Effects of simvastatin on bone regeneration in the mandibles of ovariectomized rats and on blood cholesterol levels.

Abstract

Abstract:The purpose of this study was to evaluate the effects of simvastatin on guided bone regeneration in the mandibles of ovariectomized rats, and to observe their blood cholesterol levels. Seventy female rats were divided into two groups: control and treated, both groups containing normal and ovariectomized rats. A month after ovariectomy a bone defect was created in the mandible, and was covered by a polytetrafluoroethylene membrane. The treated groups received simvastatin orally for 15 or 30 days. The rats were sacrificed 15, 30 or 60 days after surgery, at which time a blood sample was extracted for blood cholesterol level analysis and the mandible was extracted for densitometric, histological and morphometric analysis. All specimens underwent analysis of variance. The ovariectomized animals had higher cholesterol levels than the treated normal animals, and no significant difference was found between the different treatment periods and the sacrifice times. The densitometric, histological and morphometric analysis showed that the treated ovariectomized animals developed more new bone than the control ovariectomized rats, but no significant difference was observed between the treatment periods. It can be concluded that the deficiency of estrogen increased the level of blood cholesterol and that the simvastatin aided new bone formation in the ovariectomized animals. (J. Oral Sci. 44, 117-124, 2002)

Osteogenic/Odontogenic Bioengineering with co-Administration of Simvastatin and Hydroxyapatite on Poly Caprolactone Based Nanofibrous Scaffold

“…7,8 Although some studies have not confirmed the effect of statins on the initiation and formation of bone. 9,10 Von stechow et al evaluated the effect of statins on elimination of bony defects in the mandible of rabbits and reported that the amounts of regenerated bone were not significantly different with and without exposure to statins. 10 Therefore, further studies are necessary to determine the role of this material in the induction of bone regeneration.…”

Osteogenic Effect of Local Administration of Fluvastatin using a Fluvastatin-gelatin Complex in Senile Osteoporosis Model Rat

“…Many studies of bone formation in vivo using statins reported the effect of systemic administration [7][8][9][10][11][12][13] . Some authors reported the osteogenic effects of the systemic administration of statins on osteoporosis using ovariectomized rats [14][15][16][17] .…”

Combination of simvastatin and hydroxyapatite fiber induces bone augmentation

“…In recent years, several studies have shown that statins enhance BMP-2 and vascular endothelial growth factor (VEGF) gene expression in osteoblasts, suggesting their bone-promoting effect [21,24,25]. Animal studies involving systemic or local administration of statins have also yielded positive results [23,[26][27][28]. However, systemic administration of statins for bone formation requires a much more higher dose than for lowering cholesterol, and safety has not yet been clearly reported [29,30].…”