Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats

Riezen, H. van; Leonard, Brian E.

doi:10.1016/0163-7258(90)90043-2

Cited by 194 publications

(66 citation statements)

References 79 publications

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“…An exaggeration of locomotor activity in OBX animals was observed compared with sham rats when placed in a high illuminated open-field ( Figure 6). This is consistent with previous reports and is believed to be due to a deficit of habituation to a new stressful environment (Cairncross et al 1979;Van Riezen and Leonard, 1990;McNish and Davis, 1997;Song and Leonard, 2005;Romeas et al, 2009). Importantly, although fluoxetine was ineffective after a 7-day treatment (as expected for an SSRI; Lucas et al, 2007;Breuer et al, 2007), SB-269970 reversed the OBXinduced hyperactivity.…”

Section: Discussionsupporting

confidence: 81%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

130

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Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT 7 ) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT 7 receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT 7 receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT 7 receptor antagonists may represent a new class of antidepressants with faster therapeutic action.

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Section: Discussionsupporting

confidence: 81%

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Mnie-Filali

Faure

Lambás‐Señas

et al. 2011

Neuropsychopharmacol

130

View full text Add to dashboard Cite

show abstract

“…OB is not only a primary center of olfaction but also a ruler of emotions and learning in animals (Ueki et al, 1972;Leonard, 1984;Durand et al, 1998). It was reported that olfactory bulbectomy caused imbalances in brain neurotransmitters, including noradrenalin, dopamine and serotonin (Edwards et al, 1977;Song and Leonard, 2005), and also caused marked and sustained hyperactivity in rats (van Riezen and Leonard, 1990). Taken together, this information and the present results, it is possible that a small amount of NRDEP enhanced spontaneous activity of the animals through its proinflammatory activity on OB.…”

Section: Discussionsupporting

confidence: 72%

Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

Yokota¹,

Takashima²,

Ohta

et al. 2011

J. Toxicol. Sci.

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-In the present study, in order to reveal novel adverse effects of ultrafine particles (UFP) on the central nervous system, the effects of nanoparticle-rich diesel exhaust particles (NRDEP; count mode diameter, 21.45 nm) on emotional behavior, learning capability and brain neurotransmitter levels were studied in rats by intranasal instillation (iNI). NRDEP (10 and 50 μg/rat) was instilled into 2-week old infant, male rats once a week for 4 weeks. Spontaneous motor activity measured was observed to be inverse to the dose level. In active avoidance tests using a shuttle box, NRDEP-treated animals showed a lower avoidance performance than control animals given air-instillation. The levels of dopamine and its metabolite (DOPAC) in the medial mammillary nucleus of the brain tended to be lower in the NRDEPtreated animals. From these results, although the effects of NRDEP by iNI on the emotionality and the brain neurotransmitter levels were not fully clear, the results obtained by avoidance testing suggested involvement of UFP in learning capability.

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“…The olfactory bulbectomy (OBX) rat model is considered to be one of the best animal models of depression because of its complex constellation of behavioral, neurochemical, neuroendocrine and neuroimmune alterations; similar to those reported in patients with major depression [11,12,33]. OBX has been shown to be sensitive to chronic, but not acute, administration of clinically efficacious antidepressants [6,33].…”

Section: Introductionmentioning

confidence: 92%

“…OBX has been shown to be sensitive to chronic, but not acute, administration of clinically efficacious antidepressants [6,33]. In addition, this model does not rely on selectively bred animals and can therefore provide a method to investigate the interaction between genetic susceptibility and environmental factors in different inbred strains of rats.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression

Vieyra-Reyes¹,

Mineur²,

Picciotto³

et al. 2008

Brain Research Bulletin

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In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore, we compared the antidepressant-like effects of nicotine on Wistar rats to those of transcranial magnetic stimulation (TMS), which has emerged as a therapeutic alternative for depression management.Our results show that Wistar rats develop depression-like symptoms, demonstrated by the forced swim test (FST), four weeks after OBX. However, we cannot observe these symptoms in bulbectomized Long Evans rats. Our results suggest that there are some innate differences in susceptibility to stress between these two rat strains.In Wistar rats, voluntary oral nicotine intake (1.2 mg/kg/day for 14 days) as well as nicotine administered as a single daily i.p. injection (1.5 mg/kg/day for 14 days) decrease the depression-like symptoms of OBX. Daily transcranial magnetic stimulation (TMS; 60 Hz and 0.7 mT for two hours per day for 14 days) also decreases depression-like symptoms but is less effective than nicotine.In conclusion, our results support the idea that there are possible innate differences for depression susceptibility and that nicotine and TMS may be useful in the treatment of this syndrome.

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Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats

Cited by 194 publications

References 79 publications

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression

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