Effects of Protein Supplementation Associated with Resistance Training on Body Composition and Muscle Strength in Older Adults: A Systematic Review of Systematic Reviews with Meta-analyses

Vieira, Alexandra; Santos, Juliana Souza; Costa, R. D. D.; Cadore, Eduardo Lusa; Macedo, Rodrigo Cauduro Oliveira

doi:10.1007/s40279-022-01704-0

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…Therefore, there is still a paucity of research on the effectiveness of MTN supplementation in middle-aged physically active adults. Additionally, given the potential benefits of protein supplementation alone to maximise-exercise induced outcomes, particularly lean body mass in older adults (Vieira et al 2022), studies comparing MTN vs. protein mono-component are necessary.…”

Section: Limitations and Recommendation For Future Studiesmentioning

confidence: 99%

No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: A systematic review and meta-analysis

Puente-Fernández

Larumbe-Zabala²,

Jiménez

et al. 2023

Experimental Gerontology

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Section: Limitations and Recommendation For Future Studiesmentioning

confidence: 99%

No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: A systematic review and meta-analysis

Puente-Fernández

Larumbe-Zabala²,

Jiménez

et al. 2023

Experimental Gerontology

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“…Aside from regular physical activity, nutritional interventions using nutrient supplements are targeted to prevent or postpone the onset of such geriatric conditions derived from sarcopenia [32,40,41]. Especially, a high-protein diet or protein supplementation is believed to have surplus benefits in augmenting efficacy of RT for healthy older people [42][43][44][45], as well as those who have high risks of sarcopenia [41,[43][44][45][46][47][48][49][50][51]. Sufficient protein intake plays a key role to stimulate maximal rate of muscle protein synthesis leading to anabolism and net new muscle protein accretion during RT [52,53].…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Different Protein Supplements on Muscle Mass, Strength, and Physical Indices of Sarcopenia among Community-Dwelling, Hospitalized or Institutionalized Older Adults Undergoing Resistance Training: A Network Meta-Analysis of Randomized Controlled Trials

Liao,

Huang,

Chen

et al. 2024

Nutrients

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Aging-related sarcopenia exerts harmful impacts on muscle mass, strength, and physical mobility. Protein supplementation has been demonstrated to augment efficacy of resistance training (RT) in elderly. This study compared the relative effects of different protein supplements on muscle mass, strength, and mobility outcomes in middle-aged and older individuals undergoing RT. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) examining the efficacy of protein supplement plus RT in untrained community-dwelling adults, hospitalized, or institutionalized residents who suffered acute or chronic health conditions. Network meta-analysis (NMA) was performed using a frequentist method for all analyses. Treatment effects for main outcomes were expressed as standard mean difference (SMD) with 95% confidence interval (CI). We used the surface-under-the cumulative-ranking (SUCRA) scores to rank probabilities of effect estimation among all identified treatments. Meta-regression analyses were performed to identify any relevant moderator of the treatment efficacy and results were expressed as β with 95% credible interval (CrI). We finally included 78 RCTs (5272 participants) for analyses. Among the six protein sources identified in this NMA, namely whey, milk, casein, meat, soy, and peanut, whey supplement yielded the most effective treatments augmenting efficacy of RT on muscle mass (SMD = 1.29, 95% CI: 0.96, 1.62; SUCRA = 0.86), handgrip strength (SMD = 1.46, 95% CI: 0.92, 2.00; SUCRA = 0.85), and walking speed (SMD = 0.73, 95% CI: 0.39, 1.07; SUCRA = 0.84). Participant’s health condition, sex, and supplementation dose were significant factors moderating the treatment efficacy on muscle mass (β = 0.74; 95% CrI: 0.22, 1.25), handgrip strength (β = −1.72; 95% CrI: −2.68, −0.77), and leg strength (β = 0.76; 95% CrI: 0.06, 1.47), respectively. Our findings suggest whey protein yields the optimal supplements to counter sarcopenia in older individuals undergoing RT.

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Enhancing health outcomes in institutionalized older adults: The critical role of combined exercise and nutritional interventions

Cadore,

Izquierdo

2024

The Journal of nutrition, health and aging

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Effects of Protein Supplementation Associated with Resistance Training on Body Composition and Muscle Strength in Older Adults: A Systematic Review of Systematic Reviews with Meta-analyses

Cited by 6 publications

References 40 publications

No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: A systematic review and meta-analysis

No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: A systematic review and meta-analysis

Comparative Efficacy of Different Protein Supplements on Muscle Mass, Strength, and Physical Indices of Sarcopenia among Community-Dwelling, Hospitalized or Institutionalized Older Adults Undergoing Resistance Training: A Network Meta-Analysis of Randomized Controlled Trials

Enhancing health outcomes in institutionalized older adults: The critical role of combined exercise and nutritional interventions

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