Effects of propranolol on regional myocardial blood flow and function during severe coronary stenosis in dogs

Thuillez, Christian; Berdeaux, Alain; Bonhenry, C; Duhaze, P; Giudicelli, Jean‐François

doi:10.1016/0014-2999(83)90284-4

Cited by 11 publications

(1 citation statement)

References 15 publications

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“…Improvement of systolic function in post-stenotic myocardium was observed also after administration of a denitro derivative of nipradilol or propranolol, which lack the vasodilator property of nipradilol. These findings are in agreement with the previous studies that a P-adrenoceptor blocking agent(s) given during coronary stenosis exerted beneficial effects on the ischaemic myocardium in anaesthetized (Buck et al, 1979;Abiko & Sakai, 1980;Thuillez et al, 1983) and conscious dogs (Tomoike et al, 1978). Doses of all three agents employed in this study produced significant negative inotropic and chronotropic actions.…”

Section: Discussionsupporting

confidence: 93%

Effects of nipradilol on myocardial ischaemia produced by coronary stenosis in dogs

Noguchi

Sakanashi

1987

British J Pharmacology

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1 Effects of nipradilol which is a new P-adrenoceptor blocking agent endowed with nitroglycerinlike vasodilator actions, its denitrated derivative (denitro nipradilol) and propranolol on abnormalities of regional myocardial shortening produced by partial occlusion of the left circumflex coronary artery (LCX) were studied in anaesthetized open-chest dogs. 2 In the presence of LCX stenosis, nipradilol (0.1 mg kg-', i.v.) produced marked decreases in heart rate and LVdP/dt without a significant increase in left ventricular end-diastolic pressure (LVEDP). It improved impaired myocardial segment shortening and restored normal cardiac lactate metabolism. 3 Denitro nipradilol (0.2 mg kg-' i.v.) and propranolol (0.2 mg kg-' i.v.) both caused similar haemodynamic changes to nipradilol but also produced a significant increase in LVEDP. However, improvement by these two agents of regional dysfunction in the ischaemic myocardium was comparable to those seen with nipradilol. 4 All three agents markedly inhibited isoprenaline-induced tachycardia, but vehicle did not. 5 Atrial pacing abolished the beneficial effect of nipradilol on myocardial shortening in the ischaemic region without affecting other haemodynamic parameters. 6 These results indicate that nipradilol alleviates acute myocardial ischaemia produced by coronary stenosis with similar efficacy to denitro nipradilol and propranolol suggesting, that a major part of the beneficial effect of nipradilol may be attributable to its P-adrenoceptor blocking action.

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