Effects of Schisandra chinensis extract on gastrointestinal motility in mice

Ahn, Tae-Seok; Kim, Dae Geon; Hong, Noo Ri; Park, Hyun Soo; Kim, Hyungwoo; Ha, Ki Tae; Jeon, Ju Hong; So, Insuk; Kim, Byung Joo

doi:10.1016/j.jep.2015.03.071

Cited by 18 publications

(11 citation statements)

References 40 publications

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“…39 Therefore, this action of pacemaker potential depolarization may produce intensication of the intestinal motility rate. For this point, many recent research showed that diverse traditional herbal medicines such as Schisandra chinensis, 40 Ge-Gen-Tang, 41 Liriope platyphylla 42 and Citrus unshiu 43 demonstrated elicit excitatory/ inhibitory effects on the ICC pacemaker activity, which supports the notion that ICCs are critical in the control of smooth muscle motility in the GI tract.…”

Section: Tv-ae Consumption Accelerates Git In Healthy and Constipatedmentioning

confidence: 76%

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

et al. 2019

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Section: Tv-ae Consumption Accelerates Git In Healthy and Constipatedmentioning

confidence: 76%

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

et al. 2019

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“…Baill. extract (SC extract) was determined to modulate ICC pacemaker potentials via external and internal Ca 2+ regulation, and via G protein and the phospholipase C (PLC) pathway, in a dose-dependent manner, and increased intestinal transit rates in mouse models of normal and abnormal GI motility (43). These studies indicate that traditional medicines, such as PF, ginseng, SHXXT and SC may potentially be used as gastroprokinetic agents.…”

Section: Discussionmentioning

confidence: 99%

Effects of Prunus mume Siebold & Zucc. in the pacemaking activity of interstitial cells of Cajal in murine small intestine

Lee

Kim

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Interstitial cells of Cajal (ICCs) function as pacemaker cells in the gastrointestinal (GI) tract and therefore, serve an important role in regulating GI motility. The effects of a species of plum (Prunus mume Siebold & Zucc.) on cultured ICC cluster-induced pacemaker potentials in the mouse small intestine were investigated, and the effects of a methanolic extract of Prunus mume (m-PM) on ICC pacemaker activities were examined using the whole-cell patch-clamp technique. ICC pacemaker membrane potentials were depolarized by m-PM in a concentration dependent manner in current clamp mode. 4-Diphenylacetoxy-N-methyl-piperidine methiodide, which is a muscarinic 3 (M 3 ) receptor antagonist, was able to block m-PM-induced pacemaker potential increases, whereas methoctramine, which is a muscarinic 2 (M 2 ) receptor antagonist, was not. When 1 mM guanosine diphosphate β-5 was present in the pipette solution, m-PM induced slight pacemaker depolarization. Following pretreatment in bath solution of Ca 2+ -free solution or a Ca 2+ -ATPase inhibitor in endoplasmic reticulum, the pacemaker currents were inhibited. Furthermore, pretreatment with PD98059, SB203580 or SP600125, which is a c-jun NH2-terminal kinase inhibitor, blocked m-PM-induced ICC potential depolarization. Furthermore, m-PM inhibited transient receptor potential melastatin (TRPM) 7 channels, but did not affect Ca 2+ -activated Cl -channels. These results suggest that m-PM is able to modulate pacemaker potentials through the muscarinic M 3 receptor, via G-protein and external and internal Ca 2+ , in a mitogen-activated protein kinase and TRPM7-dependent manner. Therefore, m-PM may provide a basis for the development of a novel gastroprokinetic agent. IntroductionThe fruit of the plum tree Prunus mume Siebold & Zucc. (PM) is used across East Asia, particularly in Korea and Japan (1), as a traditional herbal medicine for the relief of digestive problems, fatigue and fever. PM contains a number of phenolic compounds, including phenolic acids and flavonoids (1,2), which have antioxidant and free radical scavenging activities in vivo (3-6). Furthermore, PM extracts exhibit many pharmacological activities, including antimicrobial (7-10), immune enhancing (11), anti-cancer (1,12,13), and anti-fatigue (14) effects, and have been demonstrated to enhance osteoclast differentiation (15) and improve blood flow (16). Additionally, previous studies have reported that using PM extracts with probiotics inhibits the development of atopic dermatitis (17) and enhances immunity (18).Interstitial cells of Cajal (ICCs) are the pacemakers of the gastro-intestinal tract and generate rhythmic responses in cell membrane electrical potentials (19,20), thus serving important roles in the regulation of GI motility (21). Additionally, endogenous agents are able to regulate GI motility function via ICCs (22-25). Furthermore, transient receptor potential melastatin (TRPM) 7 (26) or Cl -channels, such as anoctamin1 (ANO1) (27)(28)(29), are associated with pacemaker potentials in the...

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“…administration of the Lizhong Tang extract (or DW as vehicle) by intraperitoneally (i.p.) injecting 10 mL/kg AA (0.6%, w/v, in saline) as previously described[12-14]. After injecting AA, the mice were placed in individual cages and allowed to recover for 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…As previously described by Scarpignato et al[16], the mice were fasted for 24 h with free access to water[14]. Gastric emptying (GE) was performed by administering a 0.05% (w/v) phenol red solution (0.5 mL/mouse) 30 min after treatment with the Lizhong Tang extract.…”

Section: Methodsmentioning

confidence: 99%

Effects of Lizhong Tang on gastrointestinal motility in mice

Lee

Park

et al. 2016

WJG

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AIMTo investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice.METHODSThe in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).RESULTSIn normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54.4% ± 1.9% vs 65.2% ± 1.8%, P < 0.01 with 0.1 g/kg Lizhong Tang and 54.4% ± 1.9% vs 83.8% ± 1.9%, P < 0.01 with 1 g/kg Lizhong Tang; GE values: 60.7% ± 1.9% vs 66.8% ± 2.1%, P < 0.05 with 0.1 g/kg Lizhong Tang and 60.7% ± 1.9% vs 72.5% ± 1.7%, P < 0.01 with 1 g/kg Lizhong Tang). The ITRs of the GMD mice were significantly reduced compared with those of the normal mice, which were significantly and dose-dependently reversed by Lizhong Tang. Additionally, in loperamide- and cisplatin-induced models of GE delay, Lizhong Tang administration reversed the GE deficits.CONCLUSIONThese results suggest that Lizhong Tang may be a novel candidate for development as a prokinetic treatment for the GI tract.

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Effects of Schisandra chinensis extract on gastrointestinal motility in mice

Cited by 18 publications

References 40 publications

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

Effects of Prunus mume Siebold & Zucc. in the pacemaking activity of interstitial cells of Cajal in murine small intestine

Effects of Lizhong Tang on gastrointestinal motility in mice

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