Effects of resveratrol on female reproduction: A review

Sirotkin, Alexander V.

doi:10.1002/ptr.7185

Cited by 7 publications

(4 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, resveratrol levels may be translated, via SIRT1, into the development of inflammation, regulation of apoptosis, mitochondrial function, and protection from oxidative stress. Among other reasons, sirtuin has become a therapeutic target in reproductive system diseases [ 28 ]. Mitochondrial activity, as well as the efficiency of the organization of cell organelles, is one of the keys to achieving good-quality oocytes.…”

Section: Interaction Between Sirt1 and Resveratrolmentioning

confidence: 99%

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Grzeczka

Kordowitzki

2022

Nutrients

View full text Add to dashboard Cite

It is well-known that there is an enormous variability in the aging-related decline of oocytes’ quantity and their developmental competence among mammalian species. The implication of female germline aging is profound from the perspective of evolutionary conservation of the aging mechanism, a topic of continuous and widespread interest that has yet to be fully addressed for the mammalian oocyte. There is a certain need to develop novel antiaging strategies to delay or slow down aging, or even to reverse the aging phenotype in the oocyte. In the past two decades, several antioxidants have been tested for this purpose. Resveratrol is one of these latter-mentioned compounds, which has shown anti-inflammatory and antiaging properties in a dose-dependent manner. Interestingly, resveratrol appears to enhance the activity of so-called Sirtuin 1, too. Therefore, the aim of this review is to summarize and discuss the latest findings related to resveratrol, Sirtuin 1, and their crosstalk and influence on the mammalian oocyte to elucidate the question of whether these factors can delay or slow down reproductive aging.

show abstract

Section: Interaction Between Sirt1 and Resveratrolmentioning

confidence: 99%

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Grzeczka

Kordowitzki

2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…Resveratrol has stilbenoid chemistry which is produced by more than 70 species of plants in response to stress, injury, infection, or ultraviolet radiations ( Sirotkin, 2021 ). Resveratrol was found to have an apoptotic induction in uterine cancer cells.…”

Section: Natural Kinase Inhibitors For Management Of Endometrial/uter...mentioning

confidence: 99%

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

et al. 2022

View full text Add to dashboard Cite

Endometrial cancer (EC) is the sixth most prevalent type of cancer among women. Kinases, enzymes mediating the transfer of adenosine triphosphate (ATP) in several signaling pathways, play a significant role in carcinogenesis and cancer cells’ survival and proliferation. Cyclin-dependent kinases (CDKs) are involved in EC pathogenesis; therefore, CDK inhibitors (CDKin) have a noteworthy therapeutic potential in this type of cancer, particularly in EC type 1. Natural compounds have been used for decades in the treatment of cancer serving as a source of anticancer bioactive molecules. Many phenolic and non-phenolic natural compounds covering flavonoids, stilbenoids, coumarins, biphenyl compounds, alkaloids, glycosides, terpenes, and terpenoids have shown moderate to high effectiveness against CDKin-mediated carcinogenic signaling pathways (PI3K, ERK1/2, Akt, ATM, mTOR, TP53). Pharmaceutical regimens based on two natural compounds, trabectedin and ixabepilone, have been investigated in humans showing short and midterm efficacy as second-line treatments in phase II clinical trials. The purpose of this review is twofold: the authors first provide an overview of the involvement of kinases and kinase inhibitors in the pathogenesis and treatment of EC and then discuss the existing evidence about natural products’ derived kinase inhibitors in the management of the disease and outline relevant future research.

show abstract

“…In females, resveratrol is considered a natural phytoestrogen since its chemical structure is similar to that of some estrogens, such as diethylstilbestrol. Although some publications have shown a negative influence of resveratrol on female reproductive processes [23], several studies have demonstrated beneficial effects of resveratrol. It has been shown to promote ovarian cell culture, in vitro fertilization of oocytes, ovarian stimulation, ovarian follicular growth and oocyte maturation, embryonic development, cryopreservation of oocytes and embryos, and it can improve the quality of oocytes obtained from aged females [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction

Guillot

Lemay

Allouche

et al. 2023

IJMS

View full text Add to dashboard Cite

Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis of CVDs; and endothelial colony-forming cells (ECFCs) have been identified as key factors in endothelial repair. In a rat model of IUGR induced by a maternal low-protein diet, we observed an altered functionality of ECFCs in 6-month-old males, which was associated with arterial hypertension related to oxidative stress and stress-induced premature senescence (SIPS). Resveratrol (R), a polyphenol compound, was found to improve cardiovascular function. In this study, we investigated whether resveratrol could reverse ECFC dysfunctions in the IUGR group. ECFCs were isolated from IUGR and control (CTRL) males and were treated with R (1 μM) or dimethylsulfoxide (DMSO) for 48 h. In the IUGR-ECFCs, R increased proliferation (5′-bromo-2′-deoxyuridine (BrdU) incorporation, p < 0.001) and improved capillary-like outgrowth sprout formation (in Matrigel), nitric oxide (NO) production (fluorescent dye, p < 0.01), and endothelial nitric oxide synthase (eNOS) expression (immunofluorescence, p < 0.001). In addition, R decreased oxidative stress with reduced superoxide anion production (fluorescent dye, p < 0.001); increased Cu/Zn superoxide dismutase expression (Western blot, p < 0.05); and reversed SIPS with decreased beta-galactosidase activity (p < 0.001), and decreased p16ink4a (p < 0.05) and increased Sirtuin-1 (p < 0.05) expressions (Western blot). No effects of R were observed in the CTRL-ECFCs. These results suggest that R reverses long-term ECFC dysfunctions related to IUGR.

show abstract

Effects of resveratrol on female reproduction: A review

Cited by 7 publications

References 89 publications

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?

Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies

Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction

Contact Info

Product

Resources

About