Effects of seaweed supplementation on blood glucose concentration, lipid profile, and antioxidant enzyme activities in patients with type 2 diabetes mellitus

Abstract

The present study was carried out to evaluate the physiological effects of seaweed supplementation on blood glucose levels, lipid profile, and antioxidant enzyme activities in subjects with type 2 diabetes mellitus. Subjects were randomized into either a control group or a seaweed supplementation group. Pills with equal parts of dry powdered sea tangle and sea mustard were provided to the seaweed supplementation group three times a day for 4 weeks. Total daily consumption of seaweed was 48 g. We found that total dietary fiber intake was 2.5 times higher in subjects receiving seaweed supplementation than in the control group. Accordingly, fasting blood glucose levels (p<0.01) and 2-hour postprandial blood glucose measurements (p<0.05) were decreased significantly in those ingesting seaweed. Furthermore, the serum concentrations of triglycerides were decreased and high-density lipoprotein cholesterol was increased significantly in seaweed supplement group (p<0.05). However, the concentrations of total cholesterol and low-density lipoprotein cholesterol were not affected by seaweed supplementation. The level of thiobarbituric acid reactive substances in erythrocytes was significantly lower with seaweed supplementation compared to controls (p<0.05). Catalase and glutathione peroxidase activities with seaweed supplementation were higher than the controls (p<0.05), but superoxide dismutase activity was not affected. We, therefore, conclude that ingestion of seaweed influences glycemic control, lowers blood lipids, and increases antioxidant enzyme activities.

Effects of Haematococcus pluvialis supplementation on antioxidant system and metabolism in rainbow trout (Oncorhynchus mykiss)

“…ALP Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate aminotransferase treatment groups was better than that in control fish on days 1 and 4 even though slight increase in antioxidant activity was noted in the group received the highest dose of the alga (10 g kg -1 ) on day 1. Such increase in antioxidative activity was shown in different animals fed on other dietary products containing astaxanthin (Nakano et al 1999;Pan et al 2003;Kim et al 2008). Kamath et al (2008) also showed that astaxanthin derived from H.p protects gastric mucosal injury by antioxidative mechanism in rats.…”

The Effectiveness of a Bioactive Food Compound in the Lipid Control of Individuals with HIV/AIDS

“…However, Kim et al [43] reported that the diet of diabetic mice foods high in fiber and polyunsaturated fatty acids resulted in decreased levels of triglycerides, total cholesterol and LDL-C, although it was not effective in improving glycemic control. However, Raimondi et al [44] showed that nutritional counseling has a beneficial effect on the lipid profile and anthropometric parameters and the daily consumption of 40 g of oat bran provided an additional benefit in reducing insulin resistance parameters.…”

Seaweeds in Human Health

“…They documented that a 2.5-fold increase of seaweed consumption significantly lowered serum triglyceride and increased HDL cholesterol levels with no differences in LDL or total cholesterol levels (Kim et al, 2008). They documented that a 2.5-fold increase of seaweed consumption significantly lowered serum triglyceride and increased HDL cholesterol levels with no differences in LDL or total cholesterol levels (Kim et al, 2008).…”