Effects of Puffed and Fermented Red Ginseng on Blood Glucose-related Biomarkers in Streptozotocin-Induced Diabetic Rats

박주헌,; 성기승,; 김성수,; 심건섭,; 한찬규,

doi:10.3746/jkfn.2012.41.5.630

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…최근 경제성장과 더불어 국민소득이 증대됨에 따라 식생활 패턴의 서구화로 당뇨병, 비만, 고지혈증, 동맥경화증 및 고 혈압과 같은 생활습관성 대사증후군에 노출되고 있다 [1][2][3] . 이 중 당질대사 이상을 초래하는 당뇨병은 인슐린의 절대적 또는 상대적 결핍으로 인하여 발생되는 고혈당 상태 및 이에 수반 되는 대사 장애가 장기간 지속되는 상태가 특징이며, 혈관장 애, 망막증, 신증, 신경장애, 감염증 등이 당뇨합병증으로 나 타날 수 있다 1,4) .…”

Section: 서 론 1)unclassified

The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin-induced diabetes in rats

Han

Park²

2013

The Korea Journal of Herbology

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Objectives : This study aimed to compare the anti-diabetic efficacy of Lycii Radicis Cortex (Lycium chinense Mill.) and Corni Fructus (Cornus officinalis) on streptozotocin (STZ)-induced diabetes in rats.Methods : Male Sprague-Dawley rats were divided into four groups; normal, STZ-control, Lycii Radicis Cortex extract-administrated group (LRC) and Corni Fructus extract-administrated group(CF). Diabetes in rats was induced by intraperitonal injection with streptozotocin (STZ) at doses of, 30 ㎎/㎏ (body weight) for 5 days (once per a day). STZ-induced diabetic rats were orally administrated LRC and CF extract daily for 4 weeks at doses of 300 ㎎/㎏. Fasting blood glucose, total cholesterol (TC), triglyceride (TG), blood urea nitrogen (BUN) and creatinine were measured in sera of rats. Histopathological changes of kidney, liver and lung tissues were observed by microscope after H&E staining. Results : There were no differences in body and kidney weights, food intake and water intake in LRC-and CF-administrated groups compared with STZ control group. However, glucose, TC and TG levels in serum were significantly decreased in LRC-administrated groups compared with STZ-control group. In histopathological analysis of kidney, liver and lung, both LRC-and CF-administrated groups showed the inhibition of morphological damage. Conclusions : These results suggest that LRC and CF have a biological action on STZ-induced diabetes in rats via decreasing the serum TG and TG levels and may protect the morphological changes of kidney, liver and lung.

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Section: 서 론 1)unclassified

The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin-induced diabetes in rats

Han

Park²

2013

The Korea Journal of Herbology

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The effects of ginseng on the metabolic syndrome: An updated review

Aminifard

Razavi

Hosseinzadeh

2021

Food Science & Nutrition

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Metabolic syndrome or syndrome X is the name given to the collection of clinical conditions including overweight, high blood pressure, high blood glucose (or type 2 diabetes mellitus), and hyperlipidemia (Chen et al., 2017).Metabolic syndrome is the most important risk factor for atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction. Metabolic syndrome increases the risk of cardiovascular diseases. Cardiovascular diseases are the main reasons for mortality around the world . The metabolic syndrome is rising due to a sedentary lifestyle. Children, adolescents, and young women with polycystic ovary syndrome are at risk for metabolic syndrome (Vassallo et al., 2016).Medicine herbs, because of their potential efficacy in improving and holding human health, low cost, and adverse effects, have been the focus of attention. Studies have been shown that several plants and their active constituents can exert beneficial effects on metabolic syndrome. For example, grapes (Vitis vinifera), a source of polyphenol antioxidants, is useful for preventing the risk factors involved in metabolic syndromes such as hyperlipidemia, hypertension, and hyperglycemia (Akaberi & Hosseinzadeh, 2016). Garlic (Allium sativum) has been documented in the treatment of metabolic syndrome as it showed hypoglycemic, hypotensive, and hypolipidemic activities (Hosseini & Hosseinzadeh, 2015). Rosemary (Rosmarinus officinalis L.) is a source of phenolic phytochemicals having considerable anti-inflammatory, antioxidant, hypoglycemic, hypolipidemic, and hypotensive effects (Hassani et al., 2016).

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Anti-diabetic effects of Allium tuberosum rottler extracts and lactic acid bacteria fermented extracts in type 2 diabetic mice model

Kim¹,

Jo²,

Jeong³

et al. 2015

Korean Journal of Food Preservation

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The anti-diabetic effects of Allium tuberosum Rottler extracts (ATE) and ATE fermented with lactic acid bacteria in db/db mice were evaluated. The electron donating activity of ATE fermented with Lactobacillus plantarum, and Lactobacillus casei, respectively, increased compared to that of ATE, but the superoxide radical scavenging activity of the ATE incubated with L. plantarum decreased. The superoxide radical scavenging activity of the ATE fermented with both L. plantarum and L. casei was similar to that of the ATE. Therefore, fermented ATE (FATE) was prepared for in vivo testing by incubating it with both L. plantarum and L. casei. The db/db mice were divided into six groups: normal (non-diabetic mice), diabetic control (DM), and four experimental groups administered 200 or 400 mg/kg/day ATE (ATE200 and ATE400) and 200 or 400 mg/kg/day FATE (FATE200 and FATE400). Weight gain was significantly inhibited in the FATE200 group compared with that in the other db/db mice groups (p<0.05). The areas under the curve of the ATE400 and FATE400 groups were significantly smaller than that of the DM group in the glucose tolerance evaluation. The serum glucagon-like peptide-1 levels in the ATE400 and FATE400 groups increased. These results indicate that administering ATE and FATE may be effective against anti-hyperglycemia by regulating insulin resistance. In particular, FATE may be beneficial for controlling obesity in type 2 diabetes. Key words：Allium tuberosum rottler, db/db mouse, oral glucose tolerance test, insulin resistance, type 2 diabetes mellitus 서 론

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Effects of Puffed and Fermented Red Ginseng on Blood Glucose-related Biomarkers in Streptozotocin-Induced Diabetic Rats

Cited by 5 publications

References 29 publications

The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin-induced diabetes in rats

The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin-induced diabetes in rats

The effects of ginseng on the metabolic syndrome: An updated review

Anti-diabetic effects of Allium tuberosum rottler extracts and lactic acid bacteria fermented extracts in type 2 diabetic mice model

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