Effects of sauna bathing on stress-related genes expression in athletes and non-athletes

Żychowska, Małgorzata; Półrola, Paweł; Chruściński, Grzegorz; Zielińska, Jolanta; Góral-Półrola, Jolanta

doi:10.5604/12321966.1233977

Cited by 13 publications

(15 citation statements)

References 23 publications

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“…In the men from the T group, a significant level of TOS was demonstrated after a series of sauna treatments. This observation confirms the adaptive role of physical training [22,23]. No statistically significant differences were observed between the study groups, as far as the concentration of 3-nitrotyrosine in plasma is concerned, before starting thermal treatments in the sauna.…”

Section: Discussionsupporting

confidence: 75%

“…mentioning that, after the series of sauna treatments, significantly lower HR values were observed before the last bath in the males from the T group as compared to the NT group. This can suggest a common adaptive effect of long-term athletic training and a better acclimation in high temperatures of the sauna [21][22][23]. The adaptation can also be indicated by the fact that the change in HR values (Δ1 and Δ2) was significantly lower during the last treatment, in comparison to the first one.…”

Section: Discussionmentioning

confidence: 90%

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The influence of Finnish sauna treatments on the concentrations of nitric oxide, 3-nitrotyrosine and selected markers of oxidative status in training and non-training men

Gryka

Pilch

Czerwińska-Ledwig

et al. 2020

Int J Occup Med Environ Health

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The aim of the study was to evaluate the effects of repeated Finnish sauna baths on the concentrations of nitric oxide metabolites (NOx) and 3-nitrotyrosine in relation to pro-oxidative and antioxidative status in young males with different physical activity levels. Material and Methods: The study was performed on healthy males (aged 20-25 years), representing the training (T, N = 10) and non-training groups (NT, N = 10). The protocol included a series of 10 sauna baths during 3 weeks. One bath consisted of three 15-min sessions, with 2 min recovery. Before the first and the 10th treatment, measurements of body composition, blood pressure, rectal temperature, and plasma concentrations of the total pro-oxidative and antioxidative status, 3-nitrotyrosine and NOx were performed. Results: A significant increase in physiological parameters during sauna treatments, as well as a significant decrease in the total antioxidative status before the 10th bath, were observed in both groups. The series of sauna baths caused a significant increase in the total antioxidative status in the T group, and a decrease in the total oxidative status in the NT group. A significant decrease in 3-nitrotyrosine in both groups before the last treatment, and also in the T group after the last treatment, was noted. In both groups, a significant increase in NOx concentrations was observed after the first bath. Conclusions: A series of sauna baths contributes to the improvement in the prooxidative/antioxidative balance. The increased production of nitric oxide may lead to a better vascular relaxation and blood flow.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 90%

The influence of Finnish sauna treatments on the concentrations of nitric oxide, 3-nitrotyrosine and selected markers of oxidative status in training and non-training men

Gryka

Pilch

Czerwińska-Ledwig

et al. 2020

Int J Occup Med Environ Health

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“…Additionally, hyperthermia also induced an increase in cytokine levels in these cell culture models 55 , 57 , 58 . Studies in humans have shown that IL-6 seems to be increased by heat exposure only in a dose-dependent manner 8 , 59 , 60 . However, the source of IL-6 after heat exposure is still unknown 59 .…”

Section: Discussionmentioning

confidence: 99%

“…However, exercise studies only include well-trained athletes as the intensity needed to induce increased permeability is rather high (e.g., 60 min running at 80% of V0 2 max) and is difficult to achieve for untrained individuals 3 , 6 . Moreover, it is known that untrained and trained individuals differ when it comes to body composition, functional capacity 7 and thermotolerance 8 . Hence, the results observed in trained subjects cannot necessarily be extrapolated to the rest of the population.…”

Section: Introductionmentioning

confidence: 99%

Sauna dehydration as a new physiological challenge model for intestinal barrier function

Rubio

Eriksson

Brummer

et al. 2021

Sci Rep

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The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to assess their efficiency. This study investigated the effect of sauna-induced dehydration on intestinal barrier function (clinicaltrials.gov: NCT03620825). Twenty healthy subjects underwent three conditions in random order: (1) Sauna dehydration (loss of 3% body weight), (2) non-steroidal anti-inflammatory drug (NSAID) intake, (3) negative control. Intestinal permeability was assessed by a multi-sugar urinary recovery test, while intestinal damage, bacterial translocation and cytokines were assessed by plasma markers. The sauna dehydration protocol resulted in an increase in gastroduodenal and small intestinal permeability. Presumably, this increase occurred without substantial damage to the enterocytes as plasma intestinal fatty acid-binding protein (I-FABP) and liver fatty acid-binding protein (L-FABP) were not affected. In addition, we observed significant increases in levels of lipopolysaccharide-binding protein (LBP), IL-6 and IL-8, while sCD14, IL-10, IFN-ɣ and TNF-α were not affected. These results suggest that sauna dehydration increased intestinal permeability and could be applied as a new physiological in vivo challenge model for intestinal barrier function.

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“…However, a more modest thermal load (i.e. 1 h HWI in water set at 39 °C) does not result in an increased iHsp72 expression (Morton et al 2007; Hoekstra et al 2018), although iHsp72 mRNA expression is elevated after 30 min of sauna bathing at 98.2 °C and 10% humidity (Zychowska et al 2017). While a temperature threshold may therefore exist for iHsp72, the effect of heat on iIL-6 is less clear.…”

Section: Introductionmentioning

confidence: 99%

The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes

Hoekstra

Wright

Bishop

et al. 2019

Cell Stress and Chaperones

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The acute inflammatory response to active or passive activities that increase body temperature may aid to reduce chronic low-grade inflammation. This study investigates the impact of temperature and extracellular heat shock protein 72 (eHsp72) on the acute intracellular Hsp72 (iHsp72) and interleukin-6 (iIL-6) response in monocytes. Whole blood was incubated for 2 h at 37.0 °C, 38.5 °C and 40.0 °C, in the absence or presence of 0.5 μg/ml eHsp72. Flow cytometry was used to assess iHsp72 and iIL-6 expression in total monocytes and the three monocyte subsets. Incubation at 40.0 °C ( p < 0.001) but not 38.5 °C ( p = 0.085) increased iHsp72 expression when compared with 37.0 °C, while there was no effect of temperature on iIL-6 expression ( p = 0.635). Following incubation with eHsp72, the expression of iHsp72 in classical monocytes was reduced at all temperatures ( p < 0.001), while there was no effect of eHsp72 on iIL-6 expression ( p = 0.071). Large temperature elevations are needed to induce an acute iHsp72 response in monocytes. In addition, contrary to its suggested role as a danger signal for the innate immune system, eHsp72 reduced iHsp72 and iIL-6 expression in monocytes. Electronic supplementary material The online version of this article (10.1007/s12192-019-00972-6) contains supplementary material, which is available to authorized users.

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Effects of sauna bathing on stress-related genes expression in athletes and non-athletes

Cited by 13 publications

References 23 publications

The influence of Finnish sauna treatments on the concentrations of nitric oxide, 3-nitrotyrosine and selected markers of oxidative status in training and non-training men

The influence of Finnish sauna treatments on the concentrations of nitric oxide, 3-nitrotyrosine and selected markers of oxidative status in training and non-training men

Sauna dehydration as a new physiological challenge model for intestinal barrier function

The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes

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