Effects of PTTG Down-regulation on Proliferation and Metastasis of the SCL-1 Cutaneous Squamous Cell Carcinoma Cell Line

Xia, Yonghua; Li, Min; Fu, Dandan; Xu, Suling; Li, Zhanguo; Liu, Dong; Tian, Zhongmin

doi:10.7314/apjcp.2013.14.11.6245

Cited by 11 publications

(10 citation statements)

References 27 publications

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“…Thus, it is well established that the degradation of ECM and basement membrane, which requires a wide range of proteolytic enzymes, enhance the ability of tumor cells to invade and metastasize. MMPs play an important role in this process and as they have been implicated in the degradation of ECM and basement membrane [ 60 , 63 ] ( Figure 4 and Figure 5 ).…”

Section: Photocarcinogenesismentioning

confidence: 99%

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Pittayapruek

Meephansan

Prapapan

et al. 2016

IJMS

809

666

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Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases with an extensive range of substrate specificities. Collectively, these enzymes are able to degrade various components of extracellular matrix (ECM) proteins. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, and MMP-16). The alterations made to the ECM by MMPs might contribute in skin wrinkling, a characteristic of premature skin aging. In photocarcinogenesis, degradation of ECM is the initial step towards tumor cell invasion, to invade both the basement membrane and the surrounding stroma that mainly comprises fibrillar collagens. Additionally, MMPs are involved in angiogenesis, which promotes cancer cell growth and migration. In this review, we focus on the present knowledge about premature skin aging and skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, with our main focus on members of the MMP family and their functions.

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Section: Photocarcinogenesismentioning

confidence: 99%

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Pittayapruek

Meephansan

Prapapan

et al. 2016

IJMS

809

666

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“…In America, > 2 million cases of BCC and SCC are diagnosed yearly, caused mainly by cumulative exposure to ultraviolet (UV) light 1,2 . Surgical excision, radiation therapy, and chemotherapy are some of the common methods employed in the treatment of BCC and SCC.…”

Section: Introductionmentioning

confidence: 99%

Topical calcitriol prior to photodynamic therapy enhances treatment efficacy in non-melanoma skin cancer mouse models

2015

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Non-melanoma skin cancers (NMSCs) such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common form of human cancer worldwide, and their incidence is increasing. Photodynamic therapy (PDT), mediated by topically applied aminolevulinic acid (ALA) and subsequent exposure to light (either a laser or a noncoherent source), is being increasingly used for the treatment of dermatological disorders, including BCC and SCC. However, therapeutic responses of NMSCs to ALA-PDT are currently not superior to standard therapies, although the latter have undesirable side effects including scarring. In this study, we report that preconditioning of skin tumors with calcitriol (active form of Vitamin D; Vit D) prior to ALA-PDT, significantly improves the treatment outcome. In BCC and UVB-induced SCC mouse models, we identified an increase in tumor-specific accumulation of ALA induced photosensitizer (protoporphyrin IX, PpIX) due to Vit D preconditioning, of up to 6-fold in vivo. In addition, increased expression of differentiation (145 fold, p < 0.02) and proliferation (42 fold, p < 0.005) markers were identified in BCC tumors, all leading to increased tumor destruction (18.3 fold, p < 0.03) with the combination approach, as compared to ALA-PDT alone. Histomorphological changes identified using hematoxylin and eosin staining, and results of TUNEL staining, together documented a beneficial effect of Vit D pretreatment upon tumor cell death. We conclude that this new combination approach with Vit D and ALA-PDT has great potential to achieve complete remission of NMSC tumors, with excellent cosmetic results and an overall beneficial impact upon patient care.

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“…In HEK293 cells, transfection with PTTG cDNA significantly increased the secretion and expression of MMP2 (25). Furthermore, in a cutaneous squamous cell carcinoma cell line, the downregulation of PTTG by small interfering RNA (siRNA) significantly inhibited proliferation and metastasis, and decreased the expression of MMP2 and MMP9 (26). These findings indicate a positive correlation between securin and MMPs.…”

Section: Introductionmentioning

confidence: 59%

Securin promotes migration and invasion via matrix metalloproteinases in glioma cells

et al. 2015

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Abstract. Human securin, encoded by pituitary tumor transforming gene 1, is implicated in several oncogenic processes in the pathogenesis of brain tumors, including glioma. The aim of the present study was to examine the effect of securin on the migration and invasion of glioma cells. The results revealed that the overexpression of securin in glioma LN-229 cells significantly increased the invasion and transmigration abilities. By contrast, these abilities were significantly reduced by the downregulation of securin in glioma U373 cells. Furthermore, the results demonstrated that securin overexpression and downregulation significantly increased and decreased the levels of matrix metalloproteinase 2 and 9, respectively. These findings indicate a promotive role for securin in glioma migration and invasion, which may involve the action of matrix metalloproteinases.

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Effects of PTTG Down-regulation on Proliferation and Metastasis of the SCL-1 Cutaneous Squamous Cell Carcinoma Cell Line

Cited by 11 publications

References 27 publications

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

Topical calcitriol prior to photodynamic therapy enhances treatment efficacy in non-melanoma skin cancer mouse models

Securin promotes migration and invasion via matrix metalloproteinases in glioma cells

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