu et al, 2016; Green, 2016; Griffiths and Kew, 2016; Jangra et al, 2016; Juibari et al, 2016; Maged et al, 2016; Naghipour et al, 2016; Rodríguez-Rubio et al, 2016, 2017; Soltani et al, 2016; Thomas and Behr, 2016; Ulm et al, 2016; Vendrell et al, 2016; Xie et al, 2016, 2017; Brookfield et al, 2017; Haryalchi et al, 2017; Kutlesic et al, 2017; Lecuyer et al, 2017; McKeown et al, 2017; Mendonca et al, 2017; Salaminia et al, 2018; Zhang et al, 2018.…”

Section: Discussionmentioning

confidence: 86%

“…The magnesium sulfate doses reported in this survey are in accordance with those found in other publications. There are reports of magnesium sulfate induction doses in general anesthesia from 15 mg.kg −1 to 75 mg.kg −1 (Beşogul et al, 2009; Gozdemir et al, 2010; Rotava et al, 2013; Kahraman and Eroglu, 2014; Rodrigo et al, 2014; Honarmand et al, 2015; Rower et al, 2017) and doses up to 50 mg.kg −1 in sedation (Lecuyer et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Use Profile of Magnesium Sulfate in Anesthesia in Brazil

et al. 2019

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Objectives: The use of magnesium sulfate in the perioperative period has several benefits, including analgesia, inhibition of the release of catecholamines and prevention of vasospasm. The aim of this survey was to provide an overview of the use of magnesium sulfate in anesthesia. Method: This was a prospective descriptive cross-sectional study. An online questionnaire was sent to 9,869 Brazilian anesthesiologists and trainees. The questionnaire comprised closed questions mainly regarding the frequency, clinical effects, adverse events, and doses of magnesium sulfate used in anesthesia. Results: Of the 954 doctors who responded to the survey, 337 (35.32%) reported using magnesium sulfate in anesthesia. The most commonly cited clinical effects for the use of magnesium sulfate in anesthesia were ( n /%): postoperative analgesia (245/72.70%), reduction of anesthetic consumption (240/71.21%) and prevention and treatment of preeclampsia and seizures in eclampsia (220/65.28%). The most frequently reported adverse events were hypotension (187/55.48%), residual neuromuscular blockade (133/39.46%), hypermagnesemia (30/8.90%), and intravenous injection pain (26/7.71%). The intravenous doses of magnesium sulfate used in most general anesthesia inductions were between 30 and 40 mg.kg −1 . Conclusions: Magnesium sulfate is an important adjuvant drug in the practice of anesthesia, with several clinical effects and a low incidence of adverse events when used at recommended doses.

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“…[24] Prophylactic administration of anti-arrhythmic agents during the preoperative and the intraoperative period might also be an option. Lidocaine [121] and magnesium [122] are both used, and the latter seems to be more efficient. [123] Prophylactic use of β-blockers reduces the incidence of postoperative atrial fibrillation (POAF).…”

Section: Management Of Ischemiamentioning

confidence: 97%

Anesthesia for off-pump coronary artery bypass surgery

et al. 2013

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The evolution of techniques and knowledge of beating heart surgery has led anesthesia toward the development of new procedures and innovations to promote patient safety and ensure high standards of care. Off-pump coronary artery bypass (OPCAB) surgery has shown to have some advantages compared to on-pump cardiac surgery, particularly the reduction of postoperative complications including systemic inflammation, myocardial injury, and cerebral injury. Minimally invasive surgery for single vessel OPCAB through a limited thoracotomy incision can offer the advantage of further reduction of complications. The anesthesiologist has to deal with different issues, including hemodynamic instability and myocardial ischemia during aorto-coronary bypass grafting. The anesthesiologist and surgeon should collaborate and plan the best perioperative strategy to provide optimal care and ensure a rapid and complete recovery. The use of high thoracic epidural analgesia and fast-track anesthesia offers particular benefits in beating heart surgery. The excellent analgesia, the ability to reduce myocardial oxygen consumption, and the good hemodynamic stability make high thoracic epidural analgesia an interesting technique. New scenarios are entering in cardiac anesthesia: ultra-fast-track anesthesia with extubation in the operating room and awake surgery tend to be less invasive, but can only be performed on selected patients.

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Effects of preoperative magnesium therapy on arrhythmias and myocardial ischemia during off-pump coronary surgery

Cited by 5 publications

References 23 publications

Serum Magnesium Levels in Off - Pump Coronary Artery Bypass Grafting

Serum Magnesium Levels in Off - Pump Coronary Artery Bypass Grafting

Use Profile of Magnesium Sulfate in Anesthesia in Brazil

Anesthesia for off-pump coronary artery bypass surgery

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