Effects of Sandimmune Neoral on Collagen-Induced Arthritis in DA Rats: Characterization by High Resolution Three-Dimensional Magnetic Resonance Imaging and by Histology

A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat

“…These included the measurement of paw volume (edema), made possible by the development of semiautomated mercury plethysmography (12), changes in paw temperature and grip responses (13), levels of acute-phase reactants (14,15), histopathologic changes (16,17), protein and messenger RNA levels of cytokines and other inflammatory mediators in the joint (18), expression of cell adhesion molecules (19), and the presence of specific biochemical markers of bone resorption/formation in urine (19) and serum (20). Pharmacologic approaches have also been widely used to determine the relative importance of immunologic events in this model and the therapeutic potential suggested by their regulation (12,(21)(22)(23)(24)(25)(26)(27).…”

Suppression of Collagen-Induced Arthritis in Rats by Continuous Administration of Dae-Bang-Poong-Tang (Da-Fang-Feng-Tang)

“…But analysis of the morphological changes also constitutes an important aspect of arthritis characterization. Rheumatoid arthritis pathology reveals inflammation in the articular tissue, cartilage destruction with formation of extensive pannus formation and bone erosion (Beckmann et aL, 1998). In this study, these histological symptoms and severity of the collagen-induced arthritis in rats were reduced by administering Dae-Bang-Poong-Tang and mild infiltration of inflammatory cells were merely observed in the articular capsule.…”

“…was mainly observed in the zone of hyaline cartilage and a weaker binding pattern was shown in the calcified cartilage; 2) were mainly observed in the zone of hyaline cartilage; ' was mainly observed in the zone of calcified cartilage; Degrees of affinity are listed in Table 3. In the experimental rats, iNOS expression was decreased in all regions compared with the controls.…”

“…It was concluded that Dae-Bang-Poong-Tang showed a notable protection against histological changes and histochemical staining, and it acted as an inhibitor of iNOS expression. Dae-Bang-Poong-Tang may be used as a complementary therapeutic agent to alleviate the rheumatoid arthritis.Xvheumatoid arthritis, a chronic systemic disease of unknown etiology, develops an inflammatory synovitis with neovascularization and pannus formation and ultimately leads to erosive joint destruction and deformities (Stuart et al, 1982;Beckmann et al, 1998). The collagen-induced arthritis is an immunologically complex model involving both cellular and humoral mechanism and has been used for many years for evaluation of antirheumatoid arthritis agents (Oliver et al, 1995;Horsfall et al, 1997).…”

Effects of Electroacupuncture with Different Frequencies on the Glycoconjugate Alterations in Articular Cartilage in the Ankle Joints of Complete Freund's Adjuvant-injected Rats

“…However, EA stimulation with all frequencies, especially 2 Hz EA stimulation, produced a significant anti-edema effect as compared to CFA-injected control rats. Adjuvant arthritis develops as an inflammatory synovitis and ultimately leads to erosion of articular cartilage leading to joint destruction (Beckmann et al, 1998). Articular cartilage, a specialized connective tissue, consists of a relatively small number of chondrocytes distributed throughout an extracellular matrix composed of collagen fibrils,…”