Effects of Reserpine on the Incidence of 9,10-Dimethyl-1,2-benzanthracene-induced Tumors in Pinealectomised and Thymectomised Rats

Lapin, V.

doi:10.1159/000225271

Cited by 16 publications

(5 citation statements)

References 9 publications

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“…In contrast to catecholamine stimulation, treatments that reduce catecholamine activity may enhance tumor growth. Treatment with reserpine, which reduced central amine levels, exacerbated both DMBA-induced and spontaneous mammary tumors (Lacassagne & Duplan, 1959;Lapin, 1978;Welsch & Meites, 1970). Likewise, we found that depletion of DA and NE by a-methyl-p-tyrosine enhanced the development of a transplanted P815 mastocytoma (Sklar & Anisman,Note 2).…”

Section: Neurochemical Changes In Stress-induced Tumorigenesissupporting

confidence: 56%

Stress and cancer.

Sklar¹,

Anisman²

1981

Psychological Bulletin

320

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Consistent with the findings of human research suggesting that stress may influence the carcinogenic process, data derived from infrahuman experimentation have revealed that aversive insults may potentiate or inhibit tumorigenicity. The nature of the change, however, is dependent on a number of psychological, experiential, and organismic variables. Exacerbation of tumor growth is evident following acute exposure to uncontrollable, but not controllable, stress. Moreover, the effects of aversive stimuli vary as a function of the organism's prior stress history as well of social housing conditions. The fact that stress influences neurochemical, hormonal, and immunological functioning and that these changes are subject to many of the same manipulations that influenced the carcinogenic process suggests a relation between these three mechanisms and the stress-induced alterations of tumor growth. This contention is supported by the findings that pharmacological manipulations that modify these endogenous substrates have predictable effects on tumorigenesis.

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Section: Neurochemical Changes In Stress-induced Tumorigenesissupporting

confidence: 56%

Stress and cancer.

Sklar¹,

Anisman²

1981

Psychological Bulletin

320

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“…DMBA tumour incidence and tumour progression is significantly higher in pinealectomized rats than in intact ones, both treated with the serotonin-antagonist reserpine (Lapin, 1978). Serotonin administration has an inverse effect on transplantable tumours (Lapin and Frowein, in preparation), tumour growth inhibition being significantly more pronounced in pinealectomized rats than in intact rats.…”

Section: The Significance Of Biogenic Monoarnines and The Hypothalarnmentioning

confidence: 97%

“…Experimental as well as clinical data have shown that the growth of neoplasms can be influenced by the pineal gland and its compounds (Lapin, 1976(Lapin, , 1978Lapin and Frowein, in preparation;Tapp, 1980 a, b). This may, however, be due to various mechanisms including endccrine activities of the pineal.…”

Section: The Significance Of Biogenic Monoarnines and The Hypothalarnmentioning

confidence: 99%

The role of the pineal gland in neuroendocrine control mechanisms of neoplastic growth

Lapin

Ebels

1981

J. Neural Transmission

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A survey of papers read during a workshop held in Vienna, 1977, is given showing that the pineal gland can be considered a model for research on neuroendocrine control mechanisms in neoplastic growth. From data obtained by different authors it can be concluded that the role of the pineal indole melatonin is very important in regard of the incidence and the development of tumours. On the basis of all the facts mentioned in this paper it is obvious that pineal gland activity should be included into the neuroendocrine factors studied in relation with oncogenic processes. For future research a number of experimental approaches, which need special emphasis, are recommended.

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“…They concluded that this observation may be important for the diagnosis and control of malignancy. Lapin (1978) observed that, a~er treatment with the tranquilizer reserpine, the incidence of dimethylbenzanthracene (DMBA)-induced tumours was found to be significantly higher in pinealectomized than in intact or th'ymectomized ones. A very high rate of DMBA-leukemia was observed in immune deficient pinealectomized rats a~er reserpine administration.…”

Section: * I Ebelsmentioning

confidence: 99%

“…It may be that the results of Lapin (1978) can be explained by an interaction of reserpine with pteridine metabolism and that the pineal can influence that interaction in some way. Therefore, the study of pteridine metabolism in relation to the pineal and tumour growth may develop into a very interesting field of research in the future.…”

Section: * I Ebelsmentioning

confidence: 99%

A survey of the location, isolation and identification of indoles, pteridines and some unknown active substances in sheep pineals. The possible significance of pteridines for the neuroendocrine control of neoplastic growth

Ebels

1980

J. Neural Transmission

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Several indoles with mass spectra identical to those of synthetic melatonin, 5-hydroxyindole-3-acetic acid (5-HIAA), 5-methoxyindole-3-acetic acid (5-MIAA), 5-hydroxytryptophol (5-HTL) and 5-methoxytryptophol (5-MTL) could be located, isolated and identified in sheep pineal extracts using rather simple and mild extraction and separation methods. An antigonadotropin, which differs from melatonin, was isolated and partially purified from sheep pineals, using compensatory ovarian hypertrophy after unilateral ovariectomy as a bioassay. Antigonadotropic and gonadotropic compounds which differ from the indoles above mentioned could be located with the same methods. In vitro, these fractions act either on the hypothalamus or on the anterior pituitary. From the paper chromatography fraction, acting on the anterior pituitary in vitro, a compound could be isolated which is most probably identical with biopterin. In our opinion, however, this compound is not responsible for the antigonadotropic activity of the fraction, observed in vitro. Some pineal fractions showing an effect on the activity of the hypothalamus or anterior pituitary of male rats and mice in vitro, may be also active in some experimental tumour models. A possible relationship between disorders in pteridine metabolism and neoplastic growth is discussed.

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Effects of Reserpine on the Incidence of 9,10-Dimethyl-1,2-benzanthracene-induced Tumors in Pinealectomised and Thymectomised Rats

Cited by 16 publications

References 9 publications

Stress and cancer.

Stress and cancer.

The role of the pineal gland in neuroendocrine control mechanisms of neoplastic growth

A survey of the location, isolation and identification of indoles, pteridines and some unknown active substances in sheep pineals. The possible significance of pteridines for the neuroendocrine control of neoplastic growth

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