Effects of Qijian mixture on type 2 diabetes assessed by metabonomics, gut microbiota and network pharmacology

Gao, Kuo; Yang, Ran; Zhang, Jian; Wang, Zhiyong; Jia, Caixia; Zhang, Feilong; Li, Shaojing; Wang, Jinping; Murtaza, Ghulam; Xie, Hua; Zhao, Huihui; Wang, Wei; Chen, Jianxin

doi:10.1016/j.phrs.2018.01.011

Cited by 99 publications

(59 citation statements)

References 55 publications

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“…Traditional Chinese medicine (TCM) has a long history of use for the prevention and treatment of diabetes. Recently, much evidence-based medical data has confirmed the curative effect of TCM on diabetes and associated complications (Liu Q. et al, 2017;Gao et al, 2018;Nie et al, 2019;Xiang et al, 2019). TCM Herbal formulations are guided by the principles of compatibility and of "monarch, minister, assistant, and guide, " which are applied when deciding which combination of herbs will achieve the desired effect in treating the disease (Ma et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

A Novel Antidiabetic Monomers Combination Alleviates Insulin Resistance Through Bacteria-Cometabolism-Inflammation Responses

et al. 2020

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The present study sought to examine the therapeutic effect of a novel antidiabetic monomer combination (AMC) in treating type 2 diabetes mellitus (T2DM); while also elucidating the potential functional mechanism. Male C57BL/6J mice were fed a highfat diet (HFD) for 12 weeks to establish T2DM. The AMC group showed significant reduction in weight, fasting blood glucose (FBG), serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), and experienced reduced insulin resistance based on oral glucose tolerance testing (OGTT) and hyperinsulinemic-euglycemic clamp testing ("gold standard" for determining in vivo insulin sensitivity). Further, AMC restored the altered intestinal flora by increasing the abundance of the beneficial bacteria Akkermansia, and decreasing the number of harmful bacteria, including Bacteroides, Odoribacter, Prevotella 9, Alistipes, and Parabacteroides. Components of the hostmicrobial metabolome were also significantly changed in the AMC group compared to the HFD group, including hydroxyphenyllactic acid, palmitoleic acid, dodecanoic acid, linoleic acid, and erucic acid. Furthermore, AMC was found to inhibit inflammation and suppress signaling pathways related to insulin resistance. Lastly, spearman correlation analysis revealed relationships between altered microbial community and co-metabolite levels, co-metabolites and inflammatory cytokines. Hence, the potential mechanism responsible for AMC-mediated alleviation of insulin resistance was suggested to be involved in modulation of bacteria-cometabolism-inflammation responses.

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Section: Introductionmentioning

confidence: 99%

A Novel Antidiabetic Monomers Combination Alleviates Insulin Resistance Through Bacteria-Cometabolism-Inflammation Responses

et al. 2020

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“…72 Increased Bacteroidetes to Firmicutes has also shown after intervention with Qijian mixture (Astragalus membranaceus, Ramulus euonymi, Coptis chinensis, and Pueraria lobata) and extract of D. loddigesii. 73,74 Increased abundance of Akkermansia was also associated with glucose-lowering properties of polyphenolrich extracts of cranberry. 75 Water-ethanol extract of green macroalgae Enteromorpha prolifera and Oil tea (green tea and ginger) enriched Lachnospiraceae has been reported after intake of in animal studies, 76,77 wherein it was suggested to underlie its beneficial impact on glycemic control.…”

Section: Herbal Agents Used To Treat T2d and Gut Microbiotamentioning

confidence: 99%

Considering gut microbiota in treatment of type 2 diabetes mellitus

2020

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Advances in the understanding of the pathogenesis of type 2 diabetes mellitus (T2D) have revealed a role for gut microbiota dysbiosis in driving this disease. This suggests the possibility that approaches to restore a healthy host-microbiota relationship might be a means of ameliorating T2D. Indeed, recent studies indicate that many currently used treatments for T2D are reported to impact gut microbiota composition. Such changes in gut microbiota may mediate and/or reflect the efficacy of these interventions. This article outlines the rationale for considering the microbiota as a central determent of development of T2D and, moreover, reviews evidence that impacting microbiota might be germane to amelioration of T2D, both in terms of understanding mechanisms that mediate efficacy of exiting T2D therapies and in developing novel treatments for this disorder. ARTICLE HISTORY

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“…e topological analysis was further carried out on the nodes in the C-T network of CSCC using the calculations of Cytoscape's NetworkAnalyzer tool on the main topological features (degree, betweenness centrality, average shortest-path length, and closeness centrality) [27,28]. A major C-T network of CSCC was established with node degrees higher than an average node degree value of 5.022; the detailed information is shown in Figure 3(b).…”

Section: Network Topological Analysismentioning

confidence: 99%

Integrating Pharmacology and Microbial Network Analysis with Experimental Validation to Reveal the Mechanism of Composite Sophora Colon‐Soluble Capsule against Ulcerative Colitis

Ding

Chen

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Ulcerative colitis (UC) has multifactorial pathogenesis that acts synergistically, such as immune system dysregulation and expansion of infectious gut microbiota. Therefore, a multicomponent treatment derived from Chinese herbal medicine that interacts with multiple targets synergistically is needed. Composite sophora colon-soluble capsule (CSCC) is a Chinese herbal formula that has shown therapeutic efficacy against UC in randomized clinical trials. However, its bioactive components and potential target genes against UC remain unclear. Here, we used a network pharmacology approach to detect component-target-pathway interactions of CSCC against UC. A total of 29 gene targets, 91 bioactive components, and 20 enriched pathways of CSCC were identified. The IL-17 signaling pathway activated by infectious gastrointestinal microbes and predicted by the network analysis to be a major pathway modulated by CSCC against UC was studied in a dextran sulfate sodium-induced colitis model. CSCC showed remarkable efficacy against UC with respect to the attenuation of colon length, body weight loss, and disease activity index through gut microbiota recovery and intestinal immune homeostasis. The rectal administration of CSCC reduced the numbers of Th17 cells isolated from both mesenteric lymph nodes and lamina propria mononuclear cells and the levels of IL-17A, IL-6, IL-1β, and TNF-α. Additionally, the percentage of Treg cells and the levels of their hallmark cytokines were upregulated. Rectal administration of CSCC led to microbiota regulation with a significant correlation between suppression of Verrucomicrobiaceae and Ruminococcaceae, as well as the elevation of Lactobacillaceae, and CSCC administration via microbiome correlation heatmaps and cooccurrence network analysis at multiple time points. Thus, our study presents an effective herbal formula, CSCC, for UC treatment and explores its components and mechanisms of efficacy through the examination of gut microbiota and hallmark cytokines in the IL-17 pathway.

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Effects of Qijian mixture on type 2 diabetes assessed by metabonomics, gut microbiota and network pharmacology

Cited by 99 publications

References 55 publications

A Novel Antidiabetic Monomers Combination Alleviates Insulin Resistance Through Bacteria-Cometabolism-Inflammation Responses

A Novel Antidiabetic Monomers Combination Alleviates Insulin Resistance Through Bacteria-Cometabolism-Inflammation Responses

Considering gut microbiota in treatment of type 2 diabetes mellitus

Integrating Pharmacology and Microbial Network Analysis with Experimental Validation to Reveal the Mechanism of Composite Sophora Colon‐Soluble Capsule against Ulcerative Colitis

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