Effects of resistance exercise training on acyl-ghrelin and obestatin levels in hemodialysis patients

Moraes, Cristiane; Marinho, Sandra Mara; Lobo, Julie Calixto; Stockler‐Pinto, Milena Barcza; Barros, Amanda F.; Jacobson, Ludmilla Viana; Nóbrega, Antônio Cláudio Lucas da; Rosa, Maria Luiza Garcia; Mafra, Denise

doi:10.3109/0886022x.2015.1033634

Cited by 17 publications

(25 citation statements)

References 28 publications

(36 reference statements)

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“…Our study also showed that high‐sensitivity C‐reactive protein (hs‐CRP), as a marker of chronic inflammation in dialysis patients, did not undergo significant changes after 12 weeks of physical exercise. The selection of hs‐CRP as a marker of inflammation in our study was due to its strong correlation with cardiovascular prognostic factors . In addition, hs‐CRP has a long half‐life and is independent of other factors .…”

Section: Discussionmentioning

confidence: 99%

“…The selection of hs-CRP as a marker of inflammation in our study was due to its strong correlation with cardiovascular prognostic factors. 28 In addition, hs-CRP has a long half-life and is independent of other factors. 29 However, our study showed that the hs-CRP level of the subjects had a wide range of variation, which may hinder the analysis between groups.…”

Section: Discussionmentioning

confidence: 99%

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The effect of intradialytic exercise twice a week on the physical capacity, inflammation, and nutritional status of dialysis patients: A randomized controlled trial

Suhardjono

Umami

Tedjasukmana

et al. 2019

Hemodialysis International

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Introduction: Inactivity, uremia, and malnutrition in dialysis patients may lead to decreased muscle mass and physical capacity. As a preventative measure, dialysis patients are provided with an intradialytic exercise program. Our study aimed to determine the role of intradialytic exercise performed 2 times per week on physical capacity, inflammation, and nutritional status in dialysis patients and to determine which exercises are more suitable for this population. Methods: A randomized clinical trial in which participants were randomly assigned to 1 of 3 groups, i.e., a group of patients performing aerobic exercise, a group of patients performing a combination of aerobic and resistance exercise and the control group. The study was conducted at the Dialysis Unit of Dr. Cipto Mangunkusumo General Hospital, Jakarta for 12 weeks from February to May 2018. The inclusion criteria were dialysis patients aged over 18 years who had undergone routine dialysis for over 3 months. Findings: A total of one hundred twenty patients were included in the study. There was a significant increase in lower extremity strength in the group performing aerobic exercise and in the combined exercise group compared to the lower extremity strength of the control group. There was also a significant increase in the physical component score (PCS) of the KDQOL‐SF™ instrument in the aerobic training and combination exercise groups compared to the PCS of the control group. No significant differences were found between the combination exercise group and the aerobic training group in any outcome. Discussion: Both types of exercise programs significantly increased the lower extremity muscle strength and the PCS of the quality of life index. Combination exercise was not more effective than aerobic exercise for dialysis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of intradialytic exercise twice a week on the physical capacity, inflammation, and nutritional status of dialysis patients: A randomized controlled trial

Suhardjono

Umami

Tedjasukmana

et al. 2019

Hemodialysis International

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“…Obestatin decreased and acyl-ghrelin increased significantly among patients of the exercise group. 8 A study with obese/overweight women showed no effect of moderate intensity acute exercise (running at 50% of VO2 max ) on obestatin levels. 30 A single circuit-resistance exercise had no effect on plasma obestatin levels in female college students; however, the authors reported that GH levels increased significantly and concluded that obestatin, likewise acyl-ghrelin, does not contribute to circuit-resistance exercise-induced increase in GH.…”

Section: Discussionmentioning

confidence: 99%

“…A study of our group showed that 6 months of resistance exercise in hemodialysis (HD) patients was effective in reducing obestatin and increasing acyl-ghrelin levels. 8 However, the effects of acute exercise on appetite hormones levels were not evaluated in CKD patients. Then, the objective of this study was evaluating the effects of a single bout of resistance exercise on acyl-ghrelin and obestatin plasma levels of CKD patients undergoing HD.…”

Section: Introductionmentioning

confidence: 99%

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

et al. 2015

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Chronic physical exercises may be beneficial to modulate appetite hormones as acyl-ghrelin (orexigenic) and obestatin (anorexigenic) in chronic kidney disease (CKD) patients; however, there are no data about the effects of acute exercises on these hormones. Thus, the aim of the present study was to assess the effect of acute resistance exercise on appetite hormones (acylghrelin and obestatin) of patients undergoing hemodialysis (HD). Twenty-five patients (44.7 ± 12.9 years, 68% women) on regular HD program were enrolled into two groups, 16 patients performed exercises and 9 patients comprised the control group. The patients performed the exercises in both lower limbs with ankle-cuffs and elastic bands, 30 min after the initiation of hemodialysis session. Blood samples of both the groups were drawn in the morning before and after 30 min with exercise session (exercise group) and, before and after the same time without exercise (control group). Acyl-ghrelin and obestatin plasma levels were measured using an enzyme immunometric assay. Acyl-ghrelin plasma levels did not change in both the groups. However, when stratified by gender the acyl-ghrelin increased significantly right after exercise in men [32.1 pg/mL (25.6-41.2) to 46.0 pg/mL (39.0-59.5)] (p ¼ 0.04). Obestatin plasma levels reduced after a single bout of exercise and changes remained significantly when the sample was stratified by gender. There was no change in obestatin plasma levels in control group. A single bout of resistance exercise seems to modulate the levels of appetite hormones in HD patients.

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“…Moraes et al [58] reported that acyl-ghrelin increased after a six month of resistance exercises in hemodialyresistance exercises in hemodialysis patients. Martins et al [50] reported that body weight decreased while acyl ghrelin and appetite increased after 12-week exercise (75% of HR, 3days/week) program in 22 sedentary and obese women.…”

Section: Ghrelin Response To Chronic Exercise and Appetite And Food Imentioning

confidence: 99%

Obesity, food intake and exercise: Relationship with ghrelin

Tiryaki-Sönmez

Vatansever

Ölçücü

et al. 2015

Biomedical Human Kinetics

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SummaryObesity, a disorder of body composition, is defined by a relative or absolute excess of body fat. In general adult population, obesity has been associated with a diverse array of adverse health outcomes, including major causes of death such as cancer, diabetes, cardiovascular disease, as well as functional impairment from problems such as osteoarthritis and sleep apnea. Ghrelin is a newly discovered peptide hormone which plays an important role in obesity. It is a powerful, endogenous orexigenic peptide and has a crucial function in appetite regulation, as well as short -and long-term energy homeostasis. In the presence of increased obesity, decreased physical activity, and high food consumption, the relationship between exercise, appetite, food intake and ghrelin levels has important implications. In this review, we discuss the effect of acute and chronic exercise performance on appetite, food intake and ghrelin and their relationships.

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Effects of resistance exercise training on acyl-ghrelin and obestatin levels in hemodialysis patients

Cited by 17 publications

References 28 publications

The effect of intradialytic exercise twice a week on the physical capacity, inflammation, and nutritional status of dialysis patients: A randomized controlled trial

The effect of intradialytic exercise twice a week on the physical capacity, inflammation, and nutritional status of dialysis patients: A randomized controlled trial

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

Obesity, food intake and exercise: Relationship with ghrelin

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